Publications Print Murphy SG, Ross T, Fitzgerald A, Gauthier NPG, Keller E, Barker E, Memon W, Chorlton SD, Moore T, Curless MS, Fabre V, Maragakis LL, Simner PJ, Zhang SX. Detecting healthcare-associated transmission and antifungal resistance in Candida auris via whole genome sequencing. J Clin Microbiol. 2026 Mar 25; e0134825 [Epub ahead of print] View PubMed Simner PJ. The shift from "MIC-Only" back to carbapenemase testing among carbapenem-resistant Enterobacterales: what clinical laboratories need to know about updated CLSI guidance. J Clin Microbiol. 2026 Mar 18; e0045125 [Epub ahead of print] View PubMed Kambli P, Basu S, Rodrigues S, Simner PJ, Robinson ML, Lu J, Rodrigues C. Plazomicin activity against carbapenem-resistant Escherichia coli: A brief report. Indian J Med Microbiol. 2026 Mar-Apr; 60:101078 Epub 2026 Feb 12 View PubMed Li G, Puumala E, Zhang Z, Rajapakse NS, Ristagno EH, Wolf MJ, Rodning AA, Simner PJ, Gaensbauer JT, Patel R. Cerebrospinal Fluid Metagenomic Next-Generation Sequencing in Pediatric Central Nervous System Infection: Clinical Experience and Diagnostic Stewardship Strategies. Open Forum Infect Dis. 2026 Feb; 13 (2):ofag054 Epub 2026 Feb 05 View PubMed Simner PJ, Harris H, Jacobs E, Stambaugh H, Bhalodi A, Fisher M, Tekle T, Lu J, Humphries R. Establishing Clinical and Laboratory Standards Institute M45 antimicrobial susceptibility testing methods and breakpoints for Pseudomonas other than Pseudomonas aeruginosa. J Clin Microbiol. 2025 Aug 13; 63 (8):e0036825 Epub 2025 June 30 View PubMed Buyukyanbolu E, Argotsinger J, Beck ET, Chamberland RR, Clark AE, Daniels AR, Liesman R, Fisher M, Gialanella P, Hand J, Harrington AT, Humphries RM, Huse H, Hamilton-Seth R, Hankins JD, Kufel WD, Riddell SW, Marino J, Westblade LF, Mochon AB, Narayanan N, Kirn TJ, Pierce VM, Potula R, Tekle T, Simner PJ, Tibbetts RJ, Vu C, Abbo LM, Martinez O, Dumm RE, Nicolau DP, Asempa TE, Acinetobacter baumannii Complex National Biorepository (ACNBio) Study Group. Activity of ampicillin-sulbactam, sulbactam-durlobactam, and comparators against Acinetobacter baumannii-calcoaceticus complex strains isolated from respiratory and bloodstream sources: results from ACNBio study. Antimicrob Agents Chemother. 2025 Aug 6; 69 (8):e0037925 Epub 2025 July 17 View PubMed Fissel JA, Bergman Y, Campodonico VL, Walsh DM, Fanelli B, Arogyaswamy K, Kwon JH, Milstone AM, Tamma PD, Simner PJ. Microbiome and resistome characterization of patients colonized with carbapenem-resistant Enterobacterales by long-read metagenomic next-generation sequencing of rectal swabs. JAC Antimicrob Resist. 2025 Aug; 7 (4):dlaf152 Epub 2025 Aug 28 View PubMed Kuti JL, Lutgring JD, Simner PJ, Naccache SN, Heil EL. Point-Counterpoint: Cascade reporting-useful tool to support antimicrobial stewardship, or dangerously misleading. J Clin Microbiol. 2025 Jul 9; 63 (7):e0170824 Epub 2025 June 17 View PubMed Harris H, Stambaugh H, Jacobs E, Bhalodi A, Chandrasekaran S, Cole NC, Lu J, Tekle T, Humphries R, Simner PJ. Defining antimicrobial susceptibility testing methods and breakpoints among Achromobacter species. J Clin Microbiol. 2025 Jun 11; 63 (6):e0026425 Epub 2025 Apr 30 View PubMed Rahmani S, Basu S, Simner PJ, Kambli P, Shetty A, Rodrigues C. Evaluation of the rapid lateral flow assay (LFA) for detection of five major carbapenemase enzyme families in genotypically characterised bacterial isolates. Indian J Med Res. 2025 Jun; 161 (6):695-701 View PubMed Humphries RM, Simner PJ. Major updates to FDA-recognized Clinical and Laboratory Standards Institute breakpoints are a win for the fight against antimicrobial resistance. J Clin Microbiol. 2025 May 14; 63 (5):e0010625 Epub 2025 Apr 14 View PubMed Sullivan KV, Souers RJ, Hillesland E, Pillai D, Rhoads DD, Rolf R, Simner PJ, Wojewoda CM, Rauch CA. High Prevalence of Multistep Algorithms in Diagnostic Clostridioides difficile Laboratory Testing. Arch Pathol Lab Med. 2025 May 1; 149 (5):405-409 View PubMed Fouad A, Nicolau SE, Tamma PD, Simner PJ, Nicolau DP, Gill CM. Comparison of the in vivo efficacy and resistance development potential between cefiderocol and ceftolozane/tazobactam human simulated exposures against Pseudomonas aeruginosa in 72-hour murine thigh infection model. Infect Dis (Lond). 2025 Mar 5; 1-11 Epub 2025 Mar 05 View PubMed Hareza DA, Bergman Y, Jacobs E, Lu J, Hanson ND, Conzemius R, Cosgrove SE, Harris AD, Simner PJ, Tamma PD. Molecular epidemiology of beta-lactamases in ceftriaxone-resistant Enterobacterales bloodstream infections in the mid-Atlantic United States. Antimicrob Agents Chemother. 2025 Mar 5; 69 (3):e0125824 Epub 2025 Jan 27 View PubMed Campodónico VL, Ruelle J, Fitzgerald A, Bergman Y, Osborne B, Bourdas D, Lu J, Carroll KC, Simner PJ. Evaluation of Long-read 16S rRNA Next-Generation Sequencing for Identification of Bacterial Isolates in a Clinical Diagnostic Laboratory. Clin Microbiol. 2025. Simner PJ, Lippincott C, Gudenkauf J, Salazar A, Lu J, Antenucci S, Bangs J. The Awakening of Sleeping Sickness after B-cell depleting therapy in a patient with SLE New Engl J Med.. 2025. Harris H, Stambaugh H, Jacobs E, Bhalodi A, Fisher M, Lu J, Tekle T, Humphries R, Simner PJ. Defining Clinical and Laboratory Standards Institute Antimicrobial Susceptibility Testing Breakpoints for Pseudomonas non-aeruginosa species J Clin Microbiol.. 2025. Liberman P, Light JG, Dharssi S, Howard T, Lu J, Simner PJ, Carroll KC, Ho CY. Crystalline lens dislocation as a presenting sign of Streptococcus pyogenes invasive infections. Access Microbiol. 2025; 7 (5) Epub 2025 May 27 View PubMed Maynard R, Manuel C, Simpkins S, Haro M, Ledeboer N, Simner PJ, Fisher M, Humphries R. Development of disk diffusion susceptibility test methods for Aerococcus spp. and updates to Clinical and Laboratory Standards Institute MIC breakpoints J Clin Microbiol.. 2025. Rock C, Hsu YJ, Milstone AM, Salinas AB, Maragakis L, Kwon N, Cosgrove SE, Simner PJ, Virk Z, Vorsteg AH, Klein E, Centers for Disease Control and Prevention's Prevention Epicenters and MInD Programs. Electronic evaluation of infection risk from room environment and prior room occupants: the transmission from room environment events (TREE) measure. Infect Control Hosp Epidemiol. 