Leslie J. Donato, Ph.D.

Publications

  1. Vijayvargiya P, Izundegui DG, Calderon G, Tawfic S, Batbold S, Saifuddin H, Duggan P, Melo V, Thomas T, Heeney M, Beyde A, Miller J Jr, Valles K, Oyemade K, Brant JF, Atieh J, Donato LJ, Camilleri M. Correction to: Increased Fecal Bile Acid Excretion in a Significant Subset of Patients with Other Inflammatory Diarrheal Diseases. Dig Dis Sci. 2022 Jul; 67 (7):3472
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  2. Ramos P, Jenkins SM, Donato LJ, Hartman SJ, Saenger A, Baumann NA, Block DR, Jaffe AS, Meeusen JW. The Biological Variability of Plasma Ceramides in Healthy Subjects. J Appl Lab Med. 2022 Jun 30; 7 (4):863-870
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  3. Vijayvargiya P, Gonzalez Izundegui D, Calderon G, Tawfic S, Batbold S, Saifuddin H, Duggan P, Melo V, Thomas T, Heeney M, Beyde A, Miller J Jr, Valles K, Oyemade K, Brant JF, Atieh J, Donato LJ, Camilleri M. Increased Fecal Bile Acid Excretion in a Significant Subset of Patients with Other Inflammatory Diarrheal Diseases. Dig Dis Sci. 2022 Jun; 67 (6):2413-2419 Epub 2021 Apr 22
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  4. Zheng W, Chilazi M, Park J, Sathiyakumar V, Donato LJ, Meeusen JW, Lazo M, Guallar E, Kulkarni KR, Jaffe AS, Santos RD, Toth PP, Jones SR, Martin SS. Assessing the Accuracy of Estimated Lipoprotein(a) Cholesterol and Lipoprotein(a)-Free Low-Density Lipoprotein Cholesterol. J Am Heart Assoc. 2022 Jan 18; 11 (2):e023136 Epub 2022 Jan 13
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  5. Sampson M, Ballout RA, Soffer D, Wolska A, Wilson S, Meeusen J, Donato LJ, Fatica E, Otvos JD, Brinton EA, Rosenson RS, Wilson P, Amar M, Shamburek R, Karathanasis SK, Remaley AT. A new phenotypic classification system for dyslipidemias based on the standard lipid panel. Lipids Health Dis. 2021 Nov 27; 20 (1):170
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  6. Katzman BM, Wockenfus AM, Kelley BR, Karon BS, Donato LJ. Evaluation of the Visby medical COVID-19 point of care nucleic acid amplification test. Clin Biochem. 2021 Nov 17 [Epub ahead of print]
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  7. Donato LJ, Wockenfus AM, Katzman BM, Baumann NA, Jaffe AS, Karon BS. Analytical and Clinical Considerations in Implementing the Roche Elecsys Troponin T Gen 5 STAT Assay. Am J Clin Pathol. 2021 Nov 8; 156 (6):1121-1129
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  8. Karon BS, Donato LJ, Bridgeman AR, Blommel JH, Kipp B, Maus A, Renuse S, Kemp J, Madugundu AK, Vanderboom PM, Chavan S, Dasari S, Singh RJ, Grebe SK, Pandey A. Analytical Sensitivity and Specificity of Four Point of Care Rapid Antigen Diagnostic Tests for SARS-CoV-2 Using Real-Time Quantitative PCR, Quantitative Droplet Digital PCR, and a Mass Spectrometric Antigen Assay as Comparator Methods. Clin Chem. 2021 Nov 1; 67 (11):1545-1553
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  9. Sharain K, Vasile VC, Sandoval Y, Donato LJ, Clements CM, Newman JS, Karon BS, Jaffe AS. The Elevated High-Sensitivity Cardiac Troponin T Pilot: Diagnoses and Outcomes. Mayo Clin Proc. 2021 Sep; 96 (9):2366-2375 Epub 2021 May 13
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  10. Donato LJ, Theel ES, Baumann NA, Bridgeman AR, Blommel JH, Wu Y, Karon BS. Evaluation of the genalyte maverick SARS-CoV-2 multi-antigen serology panel. J Clin Virol Plus. 2021 Sep; 1 (3):100030 Epub 2021 June 19
