Hormone therapy for prostate cancer

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Mayo Clinic's approach

The top-ranked doctors at Mayo Clinic provide expert care for those with prostate cancer. At Mayo Clinic, you can expect:

  • Advanced treatment options. At Mayo Clinic, specialists have access to the latest treatment innovations, including clinical trials, even after hormone therapy stops working.
  • Collaboration. At Mayo Clinic, oncologists, urologists, radiation oncologists, pathologists and radiologists work as a multidisciplinary team to provide comprehensive care for people with prostate cancer.
  • Experienced care teams. Each year, thousands of people with prostate cancer receive care at Mayo Clinic. This experience means your care team is prepared with knowledge and resources to provide you with exactly the care you need. Mayo specialists are deeply experienced not just in one specific aspect of the disease but across all the specialties involved in prostate cancer care.
  • Nationally recognized expertise. Mayo Clinic Comprehensive Cancer Center meets the strict standards for a National Cancer Institute-designated comprehensive cancer center. These standards recognize scientific excellence and a multispecialty approach focused on cancer prevention, diagnosis and treatment. Mayo Clinic Comprehensive Cancer Center is the only National Cancer Institute-designated comprehensive cancer center with three locations, in Arizona, Florida and Minnesota.

Expertise and rankings

Mayo Clinic has been recognized as a top cancer hospital by U.S. News & World Report since it began publishing rankings in 1990. Most recently, Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Jacksonville, Florida, and Mayo Clinic in Phoenix/Scottsdale, Arizona, have been recognized among the top Cancer hospitals in the nation by U.S. News & World Report.

Mayo Clinic's campus in Arizona

Mayo Clinic's campus in Florida

Mayo Clinic's campus in Minnesota

Mayo Clinic Health System

Mayo Clinic Healthcare, located in London

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Mayo Clinic in Arizona, Florida and Minnesota

Mayo Clinic Health System

By Mayo Clinic Staff
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Doctors & Departments
July 15, 2025
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  1. Prostate cancer. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1459. Accessed May 27, 2025.
  2. Prostate cancer: Early stage. National Comprehensive Cancer Network. https://www.nccn.org/patientresources/patient-resources/guidelines-for-patients/guidelines-for-patients-details?patientGuidelineId=49. Accessed May 27, 2025.
  3. Lowrance W, et al. Updates to advanced prostate cancer: AUA/SUO guideline (2023). The Journal of Urology. 2023; doi:10.1097/JU.0000000000003452.
  4. Hormone therapy for prostate cancer. National Cancer Institute. https://www.cancer.gov/types/prostate/prostate-hormone-therapy-fact-sheet. Accessed May 27, 2025.
  5. Smith MR. Side effects of androgen deprivation therapy. https://www.uptodate.com/contents/search. Accessed Feb. 16, 2023.
  6. Dmochowski RR, et al., eds. Management of recurrent and newly metastatic prostate cancer. In: Campbell-Walsh-Wein Urology. 13th ed. Elsevier; 2026. https://www.clinicalkey.com. Accessed May 27, 2025.
  7. Hussain M, et al. Metastatic hormone-sensitive prostate cancer and combination treatment outcomes: A review. JAMA Oncology. 2024; doi:10.1001/jamaoncol.2024.0591.
  8. Hamid AA, et al. Metastatic hormone-sensitive prostate cancer: Toward an era of adaptive and personalized treatment. American Society of Clinical Oncology Educational Book. 2023; doi:10.1200/EDBK_390166.
  9. Gudenkauf LM, et al. Balancing hormone therapy: Mitigating adverse effects of androgen-deprivation therapy and exploring alternatives in prostate cancer management. American Society of Clinical Oncology Educational Book. 2024; doi:10.1200/EDBK_433126.
  10. Boue A, et al. Does hormone therapy impact cognition in patients with prostate cancer? A systematic review and meta-analysis. Cancer. 2024; doi:10.1002/cncr.35210.
  11. Solanki AJ, et al. A practical guide for assessing and managing cardiovascular risk during androgen-deprivation therapy in patients with prostate cancer. Cancer. 2024; doi:10.1002/cncr.35285.
  12. Lupron (prescribing information). AbbVie Inc.; 2023. https://www.lupron.com/pi.html. Accessed June 6, 2025.
  13. Zoladex (prescribing information). AstraZeneca Pharmaceuticals LP; 2023. https://www.zoladexhcp.com/dosing-administration/. Accessed June 6, 2025.
  14. Vaz R, et al. Testicular cancer — Surgical treatment. Frontiers in Endocrinology. 2019; doi:10.3389/fendo.2019.00308.
  15. Dawson NA, et al. Overview of the treatment of castration-resistant prostate cancer (CRPC). https://www.uptodate.com/contents/search. Accessed June 12, 2025.
  16. Hormone therapy for prostate cancer. National Cancer Institute. https://www.cancer.gov/types/prostate/prostate-hormone-therapy-fact-sheet. Accessed June 12, 2025.
  17. Harris WP, et al. Androgen deprivation therapy: Progress in understanding mechanisms of resistance and optimizing androgen depletion. Nature Clinical Practice Urology; 2009. doi:10.1038/ncpuro1296.
  18. Cancer stat facts: Prostate cancer. National Cancer Institute. https://seer.cancer.gov/statfacts/html/prost.html. Accessed June 12, 2025.
  19. Harris KM. Allscripts EPSi. Mayo Clinic. April 23, 2024.
  20. Questions to ask about prostate cancer. American Cancer Society. https://www.cancer.org/cancer/types/prostate-cancer/detection-diagnosis-staging/talking-with-doctor.html. Accessed June 18, 2025.
  21. Questions to ask about cancer care. National Comprehensive Cancer Network. https://www.nccn.org/patientresources/patient-resources/resources-for-patients-caregivers/questions-to-ask-about-cancer. Accessed June 18, 2025.
  22. Anheuser P, et al. Complications associated with inguinal orchiectomy and scrotal orchiectomy. Urologe. 2014; doi:10.1007/s00120-014-3487-3.
  23. Hormone therapy for advanced prostate cancer. Mayo Clinic Press. https://mcpress.mayoclinic.org/cancer/hormone-therapy-for-advanced-prostate-cancer. Accessed June 18, 2025.

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Hormone therapy for prostate cancer