Treatment

If you've tried over-the-counter (nonprescription) acne products for several weeks and they haven't helped, ask your doctor about prescription-strength medications. A dermatologist can help you:

  • Control your acne
  • Avoid scarring or other damage to your skin
  • Make scars less noticeable

Acne medications work by reducing oil production and swelling or by treating bacterial infection. With most prescription acne drugs, you may not see results for four to eight weeks. It can take many months or years for your acne to clear up completely.

The treatment regimen your doctor recommends depends on your age, the type and severity of your acne, and what you are willing to commit to. For example, you may need to wash and apply medications to the affected skin twice a day for several weeks. Topical medications and drugs you take by mouth (oral medication) are often used in combination. Treatment options for pregnant women are limited due to the risk of side effects.

Talk with your doctor about the risks and benefits of medications and other treatments you are considering. And make follow-up appointments with your doctor every three to six months until your skin improves.

Topical medications

The most common topical prescription medications for acne are:

  • Retinoids and retinoid-like drugs. Drugs that contain retinoic acids or tretinoin are often useful for moderate acne. These come as creams, gels and lotions. Examples include tretinoin (Avita, Retin-A, others), adapalene (Differin) and tazarotene (Tazorac, Avage, others). You apply this medication in the evening, beginning with three times a week, then daily as your skin becomes used to it. It prevents plugging of hair follicles. Do not apply tretinoin at the same time as benzoyl peroxide.

    Topical retinoids increase your skin's sun sensitivity. They can also cause dry skin and redness, especially in people with skin of color. Adapalene may be tolerated best.

  • Antibiotics. These work by killing excess skin bacteria and reducing redness and inflammation. For the first few months of treatment, you may use both a retinoid and an antibiotic, with the antibiotic applied in the morning and the retinoid in the evening. The antibiotics are often combined with benzoyl peroxide to reduce the likelihood of developing antibiotic resistance. Examples include clindamycin with benzoyl peroxide (Benzaclin, Duac, others) and erythromycin with benzoyl peroxide (Benzamycin). Topical antibiotics alone aren't recommended.
  • Azelaic acid and salicylic acid. Azelaic acid is a naturally occurring acid produced by a yeast. It has antibacterial properties. A 20% azelaic acid cream or gel seems to be as effective as many conventional acne treatments when used twice a day. Prescription azelaic acid (Azelex, Finacea) is an option during pregnancy and while breast-feeding. It can also be used to manage discoloration that occurs with some types of acne. Side effects include skin redness and minor skin irritation.

    Salicylic acid may help prevent plugged hair follicles and is available as both wash-off and leave-on products. Studies showing its effectiveness are limited. Side effects include skin discoloration and minor skin irritation.

  • Dapsone. Dapsone (Aczone) 5% gel twice daily is recommended for inflammatory acne, especially in women with acne. Side effects include redness and dryness.

Evidence is not strong in support of using zinc, sulfur, nicotinamide, resorcinol, sulfacetamide sodium or aluminum chloride in topical treatments for acne.

Oral medications

  • Antibiotics. For moderate to severe acne, you may need oral antibiotics to reduce bacteria. Usually the first choice for treating acne is a tetracycline (minocycline, doxycycline) or a macrolide (erythromycin, azithromycin). A macrolide might be an option for people who can't take tetracyclines, including pregnant women and children under 8 years old.

    Oral antibiotics should be used for the shortest time possible to prevent antibiotic resistance. And they should be combined with other drugs, such as benzoyl peroxide, to reduce the risk of developing antibiotic resistance.

    Severe side effects from the use of antibiotics to treat acne are uncommon. These drugs do increase your skin's sun sensitivity.

  • Combined oral contraceptives. Four combined oral contraceptives are approved by the FDA for acne therapy in women who also wish to use them for contraception. They are products that combine progestin and estrogen (Ortho Tri-Cyclen 21, Yaz, others). You may not see the benefit of this treatment for a few months, so using other acne medications with it for the first few weeks may help.

    Common side effects of combined oral contraceptives are weight gain, breast tenderness and nausea. These drugs are also associated with increased risk of cardiovascular problems, breast cancer and cervical cancer.

  • Anti-androgen agents. The drug spironolactone (Aldactone) may be considered for women and adolescent girls if oral antibiotics aren't helping. It works by blocking the effect of androgen hormones on the oil-producing glands. Possible side effects include breast tenderness and painful periods.
  • Isotretinoin. Isotretinoin (Amnesteem, Claravis, others) is a derivative of vitamin A. It may be prescribed for people whose moderate or severe acne hasn't responded to other treatments.