2024 Dec 12; 46 (2):1-4 [Epub ahead of print] View PubMed Simner PJ, Pitout JDD, Dingle TC. Laboratory detection of carbapenemases among Gram-negative organisms. Clin Microbiol Rev. 2024 Dec 10; 37 (4):e0005422 Epub 2024 Nov 15 View PubMed Fouad A, Nicolau SE, Tamma PD, Simner PJ, Nicolau DP, Gill CM. Differential frequency of persister cells in clinically derived isolates of Pseudomonas aeruginosa after exposure to cefiderocol and ceftolozane/tazobactam. J Antimicrob Chemother. 2024 Dec 2; 79 (12):3236-3242 View PubMed Hareza DA, Cosgrove SE, Bonomo RA, Dzintars K, Karaba SM, Hawes AM, Tekle T, Simner PJ, Tamma PD. Clinical outcomes and emergence of resistance of Pseudomonas aeruginosa infections treated with ceftolozane-tazobactam versus ceftazidime-avibactam. Antimicrob Agents Chemother. 2024 Oct 8; 68 (10):e0090724 Epub 2024 Sept 04 View PubMed Tao L, Dahlquist A, Harris H, Jacobs E, Wenzler E, Simner PJ, Humphries R. Multicenter evaluation of activity of aztreonam in combination with avibactam, relebactam, and vaborbactam against metallo-beta-lactamase-producing carbapenem-resistant gram-negative bacilli. Antimicrob Agents Chemother. 2024 Oct 8; 68 (10):e0069324 Epub 2024 Aug 19 View PubMed Claeys KC*, Simner PJ*, Tekle T, Harris AD, Jacobs E, Cosgrove SE, Tamma PD. How Accurate is Ceftriaxone at Predicting Susceptibility of Enterobacterales Isolates to Oral Higher Generation Cephalosporins Antimicrob Agents Chemother. 2024. Kaur P, Moon L, Srikumaran D, Salzberg SL, Lu J, Simner PJ, Soiberman US. No Evidence of Chronic Infection in a Metagenomic Sequencing Study of the Keratoconus Corneal Epithelium. J Clin Med. 2024 Jun 11; 13 (12) Epub 2024 June 11 View PubMed Fouad A, Nicolau SE, Tamma PD, Simner PJ, Nicolau DP, Gill CM. Assessing the impact of meropenem exposure on ceftolozane/tazobactam-resistance development in Pseudomonas aeruginosa using in vitro serial passage. J Antimicrob Chemother. 2024 May 2; 79 (5):1176-1181 View PubMed Rodino KG, Simner PJ. Status check: next-generation sequencing for infectious-disease diagnostics. J Clin Invest. 2024 Feb 15; 134 (4) View PubMed Fissel JA, Bergman Y, Campodonico V, Walsh DM, Fanelli B, Arogyaswamy K, Simner PJ. Microbiome and resistome characterization of patients colonized with carbapenem-resistant Enterobacterales by metagenomic next-generation sequencing of rectal swabs. JAC-Antimicrob Resist. 2024. Dumler JS, Nagy E, Pitout J, Simner PJ, Turenne C (section eds), Carroll KC, Pfaller MA (eds). Manual of Clinical Microbiology, 13th Edition. ASM Press. 2024. Campodonico VL, Hanlon A, Mikula MW, Miller JA, Gherna M, Carroll KC, Simner PJ. A diagnostic stewardship approach to prevent unnecessary testing of an enteric bacterial molecular panel. Microbiol Spectr. 2023 Dec 12; 11 (6):e0294523 Epub 2023 Oct 30 View PubMed Hogan CA, Miller S, Piantadosi A, Gaston DC, Simner PJ, Nash S, Babady NE. Which trial do we need? Plasma metagenomic next-generation sequencing to diagnose infections in patients with haematological malignancies and febrile neutropenia: proposal for a randomized-controlled trial. Clin Microbiol Infect. 2023 Dec; 29 (12):1474-1479 Epub 2023 May 25 View PubMed Pierce VM, Bhowmick T, Simner PJ. Guiding antimicrobial stewardship through thoughtful antimicrobial susceptibility testing and reporting strategies: an updated approach in 2023. J Clin Microbiol. 2023 Nov 21; 61 (11):e0007422 Epub 2023 Sept 28 View PubMed Patel JB, Alby K, Humphries R, Weinstein M, Lutgring JD, Naccache SN, Simner PJ. Updating breakpoints in the United States: a summary from the ASM Clinical Microbiology Open 2022. J Clin Microbiol. 2023 Oct 24; 61 (10):e0115422 Epub 2023 Oct 04 View PubMed Hanson KE, Banerjee R, Doernberg SB, Evans SR, Komarow L, Satlin MJ, Schwager N, Simner PJ, Tillekeratne LG, Patel R, Antibacterial Resistance Leadership Group. Priorities and Progress in Diagnostic Research by the Antibacterial Resistance Leadership Group. Clin Infect Dis. 2023 Oct 16; 77 (Suppl 4):S314-S320 View PubMed Fouad A, Gill CM, Simner PJ, Nicolau DP, Asempa TE. Cefepime in vivo activity against carbapenem-resistant Enterobacterales that test as cefepime susceptible or susceptible-dose dependent in vitro: implications for clinical microbiology laboratory and clinicians. J Antimicrob Chemother. 2023 Sep 5; 78 (9):2242-2253 View PubMed Humphries RM, Lu J, Martin I, Rauch CA, Wojewoda C, McCarter Y, Long T, Simner PJ. Detection of Penicillin Nonsusceptible Streptococcus agalactiae by Laboratories That Participate in the College of American Pathologist's Proficiency Testing Program. J Clin Microbiol.. 2023. Satlin M, Simner P, Slover C, Yamano Y, Nagata T, Portsmouth S. Cefiderocol Treatment for Patients with Multidrug- and Carbapenem-Resistant Pseudomonas aeruginosa Infections in the Compassionate Use Program Antimicrob Agents Chemother.. 2023. Campodonico V, Tekle T, Bergman Y, Lu J, Gisriel E, Romagnoli M, Bourdas D, Hanlon A, Manuel C, Humphries R, Simner PJ, and K. Clinical Significance of Nosocomiicoccus ampullae Isolated from Blood Cultures. Microbiology Spectrum.. 2023. Simner PJ, Dien Bard J, Doern C, Kristie Johnson J, Westblade L, Yenokyan G, Patel R, Hanson KE, Antibacterial Resistance Leadership Group. Reporting of Antimicrobial Resistance from Blood Cultures, an Antibacterial Resistance Leadership Group Survey Summary: Resistance Marker Reporting Practices from Positive Blood Cultures. Clin Infect Dis. 2023 May 3; 76 (9):1550-1558 View PubMed Tamma PD, Bergman Y, Jacobs EB, Lee JH, Lewis S, Cosgrove SE, Simner PJ, Centers for Disease Control and Prevention Epicenters Program. Comparing the activity of novel antibiotic agents against carbapenem-resistant Enterobacterales clinical isolates. Infect Control Hosp Epidemiol. 2023 May; 44 (5):762-767 Epub 2022 July 13 View PubMed Hareza D, Simner PJ, Bergman Y, Jacobs E, Cosgrove SE, Tamma PD. The Frequency of Extended-Spectrum-ß-Lactamase Genes Harbored by Enterobacterales Isolates at High Risk for Clinically Significant Chromosomal ampC Expression Open Forum Infect Dis.. 2023. Simner PJ, Bergman Y, Fan Y, Ramakrishnan S, Lu J, Lewis S, Hanlon A, Tamma PD, Schatz MC, Timp W, Carroll KC. Multicenter Genetic Diversity Study of Carbapenem-Resistant Enterobacterales: Predominance of Untypeable pUVA-like blaKPC Bearing Plasmids JAC-Antimicrob Resist. 