Stages

If you're diagnosed with cutaneous B-cell lymphoma, the next step is to determine the cancer's extent, called the stage. Biopsies, imaging tests and blood tests may be used to determine the stage of a B-cell lymphoma. Your healthcare team uses the cancer stage to help create your treatment plan.

Stages for other types of cancer often have numbers, such as stage 1, 2, 3 and 4. Cutaneous B-cell lymphoma doesn't have those stages. Instead, the stage describes how much of the body is affected by cancer. Cutaneous B-cell lymphoma is staged using the TNM staging system. TNM stands for tumor, node and metastases.

For cutaneous B-cell lymphoma, tumor refers to the number of lesions present on the skin, where they are located and how big they are:

  • T0. No lesions are present.
  • T1. Only one patch, lesion or nodule is present in one area of the skin.
  • T2. Multiple lesions are present. The lesions may be close together in one area of the skin or located in two areas of the skin that are near each other.
  • T3. Multiple lesions are present in multiple areas of the skin not near each other.

Node refers to whether the lymph nodes are affected:

  • N0. No lymph nodes are affected.
  • N1. One lymph node region is affected.
  • N2. More than two lymph node regions are affected.
  • N3. The cancer has spread to the central lymph nodes.

Metastases refers to whether the cancer has spread to other parts of the body:

  • M0. The cancer has not spread beyond the skin.
  • M1. The cancer has spread to other organs, such as the liver, lungs, bone marrow or spleen.

For example, an early-stage cutaneous B-cell lymphoma may be labeled as T1N0M0. A late-stage cutaneous B-cell lymphoma that is more aggressive and has spread beyond the skin may be labeled as a T3N3M1. Once it spreads beyond the skin it is no longer treated as a cutaneous lymphoma but rather a systemic lymphoma.

Cutaneous B-cell lymphoma prognosis

The cancer prognosis tells you how likely it is that the cancer can be treated successfully. Your personal prognosis may depend on:

  • Your age.
  • Your overall health.
  • How much of the body is affected by cancer.
  • Your blood test results.

Talk with your healthcare team about your prognosis if you want to know what to expect. Members of your healthcare team can explain what they consider when thinking about your prognosis.

17/01/2025

Living with لمفومة الخلايا البائية الجلدية?

Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community.

Blood Cancers & Disorders Discussions

Lori, Volunteer Mentor
My Bone Marrow Transplant (BMT/SCT) story: Will you share yours?

814 Replies Sat, Jan 10, 2026

dburkert
T cell large granulocytic leukemia

33 Replies Sat, Jan 10, 2026

frank0508
High Ferritin Levels: How can I lower my levels?

32 Replies Wed, Jan 07, 2026

See more discussions
  1. Primary cutaneous lymphomas. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1491. Accessed Oct. 10, 2024.
  2. Bolognia JL, et al. B-cell lymphomas of the skin. In: Dermatology. 5th ed. Elsevier; 2025. https://www.clinicalkey.com. Accessed Oct. 15, 2024.
  3. Cerroni L, et al. Infection by Borrelia burgdorferi and cutaneous B-cell lymphoma. Journal of Cutaneous Pathology. 1997; doi:10.1111/j.1600-0560.1997.tb01318.x.

لمفومة الخلايا البائية الجلدية