    Potential side effects of oral isotretinoin include inflammatory bowel disease, depression and severe birth defects. All people receiving isotretinoin must participate in an FDA-approved risk management program. And they'll need to see their doctors regularly to monitor for side effects.

Therapies

For some people, the following therapies might be helpful, either alone or in combination with medications.

  • Light therapy. A variety of light-based therapies have been tried with some success. Most will require multiple visits to your doctor's office. Further study is needed to determine the ideal method, light source and dose.
  • Chemical peel. This procedure uses repeated applications of a chemical solution, such as salicylic acid, glycolic acid or retinoic acid. This treatment is for mild acne. It might improve the appearance of the skin, though the change is not long lasting and repeat treatments are usually needed.
  • Drainage and extraction. Your doctor may use special tools to gently remove whiteheads and blackheads (comedos) or cysts that haven't cleared up with topical medications. This technique temporarily improves the appearance of your skin, but it might also cause scarring.
  • Steroid injection. Nodular and cystic lesions can be treated by injecting a steroid drug into them. This therapy has resulted in rapid improvement and decreased pain. Side effects may include skin thinning and discoloration in the treated area.

Treating children

Most studies of acne drugs have involved people 12 years of age or older. Increasingly, younger children are getting acne as well. The FDA has expanded the number of topical products approved for use in children. And guidelines from the American Academy of Dermatology indicate that topical benzoyl peroxide, adapalene and tretinoin in preadolescent children are effective and don't cause increased risk of side effects.

If your child has acne, consider consulting a pediatric dermatologist. Ask about drugs to avoid in children, appropriate doses, drug interactions, side effects, and how treatment may affect a child's growth and development.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this disease.

Alternative medicine

Some alternative and integrative medicine approaches might be helpful in reducing acne:

  • Tea tree oil. Gels containing at least 5% tea tree oil may be as effective as lotions containing 5% benzoyl peroxide, although tea tree oil might work more slowly. Possible side effects include minor itching, burning, redness and dryness, which make it a poor choice for people with rosacea.
  • Brewer's yeast. A strain of brewer's yeast called Hansen CBS seems to help decrease acne when taken orally. It may cause gas (flatulence).

More research is needed to establish the potential effectiveness and long-term safety of these and other integrative approaches, such as biofeedback and ayurvedic compounds. Talk with your doctor about the pros and cons of specific treatments before you try them.

Lifestyle and home remedies

You can try to avoid or control mild or moderate acne with nonprescription products, good basic skin care and other self-care techniques:

  • Wash problem areas with a gentle cleanser. Twice a day, use your hands to wash your face with mild soap or a gentle cleanser (Cetaphil, Vanicream, others) and warm water. If your hair is oily, shampoo every day. And be gentle if you're shaving affected skin.

    Avoid certain products, such as facial scrubs, astringents and masks. They tend to irritate the skin, which can worsen acne. Too much washing and scrubbing also can irritate the skin.

  • Try over-the-counter acne products to dry excess oil and promote peeling. Look for products containing benzoyl peroxide as the active ingredient. You might also try products containing salicylic acid, glycolic acid or alpha hydroxy acids. It may take a few weeks of using a product before you see any improvement.

    Creams are less irritating than gels or ointments. Nonprescription acne medications may cause initial side effects — such as redness, dryness and scaling — that often improve after the first month of using them.

  • Avoid irritants. Oily or greasy cosmetics, sunscreens, hairstyling products or acne concealers can worsen acne. Instead, use products labeled water-based or noncomedogenic, which means they are less likely to cause acne.
  • Protect your skin from the sun. For some people, the sun worsens the discoloration that sometimes lingers after the acne has cleared. And some acne medications make you more susceptible to sunburn. Check with your doctor to see if your medication is one of these. If it is, stay out of the sun as much as possible. Regularly use a nonoily (noncomedogenic) moisturizer that includes a sunscreen.
  • Avoid friction or pressure on your skin. Protect your acne-prone skin from contact with items such as phones, helmets, tight collars or straps, and backpacks.
  • Avoid touching or picking acne-prone areas. Doing so can trigger more acne or lead to infection or scarring.
  • Shower after strenuous activities. Oil and sweat on your skin can lead to breakouts.

