Clinical trials Below are current clinical trials.24 studies in Otolaryngology (ENT)/Head and Neck Surgery (open studies only). Filter this list of studies by location, status and more. Study Of Zanzalintinib In Combination With Immuno-Oncology Agents In Participants With Solid Tumors Jacksonville, Fla., Rochester, Minn., Scottsdale/Phoenix, Ariz. This is a multicenter Phase 1b, open label, dose-escalation and cohort-expansion study, evaluating the safety, tolerability, pharmacokinetics (PK), preliminary antitumor activity, and effect of biomarkers of zanzalintinib administered alone, and in combination with nivolumab (doublet), nivolumab + ipilimumab (triplet) and nivolumab + relatlimab (triplet) in participants with advanced solid tumors.In the Expansion Stage, the safety and efficacy of zanzalintinib as monotherapy and in combination therapy will be further evaluated in tumor-specific Expansion Cohorts. A Study to Develop Processes for Tissue Growth for Use in Reconstruction Surgeries Scottsdale/Phoenix, Ariz. The purpose of this study is to develop the procedures for the growth of specific cells and tissues needed for reconstruction surgeries of the head and neck using the waste tissues of other surgeries. Airway Stenosis Specimen Registry Rochester, Minn., Jacksonville, Fla. The primary objective of this proposal is to develop an Airway Stenosis Registry at Mayo Clinic. The purpose of the registry will be to support ongoing research in the etiology, early diagnosis, clinical management, and prognosis of airway stenosis due to inflammation, cancers and other diseases of the airway. A Study to Evaluate the Effects of Sharpened Romberg Testing (SRT) in Healthy Subjects Scottsdale/Phoenix, Ariz. The purpose of this study is to evaluate the effects of hypocapnia on postural standing balance using the sharpened Romberg test (SRT). Pagination Clinical studies PrevPrevious Page Go to page 11 Go to page 22 Go to page 33 Request an appointment Specialty groupsResearch Jan. 17, 2026 Share on: FacebookTwitter Show references Otolaryngology (ENT)/Head and Neck SurgerySectionsRequest an appointmentOverviewTests & proceduresConditions treatedDoctorsDoctors by location and specialtySpecialty groupsClinical trialsResearchPatient storiesCosts & insuranceNews from Mayo ClinicReferrals Research: It's all about patients Show transcript for video Research: It's all about patients [MUSIC PLAYING] Joseph Sirven, M.D., Professor of Neurology, Mayo Clinic: Mayo's mission is about the patient. The patient comes first. So the mission and research here is to advance how we can best help the patient, how to make sure the patient comes first in care. So in many ways, it's a cycle. It can start with as simple as an idea worked on in a laboratory, brought to the patient bedside, and if everything goes right — and let's say it's helpful or beneficial — then brought on as a standard approach. And I think that is one of the unique characteristics of Mayo's approach to research — that patient-centeredness — that really helps to put it in its own spotlight. SectionsRequest an appointmentOverviewTests & proceduresConditions treatedDoctorsDoctors by location and specialtySpecialty groupsClinical trialsResearchPatient storiesCosts & insuranceNews from Mayo ClinicReferrals ORG-20424058 Medical Departments & Centers Otolaryngology (ENT)/Head and Neck Surgery