Lymphoma staging By Mayo Clinic Staff If you're diagnosed with lymphoma, the next step is to determine the cancer's extent, called the stage. Imaging tests, blood tests and biopsies may be used to determine the stage of your lymphoma. Your healthcare team uses the cancer stage to help create your treatment plan. The stages of lymphoma may vary slightly depending on which type you have. Overall, the stages range from 1 to 4: Stage 1 lymphoma. At stage 1, lymphoma affects only one lymph node region or one site outside of the lymph nodes. Stage 2 lymphoma. A stage 2 lymphoma involves two or more lymph node regions on the same side of the diaphragm. Stage 3 lymphoma. At stage 3, lymphoma involves lymph node regions on both sides of the diaphragm. Stage 4 lymphoma. A stage 4 lymphoma involves regions outside of the lymph nodes. Lymphoma prognosisThe cancer prognosis tells you how likely it is that the cancer can be treated or cured. Your prognosis may depend on: Your age. Your overall health. The type of lymphoma you have. The cancer's stage. Your blood test results. Talk with your healthcare team about your prognosis if you want to know what to expect. Members of your healthcare team can explain what they consider when thinking about your prognosis. Request an appointment Diagnosis & treatmentSurvival rates Sept. 16, 2025 Share on: FacebookTwitter Living with lymphoma? Connect with others like you for support and answers to your questions in the CAR-T Cell Therapy support group on Mayo Clinic Connect, a patient community. CAR-T Cell Therapy Discussions My Bone Marrow Transplant (BMT/SCT) story: Will you share yours? 776 Replies Tue, Sep 16, 2025 chevron-right CAR-T cell Therapy: Joint and muscle pain 50 Replies Fri, Sep 05, 2025 chevron-right A Summary of My Multiple Myeloma 47 Replies Fri, Aug 29, 2025 chevron-right See more discussions Show references Hodgkin lymphoma treatment (PDQ) — Patient version. National Cancer Institute. https://www.cancer.gov/types/lymphoma/patient/adult-hodgkin-treatment-pdq. Accessed Aug. 6, 2025. Non-Hodgkin lymphoma treatment (PDQ) — Patient version. National Cancer Institute. https://www.cancer.gov/types/lymphoma/patient/adult-nhl-treatment-pdq. Accessed Aug. 6, 2025. Primary CNS lymphoma treatment (PDQ) — Patient version https://www.cancer.gov/types/lymphoma/patient/primary-cns-lymphoma-treatment-pdq. Accessed Aug. 6, 2025. Mycosis fungoides (including Sezary Syndrome) treatment (PDQ) — Patient version https://www.cancer.gov/types/lymphoma/patient/mycosis-fungoides-treatment-pdq. Accessed Aug. 6, 2025. Cancer stat facts: Non-Hodgkin lymphoma. National Cancer Institute. https://seer.cancer.gov/statfacts/html/nhl.html. Accessed Aug. 6, 2025. Cancer stat facts: Hodgkin lymphoma. National Cancer Institute. https://seer.cancer.gov/statfacts/html/hodg.html. Accessed Aug. 6, 2025. Elsevier Point of Care. Clinical Overview: Hodgkin lymphoma. https://www.clinicalkey.com. Accessed Aug. 6, 2025. Elsevier Point of Care. Clinical Overview: Non-Hodgkin lymphoma. https://www.clinicalkey.com. Accessed Aug. 6, 2025. Niederhuber JE, et al., eds. Abeloff's Clinical Oncology. 6th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Aug. 6, 2025. Larson RA, et al. Tumor lysis syndrome: Prevention and treatment. https://www.uptodate.com/contents/search. Accessed Aug. 6, 2025. Elsevier Point of Care. Clinical Overview: Febrile neutropenia in adults. https://www.clinicalkey.com. Accessed Aug. 6, 2025. Robetorye R, et al. Incorporation of digital gene expression profiling for cell-of-origin determination (Lymph2Cx Testing) into the routine work-up of diffuse large B-cell lymphoma. Journal of Hematopathology. 2019; doi:10.1007/s12308-019-00344-0. Laurent C, et al. Impact of expert pathologic review of lymphoma diagnosis: Study of patients from the French Lymphopath Network. Journal of Clinical Oncology. 2017; doi:10.1200/JCO.2016.71.2083. Member institutions. Alliance for Clinical Trials in Oncology. https://www.allianceforclinicaltrialsinoncology.org/main/public/standard.xhtml?path=%2FPublic%2FInstitutions. Accessed Aug. 6, 2025. Membership institution lists. NRG Oncology. https://www.nrgoncology.org/About-Us/Membership/Member-Institution-Lists. Accessed Aug. 6, 2025. Related Lymph node clusters Lymphoma FAQs What is lymphoma? An expert explains Associated Procedures Biological therapy for cancer Bone marrow transplant Cancer treatment CAR-T cell therapy Chemotherapy CT scan MRI Positron emission tomography scan Radiation therapy Radiopharmaceuticals Show more associated procedures News from Mayo Clinic Mayo Clinic Minute: How precise diagnosis of lymphoma offers patients best treatment options Jan. 26, 2024, 05:00 p.m. CDT Products & Services A Book: Living Medicine LymphomaSymptoms&causesDiagnosis&treatmentStagesSurvivalratesDoctors&departmentsCare atMayoClinic CON-20304579 Diseases & Conditions Lymphoma