Cholesterol-lowering supplements may be helpful

    Diet and exercise are proven ways to reduce cholesterol. Cholesterol-lowering supplements may help, too.

    If you've started to exercise and eat healthier foods to lower your cholesterol, you might wonder if a dietary supplement can help. Here are some cholesterol-lowering supplements to think about. Check with your healthcare professional before you try any.

    Cholesterol-lowering supplement What it might do Side effects and how it affects other medicines
    Berberine May lower low-density lipoprotein (LDL) cholesterol, the "bad" cholesterol, total cholesterol and triglycerides May cause loose stools trouble passing stool, gas, stomach upset or vomiting; may cause harm to babies during pregnancy and breastfeeding
    Fish oil May lower triglycerides, a type of fat in the blood that raises the risk of heart disease May cause a fishy aftertaste, bad breath, gas, upset stomach, vomiting or loose stools; may affect some blood-thinning medicines
    Flaxseed, ground May lower LDL cholesterol May cause gas, bloating or loose stool; may affect some blood-thinning medicines
    Garlic May slightly lower cholesterol, but studies have had mixed results May cause bad breath, body odor, upset stomach, vomiting and gas; may affect some blood-thinning medicines
    Green tea or green tea extract May lower LDL cholesterol and total cholesterol May cause upset stomach, vomiting, gas or loose stool; may affect blood-thinning medicines
    Niacin May lower LDL cholesterol and triglycerides; may improve high-density lipoprotein (HDL) cholesterol, the "good" cholesterol May cause itching and flushing, which are more common at the higher doses most often needed to affect cholesterol
    Plant stanols and sterols May lower LDL cholesterol, total cholesterol and triglycerides May cause loose stool

    Red yeast rice — Natural doesn't mean safe

    Some red yeast rice products have a substance called monacolin K. Monacolin K is like the active ingredient in lovastatin, a prescription medicine that lowers cholesterol. The amount of monacolin K in different brands of red rice yeast varies widely.

    Products that have monacolin K can cause the same types of side effects as lovastatin. These may include damage to the muscles, kidneys and liver. In the United States, the Food and Drug Administration has ruled that dietary supplements that have more than trace amounts of monacolin K are not approved and can't be sold legally as dietary supplements.

    Dietary supplements may not be enough

    Dietary supplements may help, but you also might need prescription medicines to get your cholesterol numbers to a safe level. Be sure to tell your healthcare professional if you take any dietary supplements. Some supplements can affect the medicines you take.

    1. Cholesterol management at a glance. National Center for Complementary and Integrative Health. https://www.nccih.nih.gov/health/cholesterol-management-at-a-glance. Accessed Aug. 18, 2025.
    2. Tangney CC, et al. Lipid management with diet or dietary supplements. https://www.uptodate.com/contents/search. Accessed Aug. 18, 2025.
    3. Ge Q, et al. Dietary supplements: Clinical cholesterol-lowering efficacy and potential mechanisms of action. International Journal of Food Sciences and Nutrition. 2024; doi:10.1080/09637486.2024.234230.
    4. High cholesterol and natural products: What the science says. National Center for Complementary and Integrative Health. https://www.nccih.nih.gov/health/providers/digest/high-cholesterol-and-natural-products-science. Accessed Aug. 18, 2025.
    5. Berberine. NatMed. https://naturalmedicines.therapeuticresearch.com. Accessed Aug. 19, 2025.
    6. Fish oil. NatMed. https://naturalmedicines.therapeuticresearch.com. Accessed Aug. 19, 2025.
    7. Flaxseed. NatMed. https://naturalmedicines.therapeuticresearch.com. Accessed Aug. 19, 2025.
    8. Green tea. NatMed. https://naturalmedicines.therapeuticresearch.com. Accessed Aug. 19, 2025.
    9. Niacin. NatMed. https://naturalmedicines.therapeuticresearch.com. Accessed Aug. 19, 2025.

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