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  11. Katzman BM, Hain EA, Donato LJ, Baumann NA. Validation of a Commercial Reagent for the Depletion of Biotin from Serum/Plasma: A Rapid and Simple Tool to Detect Biotin Interference with Immunoassay Testing. J Appl Lab Med. 2021 Jul 7; 6 (4):992-997
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  12. Beinvogl BC, Manini ML, Camilleri M, Donato LJ, Harmsen WS, Absah I, Burch E, Schechter NL, Nurko S. Markers of Bile Acid Metabolism in Pediatric Diarrhea Predominant Irritable Bowel Syndrome and Healthy Controls. J Pediatr Gastroenterol Nutr. 2021 Jun 1; 72 (6):859-865
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  13. Donato LJ, Trivedi VA, Stransky AM, Misra A, Pritt BS, Binnicker MJ, Karon BS. Evaluation of the Cue Health point-of-care COVID-19 (SARS-CoV-2 nucleic acid amplification) test at a community drive through collection center. Diagn Microbiol Infect Dis. 2021 May; 100 (1):115307 Epub 2021 Jan 06
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  14. Vasile VC, Meeusen JW, Medina Inojosa JR, Donato LJ, Scott CG, Hyun MS, Vinciguerra M, Rodeheffer RR, Lopez-Jimenez F, Jaffe AS. Ceramide Scores Predict Cardiovascular Risk in the Community. Arterioscler Thromb Vasc Biol. 2021 Apr; 41 (4):1558-1569 Epub 2021 Feb 18
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  15. Fatica EM, Meeusen JW, Vasile VC, Jaffe AS, Donato LJ. Corrigendum to "Measuring the contribution of Lp(a) cholesterol towards LDL-C interpretation" [Clin. Biochem. 86 (2020) 45-51]. Clin Biochem. 2021 Feb; 88:56-57 Epub 2021 Jan 19
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  16. Gonzales KM, Donato LJ, Shah P, Simha V. Measurement of apolipoprotein B levels helps in the identification of patients at risk for hypertriglyceridemic pancreatitis. J Clin Lipidol. 2021 Jan-Feb; 15 (1):97-103 Epub 2020 Dec 04
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  17. Vijayvargiya P, Camilleri M, Carlson P, Nair A, Nord SL, Ryks M, Rhoten D, Burton D, Busciglio I, Lueke A, Harmsen WS, Donato LJ. Effects of Colesevelam on Bowel Symptoms, Biomarkers, and Colonic Mucosal Gene Expression in Patients With Bile Acid Diarrhea in a Randomized Trial. Clin Gastroenterol Hepatol. 2020 Dec; 18 (13):2962-2970.e6 Epub 2020 Feb 21
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  18. Fatica EM, Meeusen JW, Vasile VC, Jaffe AS, Donato LJ. Measuring the contribution of Lp(a) cholesterol towards LDL-C interpretation. Clin Biochem. 2020 Dec; 86:45-51 Epub 2020 Sept 28
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  19. Meeusen JW, Donato LJ, Kopecky SL, Vasile VC, Jaffe AS, Laaksonen R. Ceramides improve atherosclerotic cardiovascular disease risk assessment beyond standard risk factors. Clin Chim Acta. 2020 Dec; 511:138-142 Epub 2020 Oct 12
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  20. Vijayvargiya P, Camilleri M, Taylor A, Busciglio I, Loftus EV Jr, Donato LJ. Combined Fasting Serum C4 and Primary Bile Acids From a Single Stool Sample to Diagnose Bile Acid Diarrhea. Gastroenterology. 2020 Nov; 159 (5):1952-1954.e2 Epub 2020 July 06
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  21. Li L, Weiss HL, Li J, Chen Z, Donato L, Evers BM. High plasma levels of pro-NT are associated with increased colon cancer risk. Endocr Relat Cancer. 2020 Nov; 27 (11):641-646
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  22. Hilvo M, Vasile VC, Donato LJ, Hurme R, Laaksonen R. Ceramides and Ceramide Scores: Clinical Applications for Cardiometabolic Risk Stratification. Front Endocrinol (Lausanne). 2020; 11:570628 Epub 2020 Sept 29