2023. Weinmaier T, Conzemius R, Bergman Y, Lewis S, Jacobs E, Tamma PD, Materna A, Weinberger J, Beisken S, Simner PJ. Validation and Application of Long-read Whole Genome Sequencing for Antimicrobial Resistance Gene Detection and Antimicrobial Susceptibility Testing Antimicrob Agents Chemother. 2023. Manuel C, Maynard R, Abbott A, Adams K, Alby K, Sweeney A, Dien Bard J, Flores II, Rekasius V, Harrington A, Kidd TS, Mathers AJ, Tekle T, Simner PJ, Humphries RM. Evaluation of Piperacillin- Tazobactam Testing against Enterobacterales by the Phoenix, MicroScan, and Vitek2 Tests Using Updated Clinical and Laboratory Standards Institute Breakpoints J Clin Microbiol. 2023. Hsu A, Simner PJ, Bergman Y, Mathers AJ, Tamma PD. Successful Treatment of Persistent Stenotrophomonas maltophilia bacteremia with Cefiderocol in an Infant Open Forum Infect Dis. 2023. Martínez DA, Cai J, Lin G, Goodman KE, Paul R, Lessler J, Levin SR, Toerper M, Simner PJ, Milstone AM, Klein EY, for the CDC Prevention Epicenters Program, CDC MinD-Healthcare Program. Modeling Interventions and Contact Networks to Reduce the Spread of Carbapenem-Resistant Organisms 10 Between Individuals in the ICU Hosp Infect. 2023. Azar MM, Turbett S, Gaston D, Gitman M, Razonable R, Koo S, Hanson K, Kotton C, Silveira F, Banach DB, Basu SS, Bhaskaran A, Danziger-Isakov L, Bard JD, Gandhi R, Hanisch B, John TM, Odom John AR, Letourneau AR, Luong ML, Maron G, Miller S, Prinzi A, Schwartz I, Simner P, Kumar D, Transplant ID Diagnostics Consensus Conference Working Group. A consensus conference to define the utility of advanced infectious disease diagnostics in solid organ transplant recipients. Am J Transplant. 2022 Dec; 22 (12):3150-3169 Epub 2022 July 27 View PubMed Yee R, Simner PJ. Next-Generation Sequencing Approaches to Predicting Antimicrobial Susceptibility Testing Results. Clin Lab Med. 2022 Dec; 42 (4):557-572 View PubMed Simner PJ, Hindler JA, Bhowmick T, Das S, Johnson JK, Lubers BV, Redell MA, Stelling J, Erdman SM. What's New in Antibiograms? Updating CLSI M39 Guidance with Current Trends. J Clin Microbiol. 2022 Oct 19; 60 (10):e0221021 Epub 2022 Aug 02 View PubMed Simner PJ, Mostafa HH, Bergman Y, Ante M, Tekle T, Adebayo A, Beisken S, Dzintars K, Tamma PD. Progressive Development of Cefiderocol Resistance in Escherichia coli During Therapy is Associated With an Increase in blaNDM-5 Copy Number and Gene Expression. Clin Infect Dis. 2022 Aug 24; 75 (1):47-54 View PubMed Drewes JL, Chen J, Markham NO, Knippel RJ, Domingue JC, Tam AJ, Chan JL, Kim L, McMann M, Stevens C, Dejea CM, Tomkovich S, Michel J, White JR, Mohammad F, Campodonico VL, Heiser CN, Wu X, Wu S, Ding H, Simner P, Carroll K, Shrubsole MJ, Anders RA, Walk ST, Jobin C, Wan F, Coffey RJ, Housseau F, Lau KS, Sears CL. Human Colon Cancer-Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice. Cancer Discov. 2022 Aug 5; 12 (8):1873-1885 View PubMed Canton R, Doi Y, Simner PJ. Treatment of carbapenem-resistant Pseudomonas aeruginosa infections: a case for cefiderocol. Expert Rev Anti Infect Ther. 2022 Aug; 20 (8):1077-1094 Epub 2022 May 10 View PubMed Vornhagen J, Roberts EK, Unverdorben L, Mason S, Patel A, Crawford R, Holmes CL, Sun Y, Teodorescu A, Snitkin ES, Zhao L, Simner PJ, Tamma PD, Rao K, Kaye KS, Bachman MA. Combined comparative genomics and clinical modeling reveals plasmid-encoded genes are independently associated with Klebsiella infection. Nat Commun. 2022 Aug 1; 13 (1):4459 Epub 2022 Aug 01 View PubMed Gaston DC, Miller HB, Fissel JA, Jacobs E, Gough E, Wu J, Klein EY, Carroll KC, Simner PJ. Evaluation of Metagenomic and Targeted Next-Generation Sequencing Workflows for Detection of Respiratory Pathogens from Bronchoalveolar Lavage Fluid Specimens. J Clin Microbiol. 2022 Jul 20; 60 (7):e0052622 Epub 2022 June 13 View PubMed Simner PJ. A Clinician’s Guide to Making Sense of Metagenomics MedScape Education Infectious Disease. 2022. Ahmad Y, Gaston DC, Gray J, Zhong D, Gudenkauf B, Bourdas D, Ray SC, Simner PJ. Closing the Brief Case: The Fly Who Cried Wohlf. J Clin Microbiol. 2022 Jun 15; 60 (6):e0108121 Epub 2022 June 15 View PubMed Ahmad Y, Gaston DC, Gray J, Zhong D, Gudenkauf B, Bourdas D, Ray SC, Simner PJ. The Brief Case: The Fly Who Cried Wohlf. J Clin Microbiol. 2022 Jun 15; 60 (6):e0107321 Epub 2022 June 15 View PubMed Angkeow JW, Monaco DR, Chen A, Venkataraman T, Jayaraman S, Valencia C, Sie BM, Liechti T, Farhadi PN, Funez-dePagnier G, Sherman-Baust CA, Wong MQ, Ruczinski I, Caturegli P, Sears CL, Simner PJ, Round JL, Duggal P, Laserson U, Steiner TS, Sen R, Lloyd TE, Roederer M, Mammen AL, Longman RS, Rider LG, Larman HB. Phage display of environmental protein toxins and virulence factors reveals the prevalence, persistence, and genetics of antibody responses. Immunity. 2022 Jun 14; 55 (6):1051-1066.e4 Epub 2022 May 31 View PubMed Simner PJ, Cherian J, Suh GA, Bergman Y, Beisken S, Fackler J, Lee M, Hopkins RJ, Tamma PD. Combination of phage therapy and cefiderocol to successfully treat Pseudomonas aeruginosa cranial osteomyelitis. JAC Antimicrob Resist. 2022 Jun; 4 (3):dlac046 Epub 2022 May 05 View PubMed Gaston DC, Simner PJ. Taking the Next Step in Metagenomic Infectious Disease Diagnostics. Clin Chem. 2022 Jun 1; 68 (6):751-753 View PubMed Gordon O, Peart Akindele N, Schumacher C, Hanlon A, Simner PJ, Carroll KC, Sick-Samuels AC. Increasing Pediatric Infectious Diseases Consultation Rates for Staphylococcus aureus Bacteremia. Pediatr Qual Saf. 2022 May-Jun; 7 (3):e560 Epub 2022 June 14 View PubMed Wright WF, Yenokyan G, Simner PJ, Carroll KC, Auwaerter PG. Geographic Variation of Infectious Disease Diagnoses Among Patients With Fever of Unknown Origin: A Systematic Review and Meta-analysis. Open Forum Infect Dis. 2022 May; 9 (5):ofac151 Epub 2022 Apr 09 View PubMed Simner PJ, Musser KA, Mitchell K, Wise MG, Lewis S, Yee R, Bergman Y, Good CE, Abdelhamed AM, Li H, Laseman EM, Sahm D, Pitzer K, Quan J, Walker GT, Jacobs MR, Rhoads DD. Multicenter Evaluation of the Acuitas AMR Gene Panel for Detection of an Extended Panel of Antimicrobial Resistance Genes among Bacterial Isolates. J Clin Microbiol. 