Inflammatory bowel disease symptoms vary, depending on the severity of inflammation and where it occurs.
Ulcerative colitis symptoms
Ulcerative colitis is classified according to its signs and symptoms:
- Ulcerative proctitis. In this form of ulcerative colitis, inflammation is confined to the area closest to the anus (rectum), and for some people, rectal bleeding may be the only sign of the disease. Others may have rectal pain, a feeling of urgency or have frequent, small bowel movements. This form of ulcerative colitis tends to be the mildest.
- Proctosigmoiditis. This form involves the rectum and the lower end of the colon, known as the sigmoid colon. Bloody diarrhea, abdominal cramps and pain, and an inability to move the bowels in spite of the urge to do so (tenesmus) are common problems associated with this form of the disease.
- Left-sided colitis. As the name suggests, inflammation extends from the rectum up through the sigmoid and descending colon, which are located in the upper left part of the abdomen. Signs and symptoms include bloody diarrhea, abdominal cramping and pain on the left side, and unintended weight loss.
- Pancolitis. Affecting more than the left colon and often the entire colon, pancolitis causes bouts of bloody diarrhea that may be severe, abdominal cramps and pain, fatigue, and significant weight loss.
- Fulminant colitis. This rare, life-threatening form of colitis affects the entire colon and causes severe pain, profuse diarrhea and, sometimes, dehydration and shock. People with fulminant colitis are at risk of serious complications, including colon rupture and toxic megacolon, a condition that causes the colon to rapidly expand.
The course of ulcerative colitis varies, with periods of acute illness often alternating with periods of remission. Most people with a milder condition, such as ulcerative proctitis, won't go on to develop more-severe signs and symptoms.
Crohn's disease symptoms
Inflammation of Crohn's disease may involve different parts of the digestive tract in different people. The most common areas affected by Crohn's disease are the last part of the small intestine called the ileum and the colon. Inflammation may be confined to the bowel wall, which can lead to scarring (stenosis), or inflammation may spread through the bowel wall (fistula).
Signs and symptoms of Crohn's disease can range from mild to severe and may develop gradually or come on suddenly, without warning. Signs and symptoms may include:
- Diarrhea. The inflammation that occurs in Crohn's disease causes cells in the affected areas of your intestine to secrete large amounts of water and salt. Because the colon can't completely absorb this excess fluid, you develop diarrhea. Intensified intestinal cramping also can contribute to loose stools. Diarrhea is a common problem for people with Crohn's.
- Abdominal pain and cramping. Inflammation and ulceration may cause the walls of portions of your bowel to swell and eventually thicken with scar tissue. This affects the normal movement of contents through your digestive tract and may lead to pain and cramping. Mild Crohn's disease usually causes slight to moderate intestinal discomfort, but in more-serious cases, the pain may be severe and include nausea and vomiting.
- Blood in your stool. Food moving through your digestive tract may cause inflamed tissue to bleed, or your bowel may also bleed on its own. You might notice bright red blood in the toilet bowl or darker blood mixed with your stool. You can also have bleeding you don't see (occult blood).
- Ulcers. Crohn's disease and ulcerative colitis can cause small sores on the surface of the intestine that eventually become large ulcers that penetrate deep into — and sometimes through — the intestinal walls. You may also have ulcers elsewhere, including in your mouth similar to canker sores.
- Reduced appetite and weight loss. Abdominal pain and cramping and inflammation of your bowel wall can affect both your appetite and your ability to digest and absorb food.
People with severe Crohn's disease may also experience:
- Eye inflammation
- Skin disorders
- Inflammation of the liver or bile ducts
- Delayed growth or sexual development, in children
When to see a doctor
See your doctor if you experience a persistent change in your bowel habits or if you have any of the signs and symptoms of inflammatory bowel disease. Although inflammatory bowel disease usually isn't fatal, it's a serious disease that, in some cases, may cause life-threatening complications.
Dec. 13, 2012
- Ulcerative colitis. National Institute of Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/colitis/. Accessed July 1, 2011.
- Living with ulcerative colitis. The Crohn's and Colitis Foundation of America. http://www.ccfa.org/frameviewer/?url=/media/pdf/livingwithuc52010.pdf. Accessed July 1, 2011.
- Ulcerative colitis. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merckmanuals.com/professional/print/sec02/ch018/ch018c.html. Accessed July 1, 2011.
- Shale M, et al. Isotretinoin and intestinal inflammation: What gastroenterologists need to know. Gut. 2009;58:737.
- Burakoff R, et al. Inflammatory bowel disease. In: Greenberger NJ, et al. Current Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy. New York, N.Y.: The McGraw-Hill Companies; 2009. http://www.accessmedicine.com/content.aspx?aID=6200149. Accessed June 20, 2011.
