Allergic Diseases

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Collection of Tissue and Blood in Patients with Allergic and Immunologic Disorders

   Scottsdale/Phoenix, Ariz.

   Allergic and immunologic disorders are very common but some are very poorly understood. Numerous studies of the epidemiology, characteristics, diagnosis and treatment of these disorders are urgently needed to identify and optimally treat affected patients. Though numerous challenges impact the progress of research in this area, specimens are needed to test new hypotheses and methodologies.  We aim to create a registry and biorepository of tissue and fluid specimens for future studies.

2. Nasal Sinus Specimen Collection (NSSC) Project

   Rochester, Minn.

   This study is being done in order to gain a greater understanding of rhinitis and sinusitis conditions and to improve diagnostic and treatment options for these conditions.

3. A Study Identifying Blood Serum Markers of the Immune System Affecting Different Features of Chronic Rhinosinusitis

   Rochester, Minn.

   The purpose of this study is to find out what immune system processes cause the chronic inflammation that happens with chronic rhinosinusitis (CRS) and if there are different immune system pathways involved among CRS patients.

4. Participation in a Research Registry for Immune Disorders

   Rochester, Minn.

   The purpose of this study is to build a National Registry of individuals with one of the group of primary immune deficiency diseases. A "Registry" is a list of basic information about people who have a certain disease or condition in common. These immune deficiency diseases are thought to be rare and include: Severe combined immunodeficiency (SCID), leukocyte adhesion deficiency (LAD), X-linked Agammaglobulinemia (XLA), common variable immune deficiency (CVID), DiGeorge syndrome (DGS), Hyper IgM syndrome (HIGM), Wiskott Aldrich syndrome (WAS) and chronic granulomatous disease (CGD). We would like to contribute data on a number of subjects with these relatively rare diseases to this National Registry Data Base. The information will be age, sex, race or ethnic group, immunologic lab tests that were used to diagnose the condition, what complications may have occurred since the condition started, lung disease, blood changes, etc. and the results of various treatments used. The goal is to discover basic outcome data, ethnic, racial characteristics, kind of complications and useful treatments. You will not be contacted by anyone unless you authorize it. If a new study about you (or your child’s) immune defect comes up, your doctor will be notified, who can then share this with you to find out if you are interested in participating or not. Alternatively you may elect to be contacted directly by the Registry to determine your interest in participation.

5. A Study to Evaluate the Effectiveness and Tolerability of a Topical Composition Therapy for the Treatment of Cutaneous Mastocytosis

   Rochester, Minn.

   The purpose of this study is to determine the effectiveness and tolerability of a novel topical preparation for the treatment of cutaneous lesions of mastocytosis.

6. Study to Analyze the Metabolic Environment in Preventing Atopic Dermatitis

   Rochester, Minn.

   The purpose of this study is to compare the assessment of the composition of the fecal, nasal,oral and skin microbiota in patients with AD (cases) as compared to age/sex and diet matched control children without atopic dermatitis, and to apply mass-spectrometry-based metabolomic approach to analyzing fecal, nasal, oral and skin samples from cases, in order to characterize their biochemical metabolic profiles by comparison with those of their controls.

7. Mayo Clinic Drug Allergy Repository

   Jacksonville, Fla., Eau Claire, Wis., Scottsdale/Phoenix, Ariz.

   The purpose of this study is to build a Mayo Clinic registry of data and biobank from subjects with drug allergy. The data collected will include demographic, diagnostic, and health data on a large group of patients to discover novel drug allergy diagnostic methods.

8. A Study to Evaluate the Safety and Effectiveness of Lanadelumab to Prevent Acute Attacks of Non-histaminergic Angioedema

   Rochester, Minn.

   The purpose of this study is to evaluate the long-term safety and effectiveness of repeated subcutaneous (SC) administration of lanadelumab in adults with non-histaminergic angioedema with normal C1-inhibitor who completed study SHP643-303.

9. A Study of Biomarkers for the Diagnosis of Mastocytosis

   Rochester, Minn.

   The purpose of this study is to identify biomarkers that can show differences in mast cell disease (Mastocytosis) status and activity for help with diagnosis and prognosis.

10. Evaluation of Immunophenotype Signatures in Hypereosinophilia-Associated Disorders

    Rochester, Minn.

    The purpose of this study is to characterize the immunophenotype of individuals with hypereosinophilia-associated cardiovascular, gastrointestinal, hematologic, and respiratory disorders.