2022 Mar 16; 60 (3):e0209821 View PubMed Wright WF, Simner PJ, Carroll KC, Auwaerter PG. Progress Report: Next-Generation Sequencing, Multiplex Polymerase Chain Reaction, and Broad-Range Molecular Assays as Diagnostic Tools for Fever of Unknown Origin Investigations in Adults. Clin Infect Dis. 2022 Mar 9; 74 (5):924-932 View PubMed Simner PJ, Rauch CA, Martin IW, Sullivan KV, Rhoads D, Rolf R, She R, Souers RJ, Wojewoda C, Humphries RM. Raising the Bar: Improving Antimicrobial Resistance Detection by Clinical Laboratories by Ensuring Use of Current Breakpoints. Open Forum Infect Dis. 2022 Mar; 9 (3):ofac007 Epub 2022 Feb 07 View PubMed Price TK, Davar K, Contreras D, Ward KW, Garner OB, Simner PJ, Yang S, Chandrasekaran S. Case Report and Genomic Analysis of Cefiderocol-Resistant Escherichia coli Clinical Isolates. Am J Clin Pathol. 2022 Feb 3; 157 (2):257-265 View PubMed Simner PJ, Beisken S, Bergman Y, Ante M, Posch AE, Tamma PD. Defining Baseline Mechanisms of Cefiderocol Resistance in the Enterobacterales. Microb Drug Resist. 2022 Feb; 28 (2):161-170 Epub 2021 Oct 06 View PubMed Conzemius R, Bergman Y, Majek P, Beisken S, Lewis S, Jacobs EB, Tamma PD, Simner PJ. Automated antimicrobial susceptibility testing and antimicrobial resistance genotyping using Illumina and Oxford Nanopore Technologies sequencing data among Enterobacteriaceae. Front Microbiol. 2022; 13:973605 Epub 2022 Aug 08 View PubMed Garcia-Fernandez S, Simner PJ, Thomson G, Faron M, Bosboom R, van Griethuijsen A, Garcia-Castillo M, Harris R, Ledeboer NA, Canton R, Thomson KS. Rapid identification from rectal swabs of the clinically most relevant carbapenemase genes from gram-negative bacteria using the BD MAX Check-Points CPO Assay. Diagn Microbiol Infect Dis. 2022 Jan; 102 (1):115554 Epub 2021 Sept 25 View PubMed Farhadi PN, Funez-dePagnier G, Sherman-Baust CA, Wong MQ, Ruczinski I, Caturegli P, Sears CL, Simner PJ, Round JL, Duggal P, Laserson U, Steiner TS, Sen R, Lloyd TE, Roedere M, Mammen AL, Longman RS, Rider LG, Larman HB. Prevalence, persistence, and genetics of antibody responses to protein toxins and virulence factors Immunity. 2022. Datar R, Orenga S, Pogorelcnik R, Rochas O, Simner PJ, van Belkum A. Recent Advances in Rapid Antimicrobial Susceptibility Testing. Clin Chem. 2021 Dec 30; 68 (1):91-98 View PubMed Tamma PD, Beisken S, Bergman Y, Posch AE, Avdic E, Sharara SL, Cosgrove SE, Simner PJ. Modifiable Risk Factors for the Emergence of Ceftolozane-tazobactam Resistance. Clin Infect Dis. 2021 Dec 6; 73 (11):e4599-e4606 View PubMed Yanson K, Laviers W, Neely L, Lockamy E, Castillo-Hernandez LC, Oldfied C, Ackerman R, Ackerman J, Ortiz DA, Pacheco S, Simner PJ, Young S, McElvania E, Cooper CK. Performance Evaluation of the BD SARS-CoV-2 Reagents for the BD MAX System. J Clin Microbiol. 2021 Nov 18; 59 (12):e0101921 Epub 2021 Sept 29 View PubMed Yee R, Fisher S, Bergman Y, Chambers KK, Tamma PD, Carroll KC, Simner PJ. Combined selective culture and molecular methods for the detection of carbapenem-resistant organisms from fecal specimens. Eur J Clin Microbiol Infect Dis. 2021 Nov; 40 (11):2315-2321 Epub 2021 June 11 View PubMed Peaper DR, Rhoads DD, Sullivan KV, Couturier MR, Humphries RM, Martin IW, Nolte FS, Rowlinson MC, She RC, Simner PJ, Theel ES, Wojewoda CM. Considerations from the College of American Pathologists for Implementation of an Assay for SARS-CoV-2 Testing after a Change in Regulatory Status. J Clin Microbiol. 2021 Sep 20; 59 (10):e0116721 Epub 2021 July 14 View PubMed Castanheira M, Simner PJ, Bradford PA. Extended-spectrum beta-lactamases: an update on their characteristics, epidemiology and detection. JAC Antimicrob Resist. 2021 Sep; 3 (3):dlab092 Epub 2021 July 16 View PubMed Mc Gann P, Geringer MR, Hall LR, Lebreton F, Markelz E, Kwak YI, Johnson S, Ong AC, Powell A, Tekle T, Bergman Y, Simner PJ, Bennett JW, Cybulski RJ, White BK. Pan-drug resistant Providencia rettgeri contributing to a fatal case of COVID-19. J Med Microbiol. 2021 Aug; 70 (8) View PubMed Simner PJ, Beisken S, Bergman Y, Posch AE, Cosgrove SE, Tamma PD. Cefiderocol Activity Against Clinical Pseudomonas aeruginosa Isolates Exhibiting Ceftolozane-Tazobactam Resistance. Open Forum Infect Dis. 2021 Jul; 8 (7):ofab311 Epub 2021 June 12 View PubMed Yee R, Dien Bard J, Simner PJ. The Genotype-to-Phenotype Dilemma: How Should Laboratories Approach Discordant Susceptibility Results? J Clin Microbiol. 2021 May 19; 59 (6) View PubMed Tamma PD, Smith TT, Adebayo A, Karaba SM, Jacobs E, Wakefield T, Nguyen K, Whitfield NN, Simner PJ. Prevalence of bla(CTX-M) Genes in Gram-Negative Bloodstream Isolates across 66 Hospitals in the United States. J Clin Microbiol. 2021 May 19; 59 (6) View PubMed Vornhagen J, Bassis CM, Ramakrishnan S, Hein R, Mason S, Bergman Y, Sunshine N, Fan Y, Holmes CL, Timp W, Schatz MC, Young VB, Simner PJ, Bachman MA. A plasmid locus associated with Klebsiella clinical infections encodes a microbiome-dependent gut fitness factor. PLoS Pathog. 2021 Apr; 17 (4):e1009537 Epub 2021 Apr 30 View PubMed Ramos AP, Leonhard SE, Halstead SK, Cuba MA, Castaneda CC, Dioses JA, Tipismana MA, Abanto JT, Llanos A, Gourlay D, Grogl M, Ramos M, Rojas JD, Meza R, Puiu D, Sherman RM, Salzberg SL, Simner PJ, Willison HJ, Jacobs BC, Cornblath DR, Umeres HF, Pardo CA. Guillain-Barre Syndrome Outbreak in Peru 2019 Associated With Campylobacter jejuni Infection. Neurol Neuroimmunol Neuroinflamm. 2021 Mar; 8 (2) Epub 2021 Feb 05 View PubMed Yee R, Breitwieser FP, Hao S, Opene BNA, Workman RE, Tamma PD, Dien-Bard J, Timp W, Simner PJ. Metagenomic next-generation sequencing of rectal swabs for the surveillance of antimicrobial-resistant organisms on the Illumina Miseq and Oxford MinION platforms. Eur J Clin Microbiol Infect Dis. 2021 Jan; 40 (1):95-102 Epub 2020 Aug 11 View PubMed Yee R, Fisher S, Bergman Y, Chambers KK, Tamma PD, Carroll KC, Simner PJ. Combined Selective Culture and Molecular Methods for the Detection of Carbapenem-Resistant Organisms from Fecal Specimens: The Need for Rapid Results and Organism Recovery Eur J Clin Microbiol Infect Dis.. 2021; 2315-2321.. Simner PJ, Patel R. Cefiderocol Antimicrobial Susceptibility Testing Considerations: the Achilles' Heel of the Trojan Horse? J Clin Microbiol. 2020 Dec 17; 59 (1) View PubMed Morris CP, Bergman Y, Tekle T, Fissel JA, Tamma PD, Simner PJ. Cefiderocol Antimicrobial Susceptibility Testing against Multidrug-Resistant Gram-Negative Bacilli: a Comparison of Disk Diffusion to Broth Microdilution. J Clin Microbiol. 