Overview

Ovarian hyperstimulation syndrome affects women taking injectable hormone medications to stimulate the development of eggs in the ovaries. This may occur in women undergoing in vitro fertilization (IVF), ovulation induction or intrauterine insemination.

Too much hormone medication in your system can lead to ovarian hyperstimulation syndrome (OHSS), in which your ovaries become swollen and painful. A small number of women may develop severe OHSS, which can cause rapid weight gain, abdominal pain, vomiting and shortness of breath.

Less often, OHSS happens during fertility treatments using medications you take by mouth, such as clomiphene (Clomid, Serophene). Occasionally OHSS occurs spontaneously, not related to fertility treatments.

Nov. 04, 2016
References
  1. Ovarian hyperstimulation syndrome. American Society for Reproductive Medicine. https://www.asrm.org/FACTSHEET_Ovarian_Hyperstimulation_Syndrome/. Accessed Aug. 29, 2016.
  2. Humaidan P, et al. Ovarian hyperstimulation syndrome: Review and new classification criteria for reporting in clinical trials. Human Reproduction. 2016;31:1997.
  3. Busso CE, et al. Pathogenesis, clinical manifestations, and diagnosis of ovarian hyperstimulation syndrome. http://www.uptodate.com/home. Accessed Aug. 29, 2016.
  4. Hoffman BL, et al. Treatment of the infertile couple. In: Williams Gynecology. 2nd ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://accessmedicine.com. Accessed Aug. 29, 2016.
  5. Kwik M, et al. Pathophysiology, treatment and prevention of ovarian hyperstimulation syndrome. Current Opinion in Obstetrics and Gynecology. 2016;28:236.
  6. Busso CE, et al. Management of ovarian hyperstimulation syndrome. http://www.uptodate.com/home. Accessed Aug. 29, 2016.
  7. D'Angelo A, et al. Coasting (withholding gonadotrophins) for preventing ovarian hyperstimulation syndrome. Cochrane Database of Systematic Reviews. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD002811.pub3/full. Accessed Aug. 29, 2016.