Ulcerative colitis (UL-sur-uh-tiv koe-LIE-tis) is an inflammatory bowel disease (IBD) that causes long-lasting inflammation in part of your digestive tract.
Like Crohn's disease, another common IBD, ulcerative colitis can be debilitating and sometimes can lead to life-threatening complications. Because ulcerative colitis is a chronic condition, symptoms usually develop over time, rather than suddenly.
Ulcerative colitis usually affects only the innermost lining of your large intestine (colon) and rectum. It occurs only through continuous stretches of your colon, unlike Crohn's disease, which occurs anywhere in the digestive tract and often spreads deeply into the affected tissues.
There's no known cure for ulcerative colitis, but therapies are available that may dramatically reduce the signs and symptoms of ulcerative colitis and even bring about a long-term remission.
Oct. 10, 2012
- Ulcerative colitis. National Institute of Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/colitis/. Accessed July 1, 2011.
- About ulcerative colitis and proctitis. The Crohn's and Colitis Foundation of America. http://www.ccfa.org/frameviewer/?url=/media/pdf/livingwithuc52010.pdf. Accessed July 1, 2011.
- Ulcerative colitis. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merckmanuals.com/professional/print/sec02/ch018/ch018c.html. Accessed July 1, 2011.
- Shale M, et al. Isotretinoin and intestinal inflammation: What gastroenterologists need to know. Gut. 2009;58:737.
- Burakoff R, et al. Inflammatory bowel disease. In: Greenberger NJ, et al. Current Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy. New York, N.Y.: The McGraw Hill Medical Companies; 2009. http://www.accessmedicine.com/content.aspx?aID=6200149. Accessed June 20, 2011.
- Peppercorn MA, et al. Medical management of ulcerative colitis. http://www.uptodate.com/home/index.html. Accessed June 30, 2011.
- Ulcerative colitis practice guidelines in adults. Bethesda, Md.: American College of Gastroenterology. http://www.acg.gi.org/physicians/guidelines/UlcerativeColitis.pdf. Accessed June 20, 2011.
- Rutgeerts P, et al. Biological therapies for inflammatory bowel diseases. Gastroenterology. 2009;136:1182.
- IBD and pregnancy: What you need to know. Crohn's and Colitis Foundation of America. http://www.ccfa.org/about/news/pregnancy. Accessed July 2, 2011.
- Enck P. Acupuncture treatment in gastrointestinal diseases: A systematic review. World Journal of Gastroenterology. 2007;13:3417.
- Fact sheet: Complementary and alternative medicine. Crohn's and Colitis Foundation of America. http://www.ccfa.org/frameviewer/?url=/media/pdf/FactSheets/CAM.pdf. Accessed July 1, 2011.
- Taylor RA, et al. Curcumin for inflammatory bowel disease: A review of human studies. Alternative Medicine Review. 2011;16:152.
- Picco MF (expert review). Mayo Clinic, Jacksonville, Fla. July 11, 2011.
- Colorectal cancer screening guidelines. U.S. Centers for Disease Control and Prevention. http://www.cdc.gov/cancer/colorectal/basic_info/screening/guidelines.htm. Accessed July 12, 2011.
- Reddy D, et al. Possible association between isotretinoin and inflammatory bowel disease. American Journal of Gastroenterology. 2006;101:1569.
- Crockett SD, et al. A causal association between isotretinoin and inflammatory bowel disease has yet to be established. American Journal of Gastroenterology. 2009;104:2387.
- Crockett SD, et al. Isotretinoin use and the risk of inflammatory bowel disease: A case-control study. American Journal of Gastroenterology. 2010;105:1986.
- Bernstein CN, et al. Isotretinoin is not associated with inflammatory bowel disease: A population-based case-control study. American Journal of Gastroenterology. 2009;104:2744.
- Margolis DJ, et al. Potential association between the oral tetracycline class of antimicrobials used to treat acne and inflammatory bowel disease. American Journal of Gastroenterology. 2010;105:2610.
- Loftus EV (expert opinion). Mayo Clinic, Rochester, Minn. Sept. 21, 2011.