- Peppercorn MA, et al. Medical management of ulcerative colitis. http://www.uptodate.com/home/index.html. Accessed June 30, 2011.
- Ulcerative colitis practice guidelines in adults. Bethesda, Md.: American College of Gastroenterology. http://www.acg.gi.org/physicians/guidelines/UlcerativeColitis.pdf. Accessed June 20, 2011.
- Rutgeerts P, et al. Biological therapies for inflammatory bowel diseases. Gastroenterology. 2009;136:1182.
- IBD and pregnancy: What you need to know. Crohn's and Colitis Foundation of America. http://www.ccfa.org/about/news/pregnancy. Accessed July 2, 2011.
- Enck P. Acupuncture treatment in gastrointestinal diseases: A systematic review. World Journal of Gastroenterology. 2007;13:3417.
- Fact sheet: Complementary and alternative medicine. Crohn's and Colitis Foundation of America. http://www.ccfa.org/frameviewer/?url=/media/pdf/FactSheets/CAM.pdf. Accessed July 1, 2011.
- Taylor RA, et al. Curcumin for inflammatory bowel disease: A review of human studies. Alternative Medicine Review. 2011;16:152.
- Picco MF (expert opinion). Mayo Clinic, Jacksonville, Fla. July 22, 2011.
- Colorectal cancer screening guidelines. Centers for Disease Control and Prevention. http://www.cdc.gov/cancer/colorectal/basic_info/screening/guidelines.htm. Accessed July 12, 2011.
- Crohn's disease. National Institute of Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/crohns/Crohns.pdf. Accessed June 20, 2011.
- Management of Crohn's disease in adults. Bethesda, Md.: American College of Gastroenterology. http://www.acg.gi.org/physicians/guidelines/CrohnsDiseaseinAdults2009.pdf. Accessed June 20, 2011.
- Living with Crohn's disease. The Crohn's and Colitis Foundation of America. http://www.ccfa.org/frameviewer/?url=/media/pdf/crohns2005.pdf. Accessed June 20, 2011.
- Crohn's disease. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merckmanuals.com/professional/print/sec02/ch018/ch018b.html. Accessed June 20, 2011.
- Peppercorn MA. Clinical manifestations, diagnosis and natural history of Crohn's disease in adults. http://www.uptodate.com/home/index.html. Accessed June 20, 2011.
- Smoking and your digestive system. National Institute of Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/smoking/DD-52.pdf. Accessed June 23, 2011.
- Ford AC, et al. Glucocorticosteroid therapy in inflammatory bowel disease: Systematic review and meta-analysis. American Journal of Gastroenterology. 2011;106:590.
- Colombel JF, et al. Infliximab, azathioprine, or combination therapy for Crohn's disease. New England Journal of Medicine. 2010;362:1383.
- Farrell RJ, et al. Medical management of Crohn's disease in adults. http://www.uptodate.com/home/index.html. Accessed June 20, 2011.
- Korzenik JR. Investigational therapies in the medical management of Crohn's disease. http://www.uptodate.com/home/index.html. Accessed June 20, 2011.
- Ford AC, et al. Efficacy of biological therapies in inflammatory bowel disease: Systematic review and meta-analysis. American Journal of Gastroenterology. 2011;106:644.
- Markowitz J, et al. Patterns of complementary and alternative medicine use in a population of pediatric patients with inflammatory bowel disease. Inflammatory Bowel Diseases. 2004;10:599.
- Stenson WF. Inflammatory bowel disease. In: Goldman L, et al. Cecil Medicine. 23rd ed. Philadelphia, Pa.: Saunders Elsevier; 2008. http://www.mdconsult.com/das/book/body/191371208-2/0/1492/0.html#. Accessed July 12, 2011.
- Reddy D, et al. Possible association between isotretinoin and inflammatory bowel disease. American Journal of Gastroenterology. 2006;101:1569.
- Crockett SD, et al. A causal association between isotretinoin and inflammatory bowel disease has yet to be established. American Journal of Gastroenterology. 2009;104:2387.
- Crockett SD, et al. Isotretinoin use and the risk of inflammatory bowel disease: A case-control study. American Journal of Gastroenterology. 2010;105:1986.
- Bernstein CN, et al. Isotretinoin is not associated with inflammatory bowel disease: A population-based case-control study. American Journal of Gastroenterology. 2009;104:2744.
- Margolis DJ, et al. Potential association between the oral tetracycline class of antimicrobials used to treat acne and inflammatory bowel disease. American Journal of Gastroenterology. 2010;105:2610.
- Loftus EV (expert opinion). Mayo Clinic, Rochester, Minn. Sept. 21, 2011.