Neurology and Neurosurgery

Below are current clinical trials.

121 studies in Neurology and Neurosurgery
(open studies only).

Filter this list of studies by location, status and more.

1. Study Of Neurophysiologically Based Brain State Tracking And Modulation In Focal Epilepsy

   Rochester, Minn.

   The purpose of this study is to track seizure occurrence, seizure probability, behavioral state, cognition, and mood using an implantable brain sensing and stimulation device (Medtronic RC+S Summit) coupled to an external, handheld, patient assistant device (PAD) with capability for patient interaction (patient data input). The system (RC+S & PAD) provides intracranial EEG (iEEG) sensing, electrical brain stimulation, and machine learning algorithms running on the RC+S and PAD that will be coupled with electrical brain stimulation (EBS) to prevent seizures and improve quality of life in patients with epilepsy

2. Optimizing Rehabilitation Effect With Electrical Stimulation Therapy Rehab

   Rochester, Minn., Jacksonville, Fla.

   The purpose of this study is to evaluate the safety and effectiveness of deep brain stimulation (DBS) of the dentate nucleus area for improving functional status in patients with moderate to severe residual upper-extremity motor impairment due to stroke.

    

    

3. A Long Term Study Of Molecular And Structural Imaging In Atypical Alzheimer's Disease

   Rochester, Minn.

   The purpose of this study is to learn more about amyloid and tau burden in the brain of patients with Atypical Alzheimer's Disease and how that burden may change over a two-year period.

4. A Study Of Molecular Anatomic Imaging Analysis Of Tau, The Primary Pathological Protein In Progressive Supranuclear Palsy

   Rochester, Minn.

   The purpose of this study is to learn more about the distribution of the pathological protein tau in the living brains of patients with Progressive Supranuclear Palsy (PSP).

5. Diagnosing Craniosynostosis MR with Facial Recognition Software

   Rochester, Minn.

   The purpose of this study is to use photographs of infants, both normal and diagnosed with Craniosynostosis, to train a facial recognition algorithm to identify craniosynostosis before evaluation by a healthcare professional.

6. A Study to Evaluate Awake vs. Asleep Spine Surgery

   Jacksonville, Fla.

   Patients undergoing spine lumbar surgery will be asked to perform short exams/questionnaires aimed at determining cognitive function, quality of life, health outcomes twice post surgery with a baseline performance prior to surgery.

7. A Study to Establish a Parkinson’s Disease (PD) Cohort using the Parkinson’s Progression Markers Initiative (PPMI)

   Scottsdale/Phoenix, Ariz.

   The Parkinson Progression Marker Initiative (PPMI) is a study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of Parkinson’s disease (PD) progression in study participants with manifest PD, prodromal PD, and healthy controls. The overall goal of PPMI is to identify markers of disease progression for use in clinical trials of therapies to reduce progression of PD disability.

8. PLS Natural History Study

   Rochester, Minn., Jacksonville, Fla.

   The purpose of this study is to develop a natural history dataset and biorepository of early Primary Lateral Sclerosis (PLS) and well-established PLS cases for future clinical trials.

9. A Study to Evaluate Droperidol Use in the Emergency Department and the Effect on QTc

   Rochester, Minn.

   The purpose of this study is to study the length of the QTc interval in patients receiving the standard of care dose of intravenous droperidol for headache or migraine, nausea, pain, and indications other than agitation over 30 minutes.

10. Cognitive Advancement and Recovery in VNS-Rehabilitation (CARE)

    Rochester, Minn.

    The purpose of this study is to investigate whether VNS therapy leads to any changes in the cognitive functions of individuals who have survived a stroke.