2020 Dec 17; 59 (1) View PubMed Mostafa HH, Fissel JA, Fanelli B, Bergman Y, Gniazdowski V, Dadlani M, Carroll KC, Colwell RR, Simner PJ. Metagenomic Next-Generation Sequencing of Nasopharyngeal Specimens Collected from Confirmed and Suspect COVID-19 Patients. mBio. 2020 Nov 20; 11 (6) View PubMed Sharara SL, Amoah J, Pana ZD, Simner PJ, Cosgrove SE, Tamma PD. Is Piperacillin-Tazobactam Effective for the Treatment of Pyelonephritis Caused by Extended-Spectrum beta-Lactamase-Producing Organisms? Clin Infect Dis. 2020 Nov 5; 71 (8):e331-e337 View PubMed Bharucha T, Oeser C, Balloux F, Brown JR, Carbo EC, Charlett A, Chiu CY, Claas ECJ, de Goffau MC, de Vries JJC, Eloit M, Hopkins S, Huggett JF, MacCannell D, Morfopoulou S, Nath A, O'Sullivan DM, Reoma LB, Shaw LP, Sidorov I, Simner PJ, Van Tan L, Thomson EC, van Dorp L, Wilson MR, Breuer J, Field N. STROBE-metagenomics: a STROBE extension statement to guide the reporting of metagenomics studies. Lancet Infect Dis. 2020 Oct; 20 (10):e251-e260 Epub 2020 Aug 05 View PubMed Jenkins S, Ledeboer NA, Westblade LF, Burnham CA, Faron ML, Bergman Y, Yee R, Mesich B, Gerstbrein D, Wallace MA, Robertson A, Fauntleroy KA, Klavins AS, Malherbe R, Hsiung A, Simner PJ. Evaluation of NG-Test Carba 5 for Rapid Phenotypic Detection and Differentiation of Five Common Carbapenemase Families: Results of a Multicenter Clinical Evaluation. J Clin Microbiol. 2020 Jun 24; 58 (7) Epub 2020 June 24 View PubMed Uhteg K, Jarrett J, Richards M, Howard C, Morehead E, Geahr M, Gluck L, Hanlon A, Ellis B, Kaur H, Simner P, Carroll KC, Mostafa HH. Comparing the analytical performance of three SARS-CoV-2 molecular diagnostic assays. J Clin Virol. 2020 Jun; 127:104384 Epub 2020 Apr 26 View PubMed Fenwick AJ, Bergman Y, Lewis S, Yee R, Uhlemann AC, Cole N, Kohner P, Ordak C, Green DA, Schuetz AN, Humphries R, Simner PJ. Evaluation of the NG-Test MCR-1 Lateral Flow Assay and EDTA-Colistin Broth Disk Elution Methods To Detect Plasmid-Mediated Colistin Resistance among Gram-Negative Bacterial Isolates. J Clin Microbiol. 2020 Mar 25; 58 (4) View PubMed Green DA, Macesic N, Uhlemann AC, Lopez M, Stump S, Whittier S, Schuetz AN, Simner PJ, Humphries RM. Evaluation of Calcium-Enhanced Media for Colistin Susceptibility Testing by Gradient Agar Diffusion and Broth Microdilution. J Clin Microbiol. 2020 Jan 28; 58 (2) View PubMed Fissel JA, Yarbrough ML, Tekle T, Burnham CAD, Simner PJ. Reporting Considerations for Cefepime Susceptible and Susceptible-Dose Dependent Results for Carbapenemase-Producing Enterobacterales J Clin Microbiol.. 2020. Workneh M, Wang R, Kazmi AQ, Chambers KK, Opene BNA, Lewis S, Goodman K, Tamma PD, Carroll KC, Milstone AM, Simner PJ. Evaluation of the Direct MacConkey Method for Identification of Carbapenem-Resistant Gram-Negative Organisms from Rectal Swabs: Reevaluating Zone Diameter Cutoffs. J Clin Microbiol. 2019 Dec; 57 (12) Epub 2019 Nov 22 View PubMed Humphries RM, Green DA, Schuetz AN, Bergman Y, Lewis S, Yee R, Stump S, Lopez M, Macesic N, Uhlemann AC, Kohner P, Cole N, Simner PJ. Multicenter Evaluation of Colistin Broth Disk Elution and Colistin Agar Test: a Report from the Clinical and Laboratory Standards Institute. J Clin Microbiol. 2019 Nov; 57 (11) Epub 2019 Oct 23 View PubMed Drewes JL, Corona A, Sanchez U, Fan Y, Hourigan SK, Weidner M, Sidhu SD, Simner PJ, Wang H, Timp W, Oliva-Hemker M, Sears CL. Transmission and clearance of potential procarcinogenic bacteria during fecal microbiota transplantation for recurrent Clostridioides difficile. JCI Insight. 2019 Oct 3; 4 (19) Epub 2019 Oct 03 View PubMed Tamma PD, Doi Y, Bonomo RA, Johnson JK, Simner PJ, Antibacterial Resistance Leadership Group. A Primer on AmpC beta-Lactamases: Necessary Knowledge for an Increasingly Multidrug-resistant World. Clin Infect Dis. 2019 Sep 27; 69 (8):1446-1455 View PubMed Stokes W, Simner PJ, Mortensen J, Oethinger M, Stellrecht K, Lockamy E, Lay T, Bouchy P, Pillai DR. Multicenter Clinical Validation of the Molecular BD Max Enteric Viral Panel for Detection of Enteric Pathogens. J Clin Microbiol. 2019 Sep; 57 (9) Epub 2019 Aug 26 View PubMed Mitchell SL, Simner PJ. Next-Generation Sequencing in Clinical Microbiology: Are We There Yet? Clin Lab Med. 2019 Sep; 39 (3):405-418 View PubMed Tamma PD, Sharara SL, Pana ZD, Amoah J, Fisher SL, Tekle T, Doi Y, Simner PJ. Molecular Epidemiology of Ceftriaxone Non-Susceptible Enterobacterales Isolates in an Academic Medical Center in the United States. Open Forum Infect Dis. 2019 Aug 11; 6 (8):ofz353 View PubMed Tamma PD, Kazmi A, Bergman Y, Goodman KE, Ekunseitan E, Amoah J, Simner PJ. The Likelihood of Developing a Carbapenem-Resistant Enterobacteriaceae Infection during a Hospital Stay. Antimicrob Agents Chemother. 2019 Aug; 63 (8) Epub 2019 July 25 View PubMed Goodman KE, Simner PJ, Klein EY, Kazmi AQ, Gadala A, Toerper MF, Levin S, Tamma PD, Rock C, Cosgrove SE, Maragakis LL, Milstone AM, CDC Prevention Epicenters Program. Predicting probability of perirectal colonization with carbapenem-resistant Enterobacteriaceae (CRE) and other carbapenem-resistant organisms (CROs) at hospital unit admission. Infect Control Hosp Epidemiol. 2019 May; 40 (5):541-550 Epub 2019 Mar 27 View PubMed Bell DT, Bergman Y, Kazmi AQ, Lewis S, Tamma PD, Simner PJ. A Novel Phenotypic Method To Screen for Plasmid-Mediated Colistin Resistance among Enterobacteriales. J Clin Microbiol. 2019 May; 57 (5) Epub 2019 Apr 26 View PubMed Tamma PD, Cosgrove SE, Avdic E, Carroll KC, Simner PJ. Reporting Extended-Spectrum beta-Lactamase Positivity May Reduce Carbapenem Overuse. Open Forum Infect Dis. 2019 Mar; 6 (3):ofz064 Epub 2019 Feb 19 View PubMed Simner PJ, Bergman Y, Trejo M, Roberts AA, Marayan R, Tekle T, Campeau S, Kazmi AQ, Bell DT, Lewis S, Tamma PD, Humphries R, Hindler JA. Two-Site Evaluation of the Colistin Broth Disk Elution Test To Determine Colistin In Vitro Activity against Gram-Negative Bacilli. J Clin Microbiol. 2019 Feb; 57 (2) Epub 2019 Jan 30 View PubMed Tamma PD, Fan Y, Bergman Y, Pertea G, Kazmi AQ, Lewis S, Carroll KC, Schatz MC, Timp W, Simner PJ. Applying Rapid Whole-Genome Sequencing To Predict Phenotypic Antimicrobial Susceptibility Testing Results among Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates. Antimicrob Agents Chemother. 