Mayo Clinic's approach

Collaboration

At Mayo Clinic, radiation oncologists, medical oncologists and pathologists work together as a team to provide exactly the treatment and care you need for your specific condition. Other professionals are included as needed.

Advanced diagnosis and treatment

Mayo Clinic radiation specialists are experts in planning radiation treatment that targets diseased tissue and spares as much healthy tissue as possible. Mayo Clinic uses SBRT to treat tumors in many parts of the body, including the lung, spine, liver, lymph nodes, prostate and other soft tissues.

At Mayo Clinic, SBRT is used to treat a range of conditions, including early-stage lung cancer, localized prostate cancer, and selected tumors that have returned or spread to a small number of sites. Treatment is planned and delivered by multidisciplinary teams using advanced imaging and precision radiation techniques.

Proton beam therapy

Mayo Clinic's campus in Arizona and Mayo Clinic's campus in Minnesota have a proton beam therapy facility, dedicated to providing the latest stereotactic body radiotherapy technology. Mayo Clinic's Proton Beam Therapy Program is the only National Cancer Institute-designated comprehensive cancer center with a multisite presence, with locations in Arizona and Minnesota.

Proton beam therapy uses intensity-modulated proton treatment with pencil beam scanning. This technology allows radiation to be shaped closely to the tumor, which may help limit radiation exposure to nearby healthy tissue. In selected cases, proton therapy may be used as part of SBRT planning or other advanced radiation approaches.

Research pioneers

Mayo Clinic doctors working in cancer research have contributed greatly to the understanding of SBRT and have published widely on the results of their research. This emphasis on research increases the treatment choices available to Mayo Clinic patients. A variety of clinical trials and other studies may be available to you at Mayo Clinic.

Expertise and rankings

Nationally recognized

The Mayo Clinic Comprehensive Cancer Center meets the strict standards for a National Cancer Institute comprehensive cancer center. These standards recognize scientific excellence and a multispecialty approach focused on cancer prevention, diagnosis and treatment.

Mayo Clinic has been recognized as a top cancer hospital by U.S. News & World Report since it began publishing rankings in 1990. Most recently, Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Jacksonville, Florida, and Mayo Clinic in Phoenix/Scottsdale, Arizona, have been recognized among the top Cancer hospitals in the nation by U.S. News & World Report.

Locations, travel and lodging

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

For more information on visiting Mayo Clinic, choose your location below:

Costs and insurance

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.

In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Learn more about appointments at Mayo Clinic.

Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.

More information about billing and insurance:

Mayo Clinic in Arizona, Florida and Minnesota

Mayo Clinic Health System

Feb. 06, 2026
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  3. Das IJ, et al. Quality and safety considerations in stereotactic radiosurgery and stereotactic body radiation therapy: An ASTRO safety white paper update. Practical Radiation Oncology. 2022; doi:10.1016/j.prro.2022.03.001.
  4. Liu W, et al. NRG Oncology and Particle Therapy Co-Operative Group patterns of practice survey and consensus recommendations on pencil-beam scanning proton stereotactic body radiation therapy and hypofractionated radiation therapy for thoracic malignancies. International Journal of Radiation Oncology, Biology, Physics. 2024; doi:10.1016/j.ijrobp.2024.01.216.
  5. Beddok A, et al. Reirradiation: Standards, challenges, and patient-focused strategies across tumor types. CA: A Cancer Journal for Clinicians. 2025; doi:10.3322/caac.70016.
  6. Sekar V, et al. Radiation therapy, radiosurgery, chemotherapy and targeted therapies for metastatic spine tumors: WFNS Spine committee recommendations. Neurosurgical Reviews. 2024; doi:10.1007/s10143-024-03123-3.
  7. Sourial F, et al. Use of ablative radiotherapy in the setting of oligometastatic disease. JCO Oncology Practice. 2025; doi:10.1200/OP-25-00272.
  8. Beriwal S, et al., eds. Stereotactic radiosurgery. In: Radiation-Oncology Therapy. McGraw Hill; 2025. https://hemonc.mhmedical.com. Accessed Dec. 5, 2025.

Stereotactic body radiotherapy