طب القلب والأوعية الدموية

بالأسفل التجارب السريرية الحالية.

غربل قائمة الدراسات هذه بالموقع والحالة وغيرها.

1. A Study Testing the Philips Scanner Technology for Reliable Respiratory Assessment

   Rochester, Minn.

   The purpose of this study is to test the Philips Camera bar code scanner with actual patients, to assess its effectiveness in measuring breaths inspite of common obstructions.

2. A Study of the Mayo Clinic College of Medicine Ultrasound System

   Rochester, Minn.

   The purpose of this study is is to assess the EPIQ-Affiniti and NG Compact ultrasound systems in a clinical environment and collect clinical data and feedback when compared to the site’s standard ultrasound system.

3. Surgical Outcomes of Mitral Valve Repair

   Rochester, Minn.

   The purpose of this study is to learn more about early and late outcomes in patients after mitral valve repair.

4. A Study to Evaluate Potential Myocardial Injury in Patients with Cardiac Implantable Electronic Devices Undergoing Defibrillation Threshold Testing

   Rochester, Minn.

   The purpose of this study is to determine if defibrillation threshold testing (DFT) results in myocardial injury as assessed by changes in high sensitivity cardiac troponin T (hs-cTnT). This will be done by comparing pre-and-post DFT hs-cTnT levels in these patients.

5. A Study to Determine the Impact of Individualized Estrogen Therapy on Cardiovascular Disease Risk Parameters in Young Women after Bilateral Oophorectomy

   Rochester, Minn.

   The purpose of this study is to compare the cardiovascular function in young women (<46 years) following bilateral oophorectomy who are treated with either the standard dose of estradiol (100 mcg transdermal patch or equivalent oral dose) or titrated estradiol dosing to achieve average premenopausal estradiol level (80-120 pg/ml), to characterize the relationship between the serum estradiol level and cardiovascular function in young women (<46 years) on estradiol replacement after bilateral oophorectomy, and to compare the body composition in young women following bilateral oophorectomy who are treated with either the standard dose of estradiol (100 mcg transdermal patch or equivalent oral dose) or titrated estradiol dosing to achieve average premenopausal estradiol level (80-120 pg/ml).

6. A Study to Evaluate Decision-support Interventions for Atrial Fibrillation (RED-AF)

   Rochester, Minn.

   1. The primary purpose of this study is to assess the comparative effectiveness of the following 4 approaches to promote high-quality SDM for at-risk patients with AF:  a PDA alone, (2) an EDA alone, (3) a combination of a PDA and an EDA, and (4) control with neither a PDA nor an EDA.

    

7. Is Our Microbiome a Predictor of Cardiac Risk

   Rochester, Minn.

   The purpose of this study is to compare the fecal microbiota of patients with mild, moderate and severe Coronary Artery Disease (CAD) by collecting stool and blood samples from patients undergoing coronary angiograms.

    

8. Identification of Novel Genetic Variants and Biomarkers of Disease Progression in Arrhythmogenic Cardiomyopathy

   Rochester, Minn.

   The purpose of this study is to identify hereditary causes of cardiomyopathy.

9. Stress Echocardiography in Mixed and Multi Valvular Heart Disease

   Rochester, Minn.

   The purpose of this study is to: investigate the diagnostic utility of stress echocardiography (SE) in the evaluation of patients with mixed and mult-valvular heart disease (mx/ml-VHD), evaluate the hemodynamic impact of exercise on mx/ml-VHD compared to those with isolated valve disease, study the prevalence and natural history of mx/ml-VHD, and identify clinical, echocardiographic and biochemical markers that can be used to identify patients with mx/ml-VHD who are at higher risk for future cardiovascular events.

10. International Bicuspid Aortic Valve Consortium (BAVCon)

    Rochester, Minn.

    Bicuspid aortic valve (BAV) disease is the most frequent congenital cardiac malformation, occurring in 0.5-1.2% of the US population. In young adults, it is generally a benign abnormality; but in older adults it is associated with thoracic aortic aneurysm or dissection in 20-30% of those with BAV. BAV is strongly associated with early development of aortic valve calcification or incompetence in >50% of BAV patients, and accounts for ~40% of the >30,000 aortic valve replacements (AVR) performed in the US each year. Yet, we know little of the etiology, cellular events and modifiers of progression of BAV to calcific aortic valve disease and we still do not understand the genetic cause(s) of BAV despite evidence for its high heritability.

    The Specific Aims of this study are:

    1. To identify the genetic causes of bicuspid aortic valve disease and its associated thoracic aortic disease.

    2. To identify potential pathways to predict the clinical course of BAV disease and for treating human BAV disease.

    To achieve these aims, we have created the International Bicuspid Aortic Valve Consortium (BAVCon), a consortium of institutions with cohorts of BAV patients and the expertise to fulfill the performance of these aims.