Otolaryngology (ENT)/Head and Neck Surgery

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Study to Compare Middle Ear Mechanics in Individuals with Unilateral Otosclerosis, and Unilateral and Bilateral Cochlear Implant Recipients

   Rochester, Minn.

   The purpose of this study is to measure the changes in the middle ear mechanics or the transfer function in cochlear implant recipients and compare those changes with the middle ear transfer function measured in individuals with unilateral otosclerosis.

2. Vocal Disorders Co-existing in Patients with Spasmotic Dsyphonia (SD)

   Jacksonville, Fla.

   The purpose of this study is to investigate if SD patients have vocal disorders (nodules, polyps, muscle tension dysphonia etc) more than in normal population.

3. A Study of the Biological System of Allergic Fungal Sinusitis Mucin

   Jacksonville, Fla.

   The purpose of this study is to describe the proteome of mucus in patients without chronic rhinosinusitis (nCRS) with an emphasis on cytokines and bone morphogenic proteins present (BMPs), to describe the proteome of mucus in patients with chronic rhinosinusitis without polyps (CRSsNP) with an emphasis on cytokines and BMPs present, to describe the proteome of mucus in patients with allergic fungal sinusitis (AFRS) with an emphasis on cytokines and BMPs present, and to identify BMPs differentially elevated in patients with AFRS compared to patients with nCRS or CRS.

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4. Study of Auditory Function through Intra- and Post-operative Measurements

   Rochester, Minn.

   The purpose of this study is to determine if electrocochleography (ECochG) measurements performed during cochlear implant surgery can be used to monitor cochlear structures and minimize electrode insertion trauma.

5. A Study to Evaluate Ability of Hearing Aids and Wearable Sensors to Detect Falls

   Rochester, Minn.

   The purpose of this study is to evaluate the sensitivity and specificity of Livio© hearing aids and Apple Watch© to detect falls when subjects with normal/abnormal vestibular function experience controlled, postural disturbances on a treadmill. We will also assess the interaction mechanism of vestibulocolic and vestibulospinal reflex in fall prevention.

6. A Study to Evaluate Impedance Monitoring in Cochlear Implants

   Rochester, Minn.

   The purpose of this study is to determine changes in cochlear implant electrode impedances as a function over a period of time.

7. A Study of Simulated Sylvian Fissure Dissection Under Subarachnoid Hemorrhage Conditions Using a Rodent Microvascular Anastomosis Model

   Rochester, Minn.

   The purpose of this study is to assess the differences in microvascular anastomosis outcomes between the experiment aneurysmal subarachnoid hemorrhage (aSAH)-like conditions and control animals.

8. A Study to Evaluate the Effect of Medical Intervention on Sinonasal Inflammation in Patients with Chronic Sinusitis, Nasal Polyps and Positive Sinus Culture

   Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

   The purpose of this study is to compare change in SNOT-22 score in patients who received medication therapy such as oral antibiotics, topical antibiotics, oral corticosteroids, topical corticosteroids, leukotriene receptor antagonist, and interleukin 5 receptor antagonist following endoscopic sinus surgery versus control in patient with chronic sinusitis with nasal polyps and a positive culture.

9. A Study to Develop Processes for Tissue Growth for Use in Reconstruction Surgeries

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to develop the procedures for the growth of specific cells and tissues needed for reconstruction surgeries of the head and neck using the waste tissues of other surgeries.

10. A Study of the Use of a Human Nerve Allograft in Laryngeal Reinnervation

    Jacksonville, Fla.

    The purpose of this study is to prove/disprove that human nerve allograft to recurrent laryngeal nerve anastomosis will restore vocal cord movement.