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  23. Vijayvargiya P, Gonsalves W, Burton D, Hogan WJ, Miceli T, Rossini W, Taylor A, Lueke A, Donato L, Camilleri M. Increased fecal primary bile acids in multiple myeloma with engraftment syndrome diarrhea after stem cell transplant. Bone Marrow Transplant. 2019 Nov; 54 (11):1898-1907 Epub 2019 May 31
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  24. Donato LJ. Commentary. Clin Chem 2019 Oct; 65 (10):1219
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  25. Summerfield DD, Hartung KJ, Wiese CR, Wockenfus AM, Katzman BM, Donato LJ, Karon BS. Relationship between free hemoglobin (hemolysis), potassium and ionized calcium in lithium heparin blood gas samples collected intraoperatively. Clin Biochem. 2019 Aug; 70:46-48 Epub 2019 May 03
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  26. Vijayvargiya P, Camilleri M, Chedid V, Carlson P, Busciglio I, Burton D, Donato LJ. Analysis of Fecal Primary Bile Acids Detects Increased Stool Weight and Colonic Transit in Patients With Chronic Functional Diarrhea. Clin Gastroenterol Hepatol. 2019 Apr; 17 (5):922-929.e2 Epub 2018 June 12
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  27. Vijayvargiya P, Camilleri M, Burton D, Busciglio I, Lueke A, Donato LJ. Bile and fat excretion are biomarkers of clinically significant diarrhoea and constipation in irritable bowel syndrome. Aliment Pharmacol Ther. 2019 Mar; 49 (6):744-758 Epub 2019 Feb 10
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  28. Donato LJ, Myhre NK, Murray MA, McDonah MR, Myers JF, Maxson JA, Meek AM, Espy MJ, Furst JW, Karon BS, Binnicker MJ. Assessment of Test Performance and Potential for Environmental Contamination Associated with a Point-of-Care Molecular Assay for Group A Streptococcus in an End User Setting. J Clin Microbiol. 2019 Feb; 57 (2) Epub 2019 Jan 30
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  29. Donato LJ. LIMA1: A Newly Identified Player in the Field of Cholesterol Control. Clin Chem 2018 Dec 1; 64 (12):1792-1793
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  30. Katzman BM, Lueke AJ, Donato LJ, Jaffe AS, Baumann NA. Prevalence of biotin supplement usage in outpatients and plasma biotin concentrations in patients presenting to the emergency department. Clin Biochem. 2018 Sep; 60:11-16 Epub 2018 July 21
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  31. Meeusen JW, Donato LJ, Bryant SC, Baudhuin LM, Berger PB, Jaffe AS. Plasma Ceramides. Arterioscler Thromb Vasc Biol. 2018 Aug; 38 (8):1933-1939
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  32. Donato LJ, Meeusen JW, Lieske JC, Bergmann D, Sparwasser A, Jaffe AS. Analytical performance of an immunoassay to measure proenkephalin. Clin Biochem. 2018 Aug; 58:72-77 Epub 2018 May 18
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  33. Oduyebo I, Camilleri M, Nelson AD, Khemani D, Nord SL, Busciglio I, Burton D, Rhoten D, Ryks M, Carlson P, Donato L, Lueke A, Kim K, Rossi SJ, Zinsmeister AR. Effects of NGM282, an FGF19 variant, on colonic transit and bowel function in functional constipation: a randomized phase 2 trial. Am J Gastroenterol. 2018 May; 113 (5):725-734 Epub 2018 May 02
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  34. Vijayvargiya P, Busciglio I, Burton D, Donato L, Lueke A, Camilleri M. Bile Acid Deficiency in a Subgroup of Patients With Irritable Bowel Syndrome With Constipation Based on Biomarkers in Serum and Fecal Samples. Clin Gastroenterol Hepatol. 2018 Apr; 16 (4):522-527 Epub 2017 June 27
