Allergic Diseases

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Study of Eosinophil Activities in Healthy Subjects and Subjects with Allergic/immunologic Disorders

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to investigate eosinophil activities and interactions with other cell types in vitro to better understand how they contribute to health and disease.  Specifically, we will isolate eosinophils and other white blood cells from peripheral blood and subject them to various stimuli as well as co-culture conditions to examine activities and interactions. 

2. Collection of Tissue and Blood in Patients with Allergic and Immunologic Disorders

   Scottsdale/Phoenix, Ariz.

   Allergic and immunologic disorders are very common but some are very poorly understood. Numerous studies of the epidemiology, characteristics, diagnosis and treatment of these disorders are urgently needed to identify and optimally treat affected patients. Though numerous challenges impact the progress of research in this area, specimens are needed to test new hypotheses and methodologies.  We aim to create a registry and biorepository of tissue and fluid specimens for future studies.

3. Study to Identify Allergen Epitopes in Individuals with Peanut Allergy

   Jacksonville, Fla.

   The purpose of this study is to use samples from multiple patients to validate and provide detailed mapping of food to identify allergen epitopes.  This will provide crucial data to the study of the molecular basis of food allergy.

4. Nasal Sinus Specimen Collection (NSSC) Project

   Rochester, Minn.

   This study is being done in order to gain a greater understanding of rhinitis and sinusitis conditions and to improve diagnostic and treatment options for these conditions.

5. Participation in a Research Registry for Immune Disorders

   Rochester, Minn.

   The purpose of this study is to build a National Registry of individuals with one of the group of primary immune deficiency diseases. A "Registry" is a list of basic information about people who have a certain disease or condition in common. These immune deficiency diseases are thought to be rare and include: Severe combined immunodeficiency (SCID), leukocyte adhesion deficiency (LAD), X-linked Agammaglobulinemia (XLA), common variable immune deficiency (CVID), DiGeorge syndrome (DGS), Hyper IgM syndrome (HIGM), Wiskott Aldrich syndrome (WAS) and chronic granulomatous disease (CGD). We would like to contribute data on a number of subjects with these relatively rare diseases to this National Registry Data Base. The information will be age, sex, race or ethnic group, immunologic lab tests that were used to diagnose the condition, what complications may have occurred since the condition started, lung disease, blood changes, etc. and the results of various treatments used. The goal is to discover basic outcome data, ethnic, racial characteristics, kind of complications and useful treatments. You will not be contacted by anyone unless you authorize it. If a new study about you (or your child’s) immune defect comes up, your doctor will be notified, who can then share this with you to find out if you are interested in participating or not. Alternatively you may elect to be contacted directly by the Registry to determine your interest in participation.

6. A Study Identifying Blood Serum Markers of the Immune System Affecting Different Features of Chronic Rhinosinusitis

   Rochester, Minn.

   The purpose of this study is to find out what immune system processes cause the chronic inflammation that happens with chronic rhinosinusitis (CRS) and if there are different immune system pathways involved among CRS patients.

7. Study to Analyze the Metabolic Environment in Preventing Atopic Dermatitis

   Rochester, Minn.

   The purpose of this study is to compare the assessment of the composition of the fecal, nasal,oral and skin microbiota in patients with AD (cases) as compared to age/sex and diet matched control children without atopic dermatitis, and to apply mass-spectrometry-based metabolomic approach to analyzing fecal, nasal, oral and skin samples from cases, in order to characterize their biochemical metabolic profiles by comparison with those of their controls.

8. A Study of Biomarkers for the Diagnosis of Mastocytosis

   Rochester, Minn.

   The purpose of this study is to identify biomarkers that can show differences in mast cell disease (Mastocytosis) status and activity for help with diagnosis and prognosis.

9. Evaluation of Immunophenotype Signatures in Hypereosinophilia-Associated Disorders

   Rochester, Minn.

   The purpose of this study is to characterize the immunophenotype of individuals with hypereosinophilia-associated cardiovascular, gastrointestinal, hematologic, and respiratory disorders.

10. Excretion of Mast Cell Mediators in Children with Allergic Disorders

    Rochester, Minn.

    The aim of this study is to examine the role of mast cell mediators in children with allergic disorders in a two part study. Part 1 of the study will prospectively obtain the values of mast cell mediators, including 2,3 dinor 11β-PGF2α, n-MH, and LTE4 in the urine of a healthy pediatric reference population. Part 2 of the study will prospectively evaluate the urine concentrations of mast cell mediators in a cohort of pediatric allergic disorder patients including asthma, allergic rhinoconjunctivitis, eczema, urticaria, systemic anaphylaxis, and mast cell disorders, as well as POTS (postural orthostatic tachycardia syndrome). Comparisons of these values in the disease cohort will be made utilizing the pediatric expected reference intervals established in Part 1. Further analysis will determine if one or several urine mast cell mediators are elevated in a particular allergic disorder.