Peutz-Jeghers syndrome

Peutz-Jeghers syndrome care at Mayo Clinic

People with Peutz-Jeghers syndrome who seek care at Mayo Clinic will find dedicated specialists who offer expert, personalized care using the latest innovations.

Your Mayo Clinic care team

Mayo Clinic specialists are experienced in all aspects of treating Peutz-Jeghers syndrome (PJS), from genetic screening and counseling to surgery. If you're at risk of PJS, Mayo Clinic specialists take time to talk about your options with you. Pediatric specialists closely monitor at-risk children. Specialists in the Gastrointestinal Neoplasia Clinic evaluate and treat adults with PJS, including those with polyps and cancer. If you have PJS, Mayo Clinic specialists collaborate with consulting physicians, surgeons and your primary healthcare professional to form the right treatment plan for you.

Having all this expertise in a single place means that your care is discussed among the team, test results are available quickly, appointments are scheduled in coordination and the most highly specialized experts in the world are all working together for your health.

Advanced diagnosis and treatment

Familial cancer syndromes — cancers that are hereditary — are rare. It's important to seek evaluation from doctors familiar with your cancer. Mayo Clinic's highly trained specialists are experienced in the diagnosis and treatment of all familial cancer syndromes.

• Genetic testing. Mayo Clinic's Familial Cancer Program is staffed by experts from several fields who work together to ensure you receive exactly the care you need. Professionals who work in the Familial Cancer Program include specialists in genetic counseling and doctors with expertise in hereditary cancer syndromes.

  At Mayo Clinic, you have access to the latest screening methods, including genetic testing, to determine if you have PJS. Genetics counselors discuss the pluses and minuses of testing with you, including the psychological and medical implications and confidentiality issues. If you choose genetic testing, your counselor and your doctor discuss the results with you.

  The Molecular Genetics Laboratory uses the latest techniques to detect specific mutations in the STK11 gene linked to PJS. If the initial genetic test is negative, Mayo scientists may be able to sequence other genes that can cause similar symptoms.

  The Colon Cancer Family Registry uses biospecimens and data from thousands of families to identify colorectal cancer susceptibility genes, analyze gene interactions in causes of colorectal cancer, and translate research findings to better colorectal cancer prevention and treatment.

• Cutting-edge treatments. For those who have polyps or cancer, Mayo Clinic offers state-of-the-art endoscopic, operative, radiation and medical treatments.
• Minimally invasive colorectal surgery. At Mayo Clinic, colorectal surgeons use minimally invasive, also called laparoscopic, techniques whenever possible to treat even very large polyps and early cancers.

Expertise and rankings

The top experts at Mayo Clinic have extensive experience caring for people with Peutz-Jeghers syndrome. Experts work in teams to provide you with exactly the care you need.

At Mayo Clinic, you can expect:

• Experience you can trust. Specialists at Mayo Clinic have experience treating people with rare hereditary polyp disorders, including Peutz-Jeghers syndrome, Lynch syndrome, familial adenomatous polyposis (FAP) juvenile polyposis, Cowden disease and Cronkhite-Canada syndrome. Comprehensive, multidisciplinary care brings together specialists in gastroenterology, genetics, oncology, surgery and pathology, especially through Mayo's Early-Onset and Hereditary GI Cancers Program.
• Leading research. Mayo Clinic researchers are working to discover more genetic changes that cause hereditary polyp disorders and to improve diagnosis and treatment. Specific efforts include developing enhanced screening methods for hereditary polyp disorders.

Nationally recognized expertise

Mayo Clinic in Rochester, Minnesota, ranks No. 1 for digestive disorders in the U.S. News & World Report Best Hospitals rankings. Mayo Clinic in Phoenix/Scottsdale, Arizona, and Mayo Clinic in Jacksonville, Florida, are ranked among the Best Hospitals for digestive disorders by U.S. News & World Report. Mayo Clinic Children's in Rochester is ranked the No. 1 hospital in Minnesota and the five-state region of Iowa, Minnesota, North Dakota, South Dakota and Wisconsin, according to U.S. News & World Report's 2025–2026 "Best Children's Hospitals" rankings.

Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Jacksonville, Florida, and Mayo Clinic in Phoenix/Scottsdale, Arizona, are ranked among the Best Hospitals for cancer by U.S. News & World Report.

Mayo Clinic Comprehensive Cancer Center meets the strict standards for a U.S. National Cancer Institute comprehensive cancer center. These standards recognize scientific excellence and a multispecialty approach focused on cancer prevention, diagnosis and treatment.

Locations, travel and lodging

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

For more information on visiting Mayo Clinic, choose your location below:

Costs and insurance

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.

In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Learn more about appointments at Mayo Clinic.

Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.