Myxofibrosarcoma

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Overview

Myxofibrosarcoma is a type of cancer that begins in the connective tissue. It tends to happen in the arms and legs.

Myxofibrosarcoma starts as a growth of cells that can grow into healthy body tissue. Myxofibrosarcoma might cause a lump under the skin that grows slowly. It often isn't painful. This cancer happens most often in older adults.

Myxofibrosarcoma is a type of soft tissue sarcoma. Soft tissue sarcomas are cancers that happen in the soft tissues that connect, support and surround other body structures.

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Diagnosis & treatment
Dec. 24, 2025
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Living with myxofibrosarcoma?

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Sarcoma Discussions

rond306
My biopsy is scheduled soon on my upper right thigh (sarcoma)

44 Replies Fri, Apr 24, 2026

jonezzi
Myxofibrosarcoma: What treatments did you have?

153 Replies Mon, Apr 13, 2026

Colleen Young, Connect Director
Diagnosed with sarcoma? Let's share

1064 Replies Mon, Apr 13, 2026

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  1. Roland CL, et al. Myxofibrosarcoma. Surgical Oncology Clinics of North America. 2016; doi:10.1016/j.soc.2016.05.008.
  2. Goldblum JR, et al. Borderline and malignant fibroblastic/myofibroblastic tumors. In: Enzinger and Weiss's Soft Tissue Tumors. 7th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Dec. 7, 2021.
  3. Cameron AM, et al. Management of soft tissue sarcoma. In: Current Surgical Therapy. 13th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Feb. 15, 2022.
  4. Radaelli S, et al. Treatment strategies and outcomes of primary myxofibrosarcomas in a large patients cohort. European Journal of Surgical Oncology. 2022; doi:10.1016/j.ejso.2022.01.003.
  5. Vanni S, et al. Myxofibrosarcoma landscape: Diagnostic pitfalls, clinical management and future perspectives. Therapeutic Advances in Medical Oncology. 2022; doi:10/1177/17588359221093973.
  6. Soft tissue sarcoma. Dorland's Medical Dictionary Online. https://www.dorlandsonline.com. Accessed Dec. 20, 2024.
  7. Myxofibrosarcoma. National Cancer Institute. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/myxofibrosarcoma. Accessed Dec. 20, 2024.

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