Monoclonal gammopathy of undetermined significance (MGUS) care at Mayo Clinic

Your Mayo Clinic care team

Mayo Clinic's MGUS teams are led by hematologists and include other specialists as needed, such as nephrologists in cases of kidney failure and cardiology in cases of amyloid involving the heart.

Having all of this specialized expertise in a single place, focused on you, means that you're not just getting one opinion — care is discussed among the team, your test results are available quickly, and appointments are coordinated so that you can get answers in a matter of days.

Advanced diagnosis and treatment

Mayo Clinic has a long history of researching this condition, so its specialists have extensive experience distinguishing MGUS from related disorders. That's important in determining prognosis and treatment.

Expertise and rankings

  • Experience. Mayo Clinic's experts provide comprehensive care for more than 3,500 people with MGUS each year.
  • Predicting progression. Mayo Clinic has developed a risk-assessment model that can predict the risk of progression of MGUS to multiple myeloma.

Mayo Clinic in Rochester, Minn., Mayo Clinic in Phoenix/Scottsdale, Ariz., and Mayo Clinic in Jacksonville, Fla., are ranked among the Best Hospitals for cancer by U.S. News & World Report.

Locations, travel and lodging

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

For more information on visiting Mayo Clinic, choose your location below:

Costs and insurance

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.

In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals, or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Learn more about appointments at Mayo Clinic.

Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.

More information about billing and insurance:

Mayo Clinic in Arizona, Florida and Minnesota

Mayo Clinic Health System

July 22, 2021


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Monoclonal gammopathy of undetermined significance (MGUS)