2019 Jan; 63 (1) Epub 2018 Dec 21 View PubMed Workneh M, Yee R, Simner PJ. The Various Phenotypic Methods for Detection of Carbapenemase Production in Carbapenem-Resistant Organisms What Method Should You Choose Clin Microb Newsl. 2019. Goodman KE, Simner PJ, Klein EY, Kazmi AQ, Gadala A, Toerper MF, Levin S, Tamma PD, Rock C, Cosgrove SE, Maragakis LL, Milstone AM, for the CDC Prevention Epicenters Program, CDC MIND-Healthcare Program. Predicting Probability of Perirectal Colonization with Carbapenem-Resistant Organisms At Hospital Unit Admission. Infect Control Hosp Epidemiol. 2019. Goodman KE, Simner PJ, Klein EY, Kazmi AQ, Gadala A, Rock C, Tamma PD, Cosgrove SE, Maragakis LL, Milstone AM, CDC Prevention Epicenters Program. How frequently are hospitalized patients colonized with carbapenem-resistant Enterobacteriaceae (CRE) already on contact precautions for other indications? Infect Control Hosp Epidemiol. 2018 Dec; 39 (12):1491-1493 Epub 2018 Oct 01 View PubMed Brown-Elliott BA, Simmer PJ, Trovato A, Hyle EP, Droz S, Buckwalter SP, Borroni E, Branda JA, Iana E, Mariottini A, Nelson J, Matteelli A, Toney NC, Scarparo C, de Man TJB, Vasireddy R, Gandhi RT, Wengenack NL, Cirillo DM, Wallace RJ, Tortoli E. Mycobacterium decipiens sp. nov., a new species closely related to the Mycobacterium tuberculosis complex. Int J Syst Evol Microbiol. 2018 Nov; 68 (11):3557-3562 Epub 2018 Sept 11 View PubMed Tamma PD, Simner PJ. Phenotypic Detection of Carbapenemase-Producing Organisms from Clinical Isolates. J Clin Microbiol. 2018 Nov; 56 (11) Epub 2018 Oct 25 View PubMed Rock C, Anderson M, Lewis S, Scheeler V, Nowakowski E, Hsu YJ, Milstone AM, Carroll KC, Maragakis LL, Simner PJ, CDC Prevention Epicenters Program. Comparison of nylon-flocked swab and cellulose sponge methods for carbapenem-resistant Enterobacteriaceae and gram-negative organism recovery from high-touch surfaces in patient rooms. Infect Control Hosp Epidemiol. 2018 Oct; 39 (10):1257-1261 Epub 2018 Aug 28 View PubMed Simner PJ, Miller HB, Breitwieser FP, Pinilla Monsalve G, Pardo CA, Salzberg SL, Sears CL, Thomas DL, Eberhart CG, Carroll KC. Development and Optimization of Metagenomic Next-Generation Sequencing Methods for Cerebrospinal Fluid Diagnostics. J Clin Microbiol. 2018 Sep; 56 (9) Epub 2018 Aug 27 View PubMed Allison DB, Simner PJ, Ali SZ. Identification of infectious organisms in cytopathology: A review of ancillary diagnostic techniques. Cancer Cytopathol. 2018 Aug; 126 Suppl 8:643-653 View PubMed Simner PJ, Antar AAR, Hao S, Gurtowski J, Tamma PD, Rock C, Opene BNA, Tekle T, Carroll KC, Schatz MC, Timp W. Antibiotic pressure on the acquisition and loss of antibiotic resistance genes in Klebsiella pneumoniae. J Antimicrob Chemother. 2018 Jul 1; 73 (7):1796-1803 View PubMed Simner PJ, Goodman KE, Carroll KC, Harris AD, Han JH, Tamma PD. Using Patient Risk Factors to Identify Whether Carbapenem-Resistant Enterobacteriaceae Infections Are Caused by Carbapenemase-Producing Organisms. Open Forum Infect Dis. 2018 May; 5 (5):ofy094 Epub 2018 May 17 View PubMed Pancholi P, Carroll KC, Buchan BW, Chan RC, Dhiman N, Ford B, Granato PA, Harrington AT, Hernandez DR, Humphries RM, Jindra MR, Ledeboer NA, Miller SA, Mochon AB, Morgan MA, Patel R, Schreckenberger PC, Stamper PD, Simner PJ, Tucci NE, Zimmerman C, Wolk DM. Multicenter Evaluation of the Accelerate PhenoTest BC Kit for Rapid Identification and Phenotypic Antimicrobial Susceptibility Testing Using Morphokinetic Cellular Analysis. J Clin Microbiol. 2018 Apr; 56 (4) Epub 2018 Mar 26 View PubMed Tamma PD, Fan Y, Bergman Y, Sick-Samuels AC, Hsu AJ, Timp W, Simner PJ, Prokesch BC, Greenberg DE. Successful Treatment of Persistent Burkholderia cepacia Complex Bacteremia with Ceftazidime-Avibactam. Antimicrob Agents Chemother. 2018 Apr; 62 (4) Epub 2018 Mar 27 View PubMed Simner PJ, Miller S, Carroll KC. Understanding the Promises and Hurdles of Metagenomic Next-Generation Sequencing as a Diagnostic Tool for Infectious Diseases. Clin Infect Dis. 2018 Feb 10; 66 (5):778-788 View PubMed Liu J, Yu J, Chen F, Yu J, Simner P, Tamma P, Liu Y, Shen L. Emergence and establishment of KPC-2-producing ST11 Klebsiella pneumoniae in a general hospital in Shanghai, China. Eur J Clin Microbiol Infect Dis. 2018 Feb; 37 (2):293-299 Epub 2017 Dec 27 View PubMed Simner PJ, Johnson JK, Brasso WB, Anderson K, Lonsway DR, Pierce VM, Bobenchik AM, Lockett ZC, Charnot-Katsikas A, Westblade LF, Yoo BB, Jenkins SG, Limbago BM, Das S, Roe-Carpenter DE. Multicenter Evaluation of the Modified Carbapenem Inactivation Method and the Carba NP for Detection of Carbapenemase-Producing Pseudomonas aeruginosa and Acinetobacter baumannii. J Clin Microbiol. 2018 Jan; 56 (1) Epub 2017 Dec 26 View PubMed Tamma P, Fan Y, Bergman Y, Pertea G, Kazmi A, Lewis S, Carroll KC, Schatz MC, Timp W, Simner PJ. Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial Susceptibility Testing Results Antimicrob Agents Chemother.. 2018. Simner PJ, Oethinger M, Stellrecht KA, Pillai DR, Yogev R, Leblond H, Mortensen J. Multisite Evaluation of the BD Max Extended Enteric Bacterial Panel for Detection of Yersinia enterocolitica, Enterotoxigenic Escherichia coli, Vibrio, and Plesiomonas shigelloides from Stool Specimens. J Clin Microbiol. 2017 Nov; 55 (11):3258-3266 Epub 2017 Sept 06 View PubMed Rock C, Curless MS, Cantara M, Mehta S, Marrone KA, Carroll KC, Simner P, Maragakis LL. Resolution of Carbapenemase-Producing Klebsiella pneumoniae Outbreak in a Tertiary Cancer Center; the Role of Active Surveillance. Infect Control Hosp Epidemiol. 2017 Sep; 38 (9):1117-1119 Epub 2017 July 11 View PubMed Simner PJ, Opene BNA, Chambers KK, Naumann ME, Carroll KC, Tamma PD. Carbapenemase Detection among Carbapenem-Resistant Glucose-Nonfermenting Gram-Negative Bacilli. J Clin Microbiol. 2017 Sep; 55 (9):2858-2864 Epub 2017 July 12 View PubMed Pierce VM, Simner PJ, Lonsway DR, Roe-Carpenter DE, Johnson JK, Brasso WB, Bobenchik AM, Lockett ZC, Charnot-Katsikas A, Ferraro MJ, Thomson RB Jr, Jenkins SG, Limbago BM, Das S. Modified Carbapenem Inactivation Method for Phenotypic Detection of Carbapenemase Production among Enterobacteriaceae. J Clin Microbiol. 2017 Aug; 55 (8):2321-2333 Epub 2017 Apr 05 View PubMed Tamma PD, Opene BN, Gluck A, Chambers KK, Carroll KC, Simner PJ. Comparison of 11 Phenotypic Assays for Accurate Detection of Carbapenemase-Producing Enterobacteriaceae. J Clin Microbiol. 