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B. Mark Keegan, M.D.

  1. Neurologist



  1. Rochester, Minnesota




Dr. Keegan trained in Neurology at the University of Saskatchewan in Saskatoon, Canada. He then completed two years subspecialty fellowship in Neuroimmunology and Multiple Sclerosis at Mayo Clinic in Rochester Minnesota. He joined the faculty of the Mayo Clinic in 2001 where he is a Consultant, Professor of Neurology and Head of the Division of Multiple Sclerosis and Autoimmune Neurology.

He is a clinician and performs clinically-based and translational research including clinical presentations of MS and its mimickers, paraneoplastic myelopathies, progressive MS and the use of plasma exchange for severe multiple sclerosis attacks. His research is published in high quality journals including Lancet, Brain, Neurology, Annals of Neurology and JAMA Neurology.

Relevant publications include defining progressive solitary sclerosis, and "paucisclerotic" MS showing that severe MS progression may occur from a single definable MS plaque, defining clinical factors that are associated with improved patient response to plasma exchange including the first study to clearly show a difference in patient response to MS therapy based on pathological subtype. He defined a unique inflammatory CNS disease syndrome that he named Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids or "CLIPPERS" and leads an international consortium aimed at elucidating its etiology and optimal treatments.

He is the principal investigator for Mayo Clinic on a number of multi-center therapeutic clinical trials in MS. He was the founding section editor of the Clinical Pathological Cases for the journal Neurology, a chief Editor of eMedicine and he is on the Editorial board of MS and Related Disorders. His book Common Pitfalls in Multiple Sclerosis and CNS Demyelinating Diseases was recently published by Cambridge University Press.

  • Demyelinating diseases
  • Multiple sclerosis
  1. 2001
    ResidentNeuro-immunology, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  2. 2001
    Fellow - NeuroimmunologyMayo Clinic in Rochester
  3. 1999
    Resident - Chief Neurology ResidentDivision of Neurology, University of Saskatchewan
  4. 1998
    Resident - NeurologyDivision of Neurology, University of Saskatchewan
  5. 1994
    MDMedical School, University of Saskatchewan
  6. 1990
    BA - PsychologyCollege of Arts and Sciences, University of Saskatchewan


  1. 2001
    NeurologyAmerican Board of Psychiatry and Neurology
  2. 1999
    NeurologyRoyal College of Physicians & Surgeons of Canada

Awards and honors

  1. 2011
    Top Educator Residency ProgramDepartment of Internal Medicine
  2. 2009
    Top EducatorDepartment of Internal Medicine
  3. 2008
    Top EducatorInternal Medicine Residency Program, Department of Internal Medicine
  4. 2003
    Young Investigator Congress GrantEuropean Committtee for Treatment and Research in Multiple Sclerosis (ECTRIMS)
  5. 2001
    Excellence in Teaching RecognitionMayo Medical School, Mayo Clinic College of Medicine and Science, Department of Education Administration
  6. 1994
    Graduated with DistinctionCollege of Medicine, University of Saskatchewan
  7. 1992
    Fisons Award in Immunology and AllergyAwarding Organization
  8. 1990
    Magna Cum LaudeCollege of Arts and Sciences, University of Saskatchewan

Professional memberships

  1. 2018 - present
    FellowAmerican Academy of Neurology
  2. 2016 - present
    Breakthroughs in Neurology Conference Work GroupAmerican Academy of Neurology
  3. 2015 - 2017
    MemberPractice Committee, American Academy of Neurology
  4. 2015 - present
    Advisory Council MemberAmericas Committee for Treatment & Research in Multiple Sclerosis (ACTRIMS)
  5. 2012 - present
    Associate Chair for Clinical PracticeNeurology Practice Committee, Department of Neurology
  6. 2012 - present
    MemberAmerican Neurological Association
  7. 2012 - present
    FellowAmerican Neurological Association
  8. 2011
    Invited Expert ReviewerendMS Research and Training Network Grant, Multiple Sclerosis Society of Canada
  9. 2011 - present
    MemberNeurology Executive Committee, Department of Neurology
  10. 2010 - present
    MemberSection of Multiple Sclerosis, American Academy of Neurology
  11. 2009 - present
    Division Chair MS and Autoimmune NeurologyDepartment of Neurology
  12. 2009 - present
    MemberDepartment of Neurology
  13. 2009 - 2012
    Assistant Clinical Practice ChairNeurology Practice Committee, Department of Neurology
  14. 2009 - present
    MemberNeurology Practice Committee, Department of Neurology
  15. 2009 - present
    MemberQuality Subcommittee, Department of Neurology
  16. 2009 - present
    MemberDoctors Mayo Society, Mayo Clinic Alumni Association, Mayo Clinic College of Medicine and Science
  17. 2008 - present
    MemberAsk Mayo Expert Advisory Group, Education Technology Center, Department of Education Administration
  18. 2006 - 2011
    DirectorNeurology Conferences, Department of Neurology
  19. 2005 - 2010
    MemberEducation Committee, Department of Neurology
  20. 2005 - 2010
    MemberResident Education Committee, Department of Neurology
  21. 2003 - 2008
    MemberSpinal Cord Injury Interdisciplinary Committee, Mayo Clinic Rochester Committees
  22. 1999 - present
    MemberAmerican Medical Association
  23. 1999 - present
    MemberMinnesota Medical Association
  24. 1996 - present
    MemberAmerican Academy of Neurology
    MemberContributor, Mayo Clinic Family Health Book, Office of Intellectual Property (formerly Mayo Medical Ventures)


Research activities

See a description of research activities.