Print Departments and specialties Mayo Clinic has one of the largest and most experienced practices in the United States, with campuses in Arizona, Florida and Minnesota. Staff skilled in dozens of specialties work together to ensure quality care and successful recovery. Departments that treat this condition Cardiovascular Medicine Hematology Nephrology and Hypertension ResearchResearchers at Mayo Clinic coined the term monoclonal gammopathy of undetermined significance (MGUS) in the 1970s and continue to study this condition. The current research focuses on understanding how risk factors lead to the condition, how these factors might affect treatment, and how to prevent progression to blood cancers and other conditions. Healthcare professionals and scientists at the Mayo Clinic Comprehensive Cancer Center are working on improving the diagnosis and treatment of myeloma and other blood disorders. PublicationsSee a list of publications about (MGUS) by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine. Research Profiles Edit search filters close Narrow your search By location Arizona Florida Minnesota View all View all physicians • All Locations Kandasamy, Richard Ph.D. Minnesota Vachon, Celine M. Ph.D. Minnesota By Mayo Clinic Staff Monoclonal gammopathy of undetermined significance (MGUS) care at Mayo Clinic Request an appointment Diagnosis & treatmentCare at Mayo Clinic Dec. 30, 2025 Print Living with monoclonal gammopathy of undetermined significance (MGUS)? Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. Blood Cancers & Disorders Discussions Polycythemia Vera: Just been diagnosed 489 Replies Mon, Jun 01, 2026 chevron-right Living with MDS (Myelodyplastic Syndromes) 240 Replies Sun, May 31, 2026 chevron-right High Ferritin Levels: How can I lower my levels? 38 Replies Sat, May 30, 2026 chevron-right See more discussions Related Associated Procedures Bone marrow biopsy Complete blood count (CBC) Creatinine test X-ray Show more associated procedures Products & Services A Book: Mayo Clinic Family Health Book Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Monoclonal gammopathy of undetermined significance (MGUS)Symptoms&causesDiagnosis&treatmentDoctors&departmentsCare atMayoClinic Research: It's all about patients Show transcript for video Research: It's all about patients [MUSIC PLAYING] Joseph Sirven, M.D., Professor of Neurology, Mayo Clinic: Mayo's mission is about the patient. The patient comes first. So the mission and research here is to advance how we can best help the patient, how to make sure the patient comes first in care. So in many ways, it's a cycle. It can start with as simple as an idea worked on in a laboratory, brought to the patient bedside, and if everything goes right — and let's say it's helpful or beneficial — then brought on as a standard approach. And I think that is one of the unique characteristics of Mayo's approach to research — that patient-centeredness — that really helps to put it in its own spotlight. CON-20166978 Diseases & Conditions Monoclonal gammopathy of undetermined significance (MGUS)