2017 Apr; 55 (4):1046-1055 Epub 2017 Jan 11 View PubMed Tamma PD, Goodman KE, Harris AD, Tekle T, Roberts A, Taiwo A, Simner PJ. Comparing the Outcomes of Patients With Carbapenemase-Producing and Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae Bacteremia. Clin Infect Dis. 2017 Feb 1; 64 (3):257-264 Epub 2016 Nov 09 View PubMed Simner PJ. Medical Parasitology Taxonomy Update: January 2012 to December 2015. J Clin Microbiol. 2017 Jan; 55 (1):43-47 Epub 2016 Dec 28 View PubMed Workneh M, Wang F, Romagnoli M, Simner PJ, Carroll K. Bypass graft infection and bacteremia caused by Anaerostipes caccae: First report of human infection caused by a recently described gut anaerobe. Anaerobe. 2016 Dec; 42:98-100 Epub 2016 Sept 28 View PubMed Tamma PD, Huang Y, Opene BN, Simner PJ. Determining the Optimal Carbapenem MIC That Distinguishes Carbapenemase-Producing and Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2016 Oct; 60 (10):6425-9 Epub 2016 Sept 23 View PubMed Tamma PD, Suwantarat N, Rudin SD, Logan LK, Simner PJ, Rojas LJ, Mojica MF, Carroll KC, Bonomo RA. First Report of a Verona Integron-Encoded Metallo-beta-Lactamase-Producing Klebsiella pneumoniae Infection in a Child in the United States. J Pediatric Infect Dis Soc. 2016 Sep; 5 (3):e24-7 Epub 2016 May 04 View PubMed Simner PJ, Woods GL, Wengenack NL. Mycobacteria. Microbiol Spectr. 2016 Aug; 4 (4) View PubMed Gniadek TJ, Carroll KC, Simner PJ. Carbapenem-Resistant Non-Glucose-Fermenting Gram-Negative Bacilli: the Missing Piece to the Puzzle. J Clin Microbiol. 2016 Jul; 54 (7):1700-1710 Epub 2016 Feb 24 View PubMed Simner PJ, Martin I, Opene B, Tamma PD, Carroll KC, Milstone AM. Evaluation of Multiple Methods for Detection of Gastrointestinal Colonization of Carbapenem-Resistant Organisms from Rectal Swabs. J Clin Microbiol. 2016 Jun; 54 (6):1664-1667 Epub 2016 Apr 06 View PubMed Suwantarat N, Logan LK, Carroll KC, Bonomo RA, Simner PJ, Rudin SD, Milstone AM, Tekle T, Ross T, Tamma PD. The Prevalence and Molecular Epidemiology of Multidrug-Resistant Enterobacteriaceae Colonization in a Pediatric Intensive Care Unit. Infect Control Hosp Epidemiol. 2016 May; 37 (5):535-43 Epub 2016 Feb 09 View PubMed Simner PJ, Doerr KA, Steinmetz LK, Wengenack NL. Mycobacterium and Aerobic Actinomycete Culture: Are Two Medium Types and Extended Incubation Times Necessary? J Clin Microbiol. 2016 Apr; 54 (4):1089-93 Epub 2016 Feb 10 View PubMed Goodman KE, Simner PJ, Tamma PD, Milstone AM. Infection control implications of heterogeneous resistance mechanisms in carbapenem-resistant Enterobacteriaceae (CRE). Expert Rev Anti Infect Ther. 2016; 14 (1):95-108 Epub 2015 Nov 04 View PubMed Simner PJ, Adam H, Baxter M, McCracken M, Golding G, Karlowsky JA, Nichol K, Lagace-Wiens P, Gilmour MW, Hoban DJ, Zhanel GG, Canadian Antimicrobial Resistance Alliance (CARA). Epidemiology of vancomycin-resistant enterococci in Canadian hospitals (CANWARD study, 2007 to 2013). Antimicrob Agents Chemother. 2015 Jul; 59 (7):4315-7 Epub 2015 Apr 20 View PubMed Walkty A, Gilmour M, Simner P, Embil JM, Boyd D, Mulvey M, Karlowsky J. Isolation of multiple carbapenemase-producing Gram-negative bacilli from a patient recently hospitalized in Nigeria. Diagn Microbiol Infect Dis. 2015 Apr; 81 (4):296-8 Epub 2015 Jan 19 View PubMed Simner PJ, Gilmour MW, DeGagne P, Nichol K, Karlowsky JA. Evaluation of five chromogenic agar media and the Rosco Rapid Carb screen kit for detection and confirmation of carbapenemase production in Gram-negative bacilli. J Clin Microbiol. 2015 Jan; 53 (1):105-12 Epub 2014 Oct 29 View PubMed Simner PJ, Hyle EP, Buckwalter SP, Branda JA, Brown-Elliott BA, Franklin J, Toney NC, de Man TJ, Wallace RJ Jr, Vasireddy R, Gandhi RT, Wengenack NL. Tenosynovitis caused by a novel nontuberculous Mycobacterium species initially misidentified as a member of the Mycobacterium tuberculosis complex. J Clin Microbiol. 2014 Dec; 52 (12):4414-8 Epub 2014 Sept 24 View PubMed Beam E, Vasoo S, Simner PJ, Rizzo M, Mason EL, Walker RC, Deml SM, Brown-Elliott BA, Wallace RJ Jr, Wengenack NL, Sia IG. Mycobacterium arupense flexor tenosynovitis: case report and review of antimicrobial susceptibility profiles for 40 clinical isolates. J Clin Microbiol. 2014 Jul; 52 (7):2706-8 Epub 2014 Apr 30 View PubMed Simner PJ, Buckwalter SP, Uhl JR, Wengenack NL, Pritt BS. Detection and identification of yeasts from formalin-fixed, paraffin-embedded tissue by use of PCR-electrospray ionization mass spectrometry. J Clin Microbiol. 2013 Nov; 51 (11):3731-4 Epub 2013 Aug 28 View PubMed Simner PJ, Buckwalter SP, Uhl JR, Wengenack NL. Identification of Mycobacterium species and Mycobacterium tuberculosis complex resistance determinants by use of PCR-electrospray ionization mass spectrometry. J Clin Microbiol. 2013 Nov; 51 (11):3492-8 Epub 2013 Aug 14 View PubMed Vasoo S, Cunningham SA, Kohner PC, Simner PJ, Mandrekar JN, Lolans K, Hayden MK, Patel R. Comparison of a novel, rapid chromogenic biochemical assay, the Carba NP test, with the modified Hodge test for detection of carbapenemase-producing Gram-negative bacilli. J Clin Microbiol. 2013 Sep; 51 (9):3097-101 Epub 2013 July 03 View PubMed Simner PJ, Uhl JR, Hall L, Weber MM, Walchak RC, Buckwalter S, Wengenack NL. Broad-range direct detection and identification of fungi by use of the PLEX-ID PCR-electrospray ionization mass spectrometry (ESI-MS) system. J Clin Microbiol. 2013 Jun; 51 (6):1699-706 Epub 2013 Mar 20 View PubMed Denisuik AJ, Lagace-Wiens PR, Pitout JD, Mulvey MR, Simner PJ, Tailor F, Karlowsky JA, Hoban DJ, Adam HJ, Zhanel GG, Canadian Antimicrobial Resistance Alliance. Molecular epidemiology of extended-spectrum beta-lactamase-, AmpC beta-lactamase- and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae isolated from Canadian hospitals over a 5 year period: CANWARD 2007-11. J Antimicrob Chemother. 2013 May; 68 Suppl 1:i57-65. View PubMed Simner PJ, Wengenack NL. A Fastidious Acid-Fast Bacilli ASCP Case Reports. 2013. Alfa MJ, Olson N, Degagne P, Simner PJ. Development and validation of rapid use scope test strips to determine the efficacy of manual cleaning for flexible endoscope channels. Am J Infect Control. 