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  35. Donato LJ, Lueke A, Kenyon SM, Meeusen JW, Camilleri M. Description of analytical method and clinical utility of measuring serum 7-alpha-hydroxy-4-cholesten-3-one (7aC4) by mass spectrometry. Clin Biochem. 2018 Feb; 52:106-111 Epub 2017 Oct 16
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  36. Karon BS, Donato LJ, Larsen CM, Siebenaler LK, Wells AE, Wood-Wentz CM, Shirk-Marienau ME, Curry TB. Accuracy of Capillary and Arterial Whole Blood Glucose Measurements Using a Glucose Meter in Patients under General Anesthesia in the Operating Room. Anesthesiology. 2017 Sep; 127 (3):466-474
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  37. Vijayvargiya P, Camilleri M, Carlson P, Lueke A, O'Neill J, Burton D, Busciglio I, Donato L. Performance characteristics of serum C4 and FGF19 measurements to exclude the diagnosis of bile acid diarrhoea in IBS-diarrhoea and functional diarrhoea. Aliment Pharmacol Ther. 2017 Sep; 46 (6):581-588 Epub 2017 July 10
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  38. Whelton SP, Meeusen JW, Donato LJ, Jaffe AS, Saenger A, Sokoll LJ, Blumenthal RS, Jones SR, Martin SS. Evaluating the atherogenic burden of individuals with a Friedewald-estimated low-density lipoprotein cholesterol <70 mg/dL compared with a novel low-density lipoprotein estimation method. J Clin Lipidol. 2017 Jul - Aug; 11 (4):1065-1072 Epub 2017 June 01
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  39. Sepiashvili L, Dahl AR, Meeusen JW, Loftus CG, Donato LJ. A Man with Recurrent Ascites after Laparoscopic Cholecystectomy. Clin Chem. 2017 Jul; 63 (7):1199-1202
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  40. Meeusen JW, Donato LJ, Jaffe AS. Lipid Biomarkers for Risk Assessment in Acute Coronary Syndromes. Curr Cardiol Rep. 2017 Jun; 19 (6):48
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  41. Peleman C, Camilleri M, Busciglio I, Burton D, Donato L, Zinsmeister AR. Colonic Transit and Bile Acid Synthesis or Excretion in Patients With Irritable Bowel Syndrome-Diarrhea Without Bile Acid Malabsorption. Clin Gastroenterol Hepatol. 2017 May; 15 (5):720-727.e1 Epub 2016 Nov 14
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  42. Donato LJ, Meeusen JW, Jenkins SM, Hartman SJ, Saenger AK, Baumann NA, Block DR, Jaffe AS. Biological variability of lipoprotein-associated phospholipase A2 activity in healthy individuals. Clin Biochem. 2017 Apr; 50 (6):347-349 Epub 2016 Nov 25
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  43. Donato LJ, Karon BS. Working With Your Practice to Ensure Appropriate Point-of-Care Usage. J Appl Lab Med. 2017 Mar 1; 1 (5):603-604
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  44. Keddis MT, El-Zoghby Z, Kaplan B, Meeusen JW, Donato LJ, Cosio FG, Steidley DE. Soluble ST2 does not change cardiovascular risk prediction compared to cardiac troponin T in kidney transplant candidates. PLoS One. 2017; 12 (7):e0181123 Epub 2017 July 13
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  45. Lueke AJ, Meeusen JW, Donato LJ, Gray AV, Butterfield JH, Saenger AK. Analytical and clinical validation of an LC-MS/MS method for urine leukotriene E4: A marker of systemic mastocytosis. Clin Biochem. 2016 Sep; 49 (13-14):979-82 Epub 2016 Feb 18
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  46. Meeusen JW, Donato LJ, Jaffe AS. Should apolipoprotein B replace LDL cholesterol as therapeutic targets are lowered? Curr Opin Lipidol. 2016 Aug; 27 (4):359-66
