Overview By Mayo Clinic Staff Print Myxofibrosarcoma is a type of cancer that begins in the connective tissue. It tends to happen in the arms and legs. Myxofibrosarcoma starts as a growth of cells that can grow into healthy body tissue. Myxofibrosarcoma might cause a lump under the skin that grows slowly. It often isn't painful. This cancer happens most often in older adults. Myxofibrosarcoma is a type of soft tissue sarcoma. Soft tissue sarcomas are cancers that happen in the soft tissues that connect, support and surround other body structures. Request an appointment Diagnosis & treatment Dec. 24, 2025 Print Share on: FacebookTwitter Living with myxofibrosarcoma? Connect with others like you for support and answers to your questions in the Sarcoma support group on Mayo Clinic Connect, a patient community. Sarcoma Discussions FS-DFSP (Fibrosarcomatous dermatofibrosarcoma): Anyone else? 45 Replies Fri, Jun 05, 2026 chevron-right Undifferentiated Pleomorphic Sarcoma: Anyone else want to share? 134 Replies Sun, May 31, 2026 chevron-right Diagnosed with sarcoma? Let's share 1066 Replies Sun, May 24, 2026 chevron-right See more discussions Show references Roland CL, et al. Myxofibrosarcoma. Surgical Oncology Clinics of North America. 2016; doi:10.1016/j.soc.2016.05.008. Goldblum JR, et al. Borderline and malignant fibroblastic/myofibroblastic tumors. In: Enzinger and Weiss's Soft Tissue Tumors. 7th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Dec. 7, 2021. Cameron AM, et al. Management of soft tissue sarcoma. In: Current Surgical Therapy. 13th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Feb. 15, 2022. Radaelli S, et al. Treatment strategies and outcomes of primary myxofibrosarcomas in a large patients cohort. European Journal of Surgical Oncology. 2022; doi:10.1016/j.ejso.2022.01.003. Vanni S, et al. Myxofibrosarcoma landscape: Diagnostic pitfalls, clinical management and future perspectives. Therapeutic Advances in Medical Oncology. 2022; doi:10/1177/17588359221093973. Soft tissue sarcoma. Dorland's Medical Dictionary Online. https://www.dorlandsonline.com. Accessed Dec. 20, 2024. Myxofibrosarcoma. National Cancer Institute. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/myxofibrosarcoma. Accessed Dec. 20, 2024. Related Associated Procedures Cancer treatment Chemotherapy CT scan MRI Needle biopsy Radiation therapy Show more associated procedures Products & Services A Book: Mayo Clinic Family Health Book Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic MyxofibrosarcomaSymptoms&causesDiagnosis&treatmentDoctors&departments Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship Policy Opportunities Ad Choices Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. NEW: Mayo Clinic Guide to Better Sleep Listen to Health Matters Podcast Mayo Clinic on Incontinence The Essential Diabetes Book FREE Mayo Clinic Diet Assessment Mayo Clinic Health Letter - FREE book CON-20357210 Diseases & Conditions Myxofibrosarcoma