Grand Rounds: Individualizing Diagnosis and Therapy for IBS April 11, 2014 Overview Show transcript Overview Arthur Beyder, M.D., Ph.D., and Gianrico Farrugia, M.D., discuss the morbidity, pathophysiology and genetics of irritable bowel syndrome (IBS), a complex genetic disease. In some cases, IBS is an ion channelopathy. Drs. Beyder and Farrugia discuss the involvement of SCN5A and NaV1.5 mutations in patients with IBS. Share Doximity Facebook LinkedIn Twitter Print details Receive Mayo Clinic news in your inbox. Sign up Related ContentArticleUnderstanding the needs and burdens of patients with CIC and IBS-CArticleAn updated appraisal of the SIBO hypothesis and the limits of breath testingVideoMotility Interest Group and Motility Clinic VID-20433422 Medical Professionals Grand Rounds: Individualizing Diagnosis and Therapy for IBS