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  47. Moyer AM, Saenger AK, Willrich M, Donato LJ, Baumann NA, Block DR, Botz CM, Khan MA, Jaffe AS, Hanson CA, Karon BS. Implementation of Clinical Decision Support Rules to Reduce Repeat Measurement of Serum Ionized Calcium, Serum Magnesium, and N-Terminal Pro-B-Type Natriuretic Peptide in Intensive Care Unit Inpatients. Clin Chem. 2016 Jun; 62 (6):824-30 Epub 2016 Mar 28
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  48. Acosta A, Camilleri M, Shin A, Linker Nord S, O'Neill J, Gray AV, Lueke AJ, Donato LJ, Burton DD, Szarka LA, Zinsmeister AR, Golden PL, Fodor A. Effects of Rifaximin on Transit, Permeability, Fecal Microbiome, and Organic Acid Excretion in Irritable Bowel Syndrome. Clin Transl Gastroenterol. 2016 May 26; 7:e173
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  49. Rajpurohit N, Gulati R, Lennon RJ, Singh M, Rihal CS, Santrach PJ, Donato LJ, Karon BS, Del-Carpio F, Tak T, Motiei A, Lopes RD, Gharacholou SM. Relation of Activated Clotting Times During Percutaneous Coronary Intervention to Outcomes. Am J Cardiol. 2016 Mar 1; 117: (5)703-8.
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  50. Donato LJ, Meeusen JW, Callanan H, Saenger AK, Jaffe AS. Advantages of the lipoprotein-associated phospholipase A2 activity assay. Clin Biochem. 2016 Jan; 49: (1-2)172-5.
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  51. Meeusen JW, Johnson JN, Gray A, Wendt P, Jefferies JL, Jaffe AS, Donato LJ, Saenger AK. Soluble ST2 and galectin-3 in pediatric patients without heart failure. Clin Biochem. 2015 Dec; 48 (18):1337-40 Epub 2015 Aug 12
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  52. Donato LJ, Karras RM, Katzmann JA, Murray DL, Snyder MR. Quantitation of circulating wild-type alpha-1-antitrypsin in heterozygous carriers of the S and Z deficiency alleles. Respir Res. 2015 Aug 5; 16:96 Epub 2015 Aug 05
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  53. Camilleri M, Acosta A, Busciglio I, Boldingh A, Dyer RB, Zinsmeister AR, Lueke A, Gray A, Donato LJ. Effect of colesevelam on faecal bile acids and bowel functions in diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther. 2015 Mar; 41 (5):438-48 Epub 2015 Jan 16
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  54. Donato LJ, Deobald GR, Wockenfus AM, Hornseth JM, Saenger AK, Karon BS. Comparison of two point of care devices for capillary lipid screening in fasting and postprandial adults. Clin Biochem. 2015 Feb; 48(3):174-6. Epub 2014 Nov 14.
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  55. Camilleri M, Shin A, Busciglio I, Carlson P, Acosta A, Bharucha AE, Burton D, Lamsam J, Lueke A, Donato LJ, Zinsmeister AR. Validating biomarkers of treatable mechanisms in irritable bowel syndrome. Neurogastroenterol Motil. 2014 Dec; 26 (12):1677-85 Epub 2014 Sept 22
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  56. Camilleri M, Busciglio I, Acosta A, Shin A, Carlson P, Burton D, Ryks M, Rhoten D, Lamsam J, Lueke A, Donato LJ, Zinsmeister AR. Effect of increased bile acid synthesis or fecal excretion in irritable bowel syndrome-diarrhea. Am J Gastroenterol. 2014 Oct; 109 (10):1621-30 Epub 2014 July 29
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  57. Donato LJ, Saenger AK, Train LJ, Kotzer KE, Lagerstedt SA, Hornseth JM, Basu A, Winters JL, Baudhuin LM. Genetic and biochemical analyses in dyslipidemic patients undergoing LDL apheresis. J Clin Apher. 2014 Oct; 29(5):256-65. Epub 2014 Jan 13.
