Neurology and Neurosurgery

Below are current clinical trials.

129 studies in Neurology and Neurosurgery
(open studies only).

Filter this list of studies by location, status and more.

1. Electrophysiological Biomarkers for Parkinson's Disease

   Scottsdale/Phoenix, Ariz.

   This study will determine the validity of predictive and surrogate biomarkers for the detection of Parkinson's disease and Parkinson's disease cognitive decline.

2. A Registry to Follow Long-Term Outcomes for Mother and Child Pairs After Fetal Surgery for Spina Bifida

   Rochester, Minn.

   The purpose of this study is to form a registry of data on the long term physical and mental health outcomes of the mother and child following fetal surgical repair for spina bifida.

3. Treatment Resistant Depression Subcallosal Cingulate Network

   Rochester, Minn.

   The purpose of this study is to evaluate the effectiveness and safety of bilateral stimulation of the SCCwm using the Infinity DBS system as an adjunctive treatment of non-psychotic unipolar Major Depression Disorder (MDD) for adults who are experiencing an Major Depressive Episode (MDE) with inadequate response to 4 or more antidepressant treatments.

4. A Registry Called Every Child for Collecting Data and Biology Specimens on Younger Patients with Cancer

   Rochester, Minn.

   The purpose of this registry called Every Child, is to collect data and biospecimens from multiple body sources for younger patients with cancer over time. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care.

5. Dynamic Evaluation Of Spinal Alignment And Balance In Adults With Spinal Deformity Using Momentum Spine

   Rochester, Minn.

   The purpose of this study is to determine whether the Momentum Spine™ application, with its newly developed dynamic spinal metrics, can accurately and feasibly assess postural parameters in adults with spinal deformity across the continuum of care: conservative management, before and after spinal surgery.

6. A Study of Early-onset Alzheimer's Disease

   Rochester, Minn., Jacksonville, Fla.

   The purpose of this Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is designed to look at disease progression in individuals with early onset cognitive impairment . Clinical/cognitive, imaging, biomarker, and genetic characteristics will be assessed across three cohorts: (1) early onset Alzheimer's Disease (EOAD) participants, (2) early onset non-Alzheimer's Disease (EO-nonAD) participants,and (3) cognitively normal (CN) control participants.

7. A Study of the Brain & Body Donation Program

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to study the structure and biochemistry of the brain and/or bodily fluid and tissue after death.  Comparison of specimens from normal and diseased individuals provide essential clues that lead to a greater understanding of the diseased state which, in turn, will lead to new ideas for therapy.

8. Inherited Muscle Diseases Repository

   Rochester, Minn.

   To establish a repository of DNA samples collected prospectively from patients with inherited myopathies of unknown molecular and/or biochemical defect. To access residual muscle specimens from diagnostic muscle biopsies obtained as part of the routine medical care. The biospecimens will be used to better understanding the underlying molecular defects and mechanisms of muscle diseases.

9. Gemini Study to Evaluate the Integration of Cancer Genetic Testing into a Cancer Clinical Practice at Mayo Clinic at Arizona

   Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

   The purpose of this study is to determine the prevalence of genetic mutations in cancer patients from various ethnic populations seeking care at Mayo Clinic cancer clinics.

10. A Study to Evaluate Electrophysiology of Deep Brain Stimulation

    Rochester, Minn.

    The primary purpose of this study is to map the electrophysiological properties of deep brain stimulation (DBS) targets and associated areas by analyzing signals recorded for clinical purposes.  Electrophysiological properties such as spike statistics, power spectral density, spike-field coupling, and phase-amplitude coupling may be correlated to anatomic structures.  An atlas with these properties could improve DBS lead targeting.