Mayo Clinic's approach


The Transgender and Intersex Specialty Care Clinic (TISCC) provides integrated medical, psychosocial and surgical intervention to individuals with gender dysphoria or incongruence and to those with disorders of sexual development. The team includes providers from various specialties including endocrinology, pediatric endocrinology, social work, psychiatry, psychology, voice therapy, gynecology and plastic surgery.


Treatments offered include:

  • Mental health assessment and management
  • Hormonal therapy and monitoring
  • Assistance with social and legal issues and referrals to community resources
  • Fertility preservation
  • Sexually transmitted infection screening and pre-exposure prophylaxis (PrEP)
  • Voice therapy
  • Electrolysis and laser hair removal
  • Hair transplant
  • Gynecologic care for trans men
  • Chaplain services
  • Feminizing surgical procedures:
    • Breast augmentation
    • Facial feminization
    • Body contouring procedures
    • Orchiectomy
    • Tracheal shave
    • Penile inversion vaginoplasty
  • Masculinizing surgical procedures:
    • Breast reduction/chest masculinization
    • Body contouring procedures
    • Hysterectomy/oophorectomy

Before you start treatment, you will meet with at least one member of the TISCC medical team, a doctor or nurse practitioner, and the TISCC mental health team, a social worker, psychologist, or psychiatrist. You'll have a complete medical evaluation to make sure that your treatment risks are identified and addressed. Evaluation of your mental health ensures that any mood or mental health concerns are reasonably well managed before treatment begins.

Each person is different. Your providers will look at your specific case in order to come up with the best recommendations for you. Your health care team will work with you during your treatment and make sure that your expectations are realistic. Your team wants to make sure that your goals are being met, any risks are reduced and managed, and your questions are answered.


Mayo Clinic specialists are committed to providing the latest, most comprehensive treatment options for gender dysphoria. Your Mayo Clinic specialist's advice about the best treatment for you will be based on expert knowledge of and experience with all treatment options for gender dysphoria.

Expertise and rankings

At Mayo Clinic, endocrinologists, psychiatrists, psychologists, nurse practitioners, social workers and surgeons work together to provide exactly the care you need.

Having all of this expertise in a single place, focused on you, means that you're not just getting one opinion — your care is discussed among the team, your test results are available quickly, your appointments are scheduled in coordination and highly specialized experts are all working together to determine what's best for you.

Locations, travel and lodging

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

For more information on visiting Mayo Clinic, choose your location below:

Costs and insurance

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.

In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals, or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Learn more about appointments at Mayo Clinic.

Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.

More information about billing and insurance:

Mayo Clinic in Arizona, Florida and Minnesota

Mayo Clinic Health System

Clinical trials

Explore Mayo Clinic studies of tests and procedures to help prevent, detect, treat or manage conditions.

Sept. 11, 2019
  1. Ferrando C, et al. Transgender surgery: Male to female. contents/search. Accessed April 15, 2019.
  2. Erickson-Schroth L, ed. Surgical transition. In: Trans Bodies, Trans Selves: A Resource for the Transgender Community. New York, N.Y.: Oxford University Press; 2014.
  3. The World Professional Association of Transgender Health. Standards of care for the health of transsexual, transgender and gender nonconforming people, 7th version. Accessed April 15, 2019.
  4. AskMayoExpert. Feminizing or masculinizing procedures. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2019.
  5. Morrison SD, et al. Facial feminization: Systematic review of the literature. Plastic and Reconstructive Surgery. 2016;137:1759.
  6. Deschamps-Braly JC. Facial gender confirmation surgery: Facial feminization surgery and facial masculinization surgery. Clinics in Plastic Surgery. 2018;45:323.
  7. Ferrando CA. Facial feminization surgery and facial gender confirmation surgery. In: Comprehensive Care of the Transgender Patient. Philadelphia, Pa.: Elsevier; 2020. Accessed April 22, 2019.


Products & Services