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  58. Camilleri M, Shin A, Busciglio I, Carlson P, Acosta A, Bharucha AE, Burton D, Lamsam J, Lueke A, Donato LJ, Zinsmeister AR. Genetic variation in GPBAR1 predisposes to quantitative changes in colonic transit and bile acid excretion. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1; 307 (5):G508-16 Epub 2014 July 10
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  59. Bancos I, Algeciras-Schimnich A, Grebe SK, Donato LJ, Nippoldt TB, Erickson D. Evaluation of Variables Influencing the Measurement of Insulin-like Growth Factor-1. Endocr Pract. 2014 May; 20 (5):421-6
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  60. Bancos I, Algeciras-Schimnich A, Woodmansee WW, Cullinane AK, Donato LJ, Nippoldt TB, Natt N, Erickson D. Determination of nadir growth hormone concentration cutoff in patients with acromegaly. Endocr Pract. 2013 Nov-Dec; 19 (6):937-45
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  61. Donato LJ, Jenkins SM, Smith C, Katzmann JA, Snyder MR. Reference and interpretive ranges for alpha(1)-antitrypsin quantitation by phenotype in adult and pediatric populations. Am J Clin Pathol. 2012 Sep; 138(3):398-405.
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  62. Baudhuin LM, Donato LJ, Uphoff TS. How novel molecular diagnostic technologies and biomarkers are revolutionizing genetic testing and patient care. Expert Rev Mol Diagn. 2012 Jan; 12(1):25-37.
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  63. Donato LJ, Zeldenrust SR, Murray DL, Katzmann JA. A 71-year-old woman with multiple myeloma status after stem cell transplantation. Clin Chem. 2011 Dec; 57 (12):1645-8
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  64. Donato LJ. Reportable ranges for HbA1c test. MLO Med Lab Obs. 2011 Sep; 43(9):31-3.
  65. Stevens MJ, Donato LJ, Lower SK, Sahai N. Oxide-dependent adhesion of the Jurkat line of T lymphocytesLangmuir. Langmuir. 2009 Jun 2; 25(11):6270-8.
  66. Moretti R, Donato LJ, et al.(Both are co-first authors). Sequence specific chemical wedges reveal the contribution of allosteric DNA modualtion in protein-DNA assembly. ACS Chem Biol. 2008 Apr 18; 3(4):220-9.
  67. Donato LJ, Suh JH, Noy N. Suppression of mammary carcinoma cell growth by retinoic acid: the cell cycle control gene Btg2 is a direct target for retinoic acid receptor signaling. Cancer Res. 2007 Jan 15; 67(2):609-15.
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  68. Donato LJ, Suh JH, Noy N. Suppression of mammary carcinoma growth by retinoic acid: cell cycle control genes are targets for RAR and CRABP-II signaling. Cancer Res (2):609-15. 2007 Jan 15; 67(2):609-15.
  69. Donato LJ, Noy N. A fluorescence-based method for analyzing retinoic acid in biological samples. Anal Biochem. 2006 Oct 15; 357(2):249-56. Epub 2006 Aug 02.
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  70. Donato LJ, Noy N. A fluorescence-based assay for analyzing retinoic acid in biological samples. Anal Biochem. 2006 Oct 15; 357(2):249-56.
  71. Donato LJ, Noy N. Suppression of mammary carcinoma growth by retinoic acid: proapoptotic genes are targets for retinoic acid receptor and cellular retinoic acid-binding protein II signaling. Cancer Res. 2005 Sep 15; 65(18):8193-9.
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PST-20514356