Coping and support

Acne and acne scars can cause anxiety and may affect your social relationships and self-image. Sometimes it can help to talk with your family, a support group or a counselor.

Stress can worsen acne. Try to manage stress by getting enough sleep and practicing relaxation techniques.

Preparing for your appointment

If you have acne that's not responding to self-care and over-the-counter treatments, make an appointment with your doctor. Early, effective treatment of acne reduces the risk of scarring and of lasting damage to your self-esteem. After an initial examination, your doctor may refer you to a specialist in the diagnosis and treatment of skin conditions (dermatologist).

Here's some information to help you get ready for your appointment.

What you can do

  • List your key medical information, such as other conditions you're dealing with and any prescription or over-the-counter products you're using, including vitamins and supplements.
  • List key personal information, including any major stresses or recent life changes.
  • List questions to ask your doctor. Creating your list of questions in advance can help you make the most of your time with your doctor.

Below are some basic questions to ask your doctor about acne. If any additional questions occur to you during your visit, don't hesitate to ask.

  • What treatment approach do you recommend for me?
  • If the first treatment doesn't work, what will you recommend next?
  • What are the possible side effects of the medications you're prescribing?
  • How long can I safely use the medications you're prescribing?
  • How soon after beginning treatment might my symptoms start to improve?
  • When will you see me again to evaluate whether my treatment is working?
  • Is it safe to stop my medications if they don't seem to be working?
  • What self-care steps might improve my symptoms?
  • Do you recommend any changes to my diet?
  • Do you recommend any changes to the over-the-counter products I'm using on my skin, including soaps, lotions, sunscreens and cosmetics?

What to expect from your doctor

Your doctor is likely to ask you a number of questions. Being ready to answer them may reserve time to go over any points you want to talk about in-depth. Your doctor may ask:

  • When did you first develop this problem?
  • Does anything in particular seem to trigger an acne flare, such as stress or — in girls and women — your menstrual cycle?
  • What medications are you taking, including over-the-counter and prescription drugs as well as vitamins and supplements?
  • In girls and women: Do you use oral contraceptives?
  • In girls and women: Do you have regular menstrual periods?
  • In girls and women: Are you pregnant, or do you plan to become pregnant soon?
  • What types of soaps, lotions, sunscreens, hair products or cosmetics do you use?
  • How is acne affecting your self-esteem and your confidence in social situations?
  • Do you have a family history of acne?
  • What treatments and self-care steps have you tried so far? Have any been effective?
  • Have other family members had isotretinoin treatment or hormone therapy to treat their acne? Has it been effective?
Sept. 12, 2020
  1. AskMayoExpert. Acne. Mayo Clinic; 2019.
  2. American Academy of Dermatology. Guidelines of care for the management of acne vulgaris. https://doi.org/10.1016/j.jaad.2015.12.037.
  3. Alpha hydroxyl acids (AHAs). Natural Medicines. https://naturalmedicines.therapeuticresearch.com. Accessed July 9, 2020.
  4. Rakel D, ed. Acne vulgaris and acne rosacea. In: Integrative Medicine. 4th ed. Elsevier; 2018. https://www.clinicalkey.com. Accessed Sept. 5, 2017.
  5. Dinulos JGH. Acne, rosacea, and related disorders. Habif's Clinical Dermatology. 7th ed. Elsevier; 2021. https://www.clinicalkey.com. Accessed July 6, 2020.
  6. Acne. National Institute of Arthritis and Musculoskeletal and Skin Diseases. https://www.niams.nih.gov/health-topics/acne. Accessed July 9, 2020.
  7. Graber E. Treatment of acne vulgaris. https://www.uptodate.com/contents/search. Accessed July 9, 2020.
  8. Thiboutot D, et al. Pathogenesis, clinical manifestations and diagnosis of acne vulgaris. https://www.uptodate.com/contents/search. Accessed July 9, 2020.
  9. Kermott CA, et al., eds. Acne. In: Mayo Clinic Book of Home Remedies. 2nd ed. Time; 2017.
  10. Maymone M, et al. Common skin disorders in pediatric skin of color. Journal of Pediatric Health Care. 2019; doi:10.1016/j.pedhc.2019.04.019.
  11. Matthes BM, et al. Intralesional corticosteroid injection. https://www.uptodate.com/contents/search. Accessed July 8, 2020.
  12. Gibson LE (expert opinion). Mayo Clinic. July 20, 2020.