Otolaryngology (ENT)/Head and Neck Surgery

Below are current clinical trials.

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1. A Study to Assess Sinus Stenting to Manage Cerebrospinal Fluid Leak

   Rochester, Minn.

   The purpose of this study is to determine whether transverse/sigmoid sinus junction stenting reduces the risk of recurrent cerebrospinal fluid (CSF) leak in patients with idiopathic intracranial hypertension presenting with CSF leak.

    

2. A Study to Evaluate the Effectiveness of a Dexamethasone Eluting Slim Modiolar Electrode in the Reduction of Fibrosis in a Newly Implanted Adult Population with Bilateral, Post-Linguistic, Moderate to Profound Sensorineural Hearing Loss

   Rochester, Minn.

   The purpose of this study is show the effectiveness of a dexamethasone eluting electrode in an adult population with post-lingual, bilateral, moderate to profound sensorineural hearing loss in the reduction of fibrosis (as measured by impedance) when compared to a conventional, non-dexamethasone eluting electrode and in the improvement of speech recognition from preoperative baseline.

3. A Study to Evaluate The Use of Intravenous Fluorescein Sodium (FS) and YELLOW 560 nm Microscope Filter (YE560) During Surgery for Vestibular Schwannomas (VS)

   Rochester, Minn.

   The purpose of this study is to evaluate the benefit of using intravenous fluorescein sodium (FS) and YELLOW 560 nm microscope filter (YE560) during surgery for vestibular schwannomas (VS), Meningioma, Head and Neck Paraganglioma, or Head and Neck Schwannoma and to determine the optimum FS dose and timing to be used with the YE560 device.

4. Epidemiologic and Psychologic Factors for Spasmotic Dsyphonia (SD)

   Jacksonville, Fla.

   The purpose of this study is to investigate the epidemiologic and psychologic factors for spasmotic dsyphonia (SD).   

5. A Study to Evaluate the Relationship of a Predictive Gag Survey and Patient’s Gag Reflex in Flexible Laryngoscopy

   Rochester, Minn.

   The primary purpose of this study is to assess the correlation between the predictive gag survey (PGS) and a provider-completed GSI  in patients undergoing nasolaryngoscopy. 

6. A Study Assessing Robotic Surgery in the Seated Position for Benign and Malignant Lesions of the Head and Neck Using the da Vinci Robotic Surgical System

   Rochester, Minn.

   This study is designed to investigate if transoral surgery with the patient in the seated position utilizing the da Vinci® Robotic Surgical System (Intuitive Surgical, Inc., Sunnyvale, CA) will enable better visualization and expedited removal of benign and malignant tumors of the throat.

7. A Study to Identify Biomarkers in the Blood, Saliva or Tissue for Oropharyngeal Squamous Cell Cancer

   Rochester, Minn.

   The purpose of this study is to identify a biomarker (or biomarkers) that is present when disease is present (i.e., at diagnosis or recurrence) and not present when disease is absent (i.e., after treatment, in HPV negative patients or in normal controls).

8. A Study to Evaluate Quality of Life Outcomes for Cholesteatoma

   Rochester, Minn.

   The purpose of this study is to determine the quality of life scores for patients that have undergone subtotal petrosectomy and ear canal closure for cholesteatoma and/or chronic otitis media utilizing two previously validated quality-of-life scales.

9. Quality of Life in Patients with Acoustic Neuromas

   Rochester, Minn.

   Acoustic neuromas (also known as vestibular schwannomas) are benign slow growing tumors that arise from the vestibular portion of the eighth cranial nerve. Current treatment options include microsurgery, stereotactic radiosurgery and observation, using a “wait-and-scan” approach. The primary objective of this study is to compare long-term quality of life outcomes between treatments for sporadic acoustic neuromas.

10. Novel Tinnitus Implant System for the Treatment of Chronic Severe Tinnitus

    Rochester, Minn.

    The purpose of this study is to evaluate the feasibility of implementing a novel Tinnitus Implant System for suppression of chronic intractable tinnitus.