Description and Brand Names

Drug information provided by: IBM Micromedex

US Brand Name

  1. Mvasi

Descriptions


Bevacizumab-awwb injection is given with other medicines to treat patients with metastatic (cancer that has spread) carcinoma of the colon or rectum.

Bevacizumab-awwb injection is also used together with other medicines (eg, carboplatin and paclitaxel) to treat nonsquamous, non-small cell lung cancer (NSCLC) that has spread, come back, or cannot be removed by surgery. It is also used to treat a type of brain tumor called glioblastoma that keeps coming back (recurrent).

Bevacizumab-awwb injection is also used in combination with other medicines (eg, interferon alfa) to treat patients with metastatic kidney cancer. It is also used in combination with other medicines (eg, paclitaxel and cisplatin, or paclitaxel and topotecan) to treat patients with cervical cancer that is continuing, keeps coming back, or has spread to other parts of the body.

Bevacizumab-awwb is an antineoplastic that helps the body fight cancer. It prevents the growth of certain types of blood vessels to cancer cells. This helps decrease the growth of cancer cells by starving them of the nutrients they need to grow.

This medicine is to be given only by or under the immediate supervision of your doctor.

This product is available in the following dosage forms:

  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of bevacizumab-awwb injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of bevacizumab-awwb injection in the elderly. However, elderly patients are more likely to have age-related heart or blood vessel problems, which may require caution in patients receiving bevacizumab-awwb injection.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Tofacitinib

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Angina (severe chest pain) or
  • Bleeding problems or
  • Blood clots or
  • Diabetes or
  • Esophagus problems or
  • Heart attack, history of or
  • Heart failure or
  • Hypertension (high blood pressure) or
  • Kidney problems or
  • Liver problems or
  • Protein in the urine or
  • Stomach or bowel problems (eg, blockage, fistula, perforation) or
  • Stroke, history of or
  • Wound healing problems—Use with caution. May make these conditions worse.
  • Hemoptysis (coughing up blood), recent—Should not be used in patients with this condition.

Proper Use

Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

A nurse or other trained health professional will give you this medicine in a medical facility. It is given through a needle placed into one of your veins. It must be given slowly, so the needle will need to stay in place for at least 30 to 90 minutes.

Precautions

It is very important that your doctor check your progress closely and at regular visits to make sure that this medicine is working properly. Blood and urine tests are needed to check for unwanted effects. Be sure to keep all appointments. You may be taught how to check your blood pressure at home.

Receiving this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to prevent pregnancy while you are receiving this medicine and for at least 6 months after the last dose. If you think you have become pregnant while receiving this medicine, tell your doctor right away.

Receiving this medicine may increase risk of ovarian failure. Talk with your doctor if you plan to have children. Some women receiving this medicine have become infertile (unable to have children).

This medicine can cause stomach or bowel perforation (tear or hole), including blockage. Check with your doctor right away if you have severe stomach pain, constipation, fever, nausea, or vomiting.

This medicine may also increase your risk of having a serious condition called tracheoesophageal fistula (an abnormal opening in one or more places between the esophagus and the trachea). Tell your doctor right away if you start having trouble swallowing, coughing, or choking while eating, trouble breathing, or chest pain or discomfort while you are receiving this medicine.

Make sure any doctor who treats you knows that you are receiving this medicine. You may need to stop receiving this medicine at least 4 weeks before and after having surgery.

This medicine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

  • If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
  • Check with your doctor immediately if you start to cough up blood or if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.
  • Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.
  • Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
  • Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.
  • Avoid contact sports or other situations where bruising or injury could occur.

This medicine may increase your risk of developing blood clots. Check with your doctor right away if you have swelling and pain in your arms, legs, or stomach, chest pain, shortness of breath, loss of sensation, confusion, or problems with muscle control or speech.

Your blood pressure might get too high while you are using this medicine. This may cause headaches, dizziness, or blurred vision. You might need to measure your blood pressure at home. If you think your blood pressure is too high, call your doctor right away.

This medicine may increase your chance of having a brain condition, called posterior reversible encephalopathy syndrome (PRES). Check with your doctor right away if you start having headaches, seizures, extreme drowsiness, confusion, or problems with vision while you are receiving this medicine.

This medicine may cause infusion-related reactions, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you start to have a fever, chills or shaking, dizziness, trouble breathing, itching or rash, lightheadedness or fainting after receiving this medicine.

Do not receive bevacizumab-awwb together with cancer medicines containing anthracycline, especially if you have heart failure.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Belching
  2. black, tarry stools
  3. bladder pain
  4. bleeding gums
  5. bloating or swelling of the face, arms, hands, lower legs, or feet
  6. blood in the urine or stools
  7. bloody nose
  8. bloody or cloudy urine
  9. blurred vision
  10. body aches or pain
  11. chest pain
  12. chills
  13. cloudy urine
  14. confusion
  15. cough
  16. diarrhea
  17. difficult or labored breathing
  18. difficult, burning, or painful urination
  19. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  20. dry mouth
  21. ear congestion
  22. fever
  23. flushed, dry skin
  24. frequent urge to urinate
  25. fruit-like breath odor
  26. headache
  27. heartburn
  28. hoarseness
  29. increased hunger
  30. increased thirst
  31. increased urination
  32. indigestion
  33. loss of voice
  34. lower back or side pain
  35. nausea
  36. nervousness
  37. pain, redness, or swelling in the arm or leg
  38. pelvic pain
  39. pinpoint red spots on the skin
  40. pounding in the ears
  41. rapid weight gain
  42. runny or stuffy nose
  43. slow or fast heartbeat
  44. slow wound healing
  45. sneezing
  46. sore throat
  47. sores on the skin
  48. sores, ulcers, or white spots on the lips or in the mouth
  49. stomach cramps, discomfort, upset, or pain
  50. swelling or inflammation of the mouth
  51. swollen glands
  52. tightness in the chest
  53. tingling of the hands or feet
  54. unexplained weight loss
  55. unusual bleeding or bruising
  56. unusual tiredness or weakness
  57. unusual weight gain or loss
  58. voice changes
  59. vomiting
  60. vomiting of blood or material that looks like coffee grounds
  61. watery or bloody diarrhea
  62. weight gain
  63. wrinkled skin
  64. yellow skin

Less common

  1. Bone pain
  2. difficulty with swallowing
  3. fainting
  4. severe constipation
  5. severe vomiting
  6. stomach pain or tenderness

Incidence not known

  1. Bloody mucus or unexplained nosebleeds
  2. constipation
  3. decreased vision or other changes in vision
  4. eye pain
  5. eye redness
  6. heavy jaw feeling
  7. high fever
  8. loosening of a tooth
  9. loss of vision
  10. pain, swelling, or numbness in the mouth or jaw
  11. pale skin
  12. severe stomach pain
  13. stomach cramping or burning
  14. stomach pain, usually after eating a meal
  15. sudden weakness in the arms or legs
  16. tearing of the eyes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Anxiety
  2. back pain
  3. bad, unusual, or unpleasant (after) taste
  4. change in walking and balance
  5. clumsiness or unsteadiness
  6. decreased weight
  7. difficulty in moving
  8. excess flow of tears
  9. joint pain or swelling
  10. lack or loss of strength
  11. loss of appetite
  12. loss or thinning of the hair
  13. pain in the rectum

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.