2012 Nov; 40 (9):860-5 Epub 2012 Feb 07 View PubMed Baudry-Simner PJ, Singh A, Karlowsky JA, Hoban DJ, Zhanel GG, Canadian Antimicrobial Resistance Alliance. Mechanisms of reduced susceptibility to ciprofloxacin in Escherichia coli isolates from Canadian hospitals. Can J Infect Dis Med Microbiol. 2012 Fall; 23 (3):e60-4 View PubMed Karlowsky JA, Lagace-Wiens PR, Simner PJ, DeCorby MR, Adam HJ, Walkty A, Hoban DJ, Zhanel GG. Antimicrobial resistance in urinary tract pathogens in Canada from 2007 to 2009: CANWARD surveillance study. Antimicrob Agents Chemother. 2011 Jul; 55 (7):3169-75 Epub 2011 May 02 View PubMed Lagacé-Wiens PRS, Tailor F, Simner P, DeCorby M, Karlowsky JA, Walkty A, Hoban DK, Zhanel GG. Activity of NXL104 in Combination with Beta-Lactams against Genetically Characterized Escherichia coli and Klebsiella pneumoniae isolates producing Class A Extended-Spectrum ß-lactamases and Class C ß- Lactamases. Antimicrob Agents Chemother. 2011. Lagace-Wiens PR, Simner PJ, Forward KR, Tailor F, Adam HJ, Decorby M, Karlowsky J, Hoban DJ, Zhanel GG, Canadian Antimicrobial Resistance Alliance (CARA). Analysis of 3789 in- and outpatient Escherichia coli isolates from across Canada--results of the CANWARD 2007-2009 study. Diagn Microbiol Infect Dis. 2011 Mar; 69 (3):314-9 View PubMed Simner PJ, Zhanel GG, Pitout J, Tailor F, McCracken M, Mulvey MR, Lagace-Wiens PR, Adam HJ, Hoban DJ, Canadian Antimicrobial Resistance Alliance (CARA). Prevalence and characterization of extended-spectrum beta-lactamase- and AmpC beta-lactamase-producing Escherichia coli: results of the CANWARD 2007-2009 study. Diagn Microbiol Infect Dis. 2011 Mar; 69 (3):326-34 View PubMed Zhanel GG, DeCorby M, Adam H, Mulvey MR, McCracken M, Lagace-Wiens P, Nichol KA, Wierzbowski A, Baudry PJ, Tailor F, Karlowsky JA, Walkty A, Schweizer F, Johnson J, Hoban DJ, Canadian Antimicrobial Resistance Alliance. Prevalence of antimicrobial-resistant pathogens in Canadian hospitals: results of the Canadian Ward Surveillance Study (CANWARD 2008). Antimicrob Agents Chemother. 2010 Nov; 54 (11):4684-93 Epub 2010 Aug 30 View PubMed Mataseje LF, Baudry PJ, Zhanel GG, Morck DW, Read RR, Louie M, Mulvey MR. Comparison of CMY-2 plasmids isolated from human, animal, and environmental Escherichia coli and Salmonella spp. from Canada. Diagn Microbiol Infect Dis. 2010 Aug; 67 (4):387-91 View PubMed Lagace-Wiens PR, Baudry PJ, Pang P, Hammond G. First description of an extended-spectrum-beta-lactamase-producing multidrug-resistant Escherichia fergusonii strain in a patient with cystitis. J Clin Microbiol. 2010 Jun; 48 (6):2301-2 Epub 2010 Apr 21 View PubMed Baudry PJ, Mataseje L, Zhanel GG, Hoban DJ, Mulvey MR. Characterization of plasmids encoding CMY-2 AmpC beta-lactamases from Escherichia coli in Canadian intensive care units. Diagn Microbiol Infect Dis. 2009 Dec; 65 (4):379-83 Epub 2009 Sept 23 View PubMed Zhanel GG, Baudry PJ, Tailor F, Cox L, Hoban DJ, Karlowsky JA. Determination of the pharmacodynamic activity of clinically achievable tigecycline serum concentrations against clinical isolates of Escherichia coli with extended-spectrum beta-lactamases, AmpC beta-lactamases and reduced susceptibility to carbapenems using an in vitro model. J Antimicrob Chemother. 2009 Oct; 64 (4):824-8 Epub 2009 July 29 View PubMed Mataseje LF, Neumann N, Crago B, Baudry P, Zhanel GG, Louie M, Mulvey MR, ARO Water Study Group. Characterization of cefoxitin-resistant Escherichia coli isolates from recreational beaches and private drinking water in Canada between 2004 and 2006. Antimicrob Agents Chemother. 2009 Jul; 53 (7):3126-30 Epub 2009 Apr 27 View PubMed Baudry PJ, Nichol K, DeCorby M, Lagace-Wiens P, Olivier E, Boyd D, Mulvey MR, Hoban DJ, Zhanel GG. Mechanisms of resistance and mobility among multidrug-resistant CTX-M-producing Escherichia coli from Canadian intensive care units: the 1st report of QepA in North America. Diagn Microbiol Infect Dis. 2009 Mar; 63 (3):319-26 View PubMed Lagace-Wiens PR, Decorby MR, Baudry PJ, Hoban DJ, Karlowsky JA, Zhanel GG, CAN-ICU study group. Differences in antimicrobial susceptibility in Escherichia coli from Canadian intensive care units based on regional and demographic variables. Can J Infect Dis Med Microbiol. 2008 Jul; 19 (4):282-6 View PubMed Zhanel GG, DeCorby MN, Nichol K, Wierzbowski A, Baudry P, Karlowsky JA, Lagacé-Wiens P, Walkty A, Mulvey MR, Hoban DJ. Antimicrobial susceptibility of 3931 organisms isolated from intensive care units in Canada Results of the Canadian National Intensive Care Unit (CAN-ICU) Study, 2005/2006. Diagn Microb Infect Dis.. 2008. Zhanel GG, Baudry P, Vashisht V, Laing N, Noreddin AM, Hoban DJ. Pharmacodynamic activity of ertapenem versus multidrug-resistant genotypically characterized extended-spectrum ß-lactamase-producing Escherichia coli using an in vitro model. Antimicrob Agents Chemother. 2008. Zhanel GG, Decorby M, Nichol KA, Baudry PJ, Karlowsky JA, Lagace-Wiens PR, McCracken M, Mulvey MR, Hoban DJ. Characterization of methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci and extended-spectrum beta-lactamase-producing Escherichia coli in intensive care units in Canada: Results of the Canadian National Intensive Care Unit (CAN-ICU) study (2005-2006). Can J Infect Dis Med Microbiol. 2008 May; 19 (3):243-9 View PubMed Baudry PJ, Nichol K, DeCorby M, Mataseje L, Mulvey MR, Hoban DJ, Zhanel GG. Comparison of antimicrobial resistance profiles among extended-spectrum-beta-lactamase-producing and acquired AmpC beta-lactamase-producing Escherichia coli isolates from Canadian intensive care units. Antimicrob Agents Chemother. 2008 May; 52 (5):1846-9 Epub 2008 Feb 25 View PubMed Zhanel GG, DeCorby M, Laing N, Weshnoweski B, Vashisht R, Tailor F, Nichol KA, Wierzbowski A, Baudry PJ, Karlowsky JA, Lagace-Wiens P, Walkty A, McCracken M, Mulvey MR, Johnson J, Hoban DJ, Canadian Antimicrobial Resistance Alliance (CARA). Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. Antimicrob Agents Chemother. 2008 Apr; 52 (4):1430-7 Epub 2008 Feb 19 View PubMed Adam HJ, Schurek KN, Nichol KA, Hoban CJ, Baudry TJ, Laing NM, Hoban DJ, Zhanel GG. Molecular characterization of increasing fluoroquinolone resistance in Streptococcus pneumoniae isolates in Canada, 1997 to 2005. Antimicrob Agents Chemother. 2007 Jan; 51 (1):198-207 Epub 2006 Nov 06 View PubMed PST-20579910 Home Publications