Survival rates By Mayo Clinic Staff Waldenstrom macroglobulinemia survival rates are given by risk group. Other cancers might give survival rates by stage, but stages don't apply to Waldenstrom macroglobulinemia. Instead, healthcare professionals use risk groups to describe the seriousness of the cancer. To decide on the risk group, the healthcare team uses the person's age and two blood tests, albumin and lactate dehydrogenase (LDH). People in the lower risk groups tend to live longer, while those in higher risk groups have a higher chance of dying of Waldenstrom macroglobulinemia. Survival rates show the percentage of people with this cancer who are still alive a certain number of years after diagnosis. For example, a five-year survival rate means the percentage of people living five years after diagnosis. The estimated five-year survival rates for each risk group: Low risk: about 93%. Low-intermediate risk: about 82%. Intermediate risk: about 69%. High risk: about 55%. Keep in mind that survival statistics take five years to collect. The most recent survival rates include people who had treatment for Waldenstrom macroglobulinemia more than five years ago. These people may not have had access to the latest treatments. Request an appointment Diagnosis & treatmentDoctors & departments Dec. 20, 2025 Share on: FacebookTwitter Living with waldenstrom macroglobulinemia? Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. Blood Cancers & Disorders Discussions My Bone Marrow Transplant (BMT/SCT) story: Will you share yours? 814 Replies Sat, Jan 10, 2026 chevron-right T cell large granulocytic leukemia 33 Replies Sat, Jan 10, 2026 chevron-right High Ferritin Levels: How can I lower my levels? 32 Replies Wed, Jan 07, 2026 chevron-right See more discussions Show references Waldenstrom macroglobulinemia/lymphoplasmacytic lymphoma. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1475. Accessed Nov. 3, 2025. Epidemiology, pathogenesis, clinical manifestations, and diagnosis of Waldenstrom macroglobulinemia. https://www.uptodate.com/contents/search. Accessed Nov. 3, 2025. Clinical manifestations, pathologic features, and diagnosis of lymphoplasmacytic lymphoma. https://www.uptodate.com/contents/search. Accessed Nov. 3, 2025. Treatment and prognosis of Waldenstrom macroglobulinemia. https://www.uptodate.com/contents/search. Accessed Nov. 3, 2025. Elsevier Point of Care. Clinical Overview: Waldenstrom macroglobulinemia. https://www.clinicalkey.com. Accessed Nov. 3, 2025. Ferri FF. Waldenstrom macroglobulinemia. In: Ferri's Clinical Advisor 2026. Elsevier; 2026. https://www.clinicalkey.com. Accessed Nov. 3, 2025. Nimmagadda R. EPSi. Mayo Clinic. May 5, 2022. Elsevier Point of Care. Clinical Overview: Hyperviscosity syndrome. https://www.clinicalkey.com. Accessed Nov. 3, 2025. Prognosis in Waldenstrom's macroglobulinemia. International Waldenstrom's Macroglobulinemia Foundation. https://iwmf.com/prognosis. Accessed Nov. 13, 2025. Related Associated Procedures Biological therapy for cancer Bone marrow biopsy Bone marrow transplant Cancer treatment Chemotherapy Complete blood count (CBC) CT scan Lumbar puncture (spinal tap) MRI Positron emission tomography scan Show more associated procedures Products & Services A Book: Mayo Clinic Family Health Book Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Waldenstrom macroglobulinemiaSymptoms&causesDiagnosis&treatmentSurvivalratesDoctors&departmentsCare atMayoClinic CON-20314000 Diseases & Conditions Waldenstrom macroglobulinemia