Print Mayo Clinic's approachPeople with advanced prostate cancer receive care from doctors at Mayo Clinic Comprehensive Cancer Center. Mayo Clinic Comprehensive Cancer Center is the only National Cancer Institute-designated comprehensive cancer center with three locations in Arizona, Florida and Minnesota. At Mayo Clinic, doctors and specialists work in multidisciplinary teams to address all your needs and explore all your options. Benefits of the team approach include: Expertise across all disciplines. Mayo Clinic doctors are highly skilled in all aspects of prostate cancer care and across every specialty involved in treating the condition. Collaboration. Mayo Clinic urologists, medical oncologists, radiation oncologists, nuclear medicine specialists, pathologists and radiologists rely on strong collaboration and multidisciplinary discussion to provide comprehensive care to each person with prostate cancer. Advanced diagnosis and treatmentMayo Clinic specialists have access to the latest diagnosis and treatment innovations to provide you with an accurate diagnosis and effective treatment plan. This includes: Detecting cancer recurrence sooner. Mayo Clinic was the first medical center to receive U.S. Food and Drug Administration approval to prepare and administer the choline C-11 PET scan, which helped doctors find prostate cancer recurrence sooner than other imaging available at the time. This innovation in prostate cancer imaging continues, as Mayo Clinic offers the latest tests, such as the PSMA PET scan. A full range of treatments to consider. Mayo Clinic doctors work with you to review all your treatment options and choose the treatment that suits your needs and goals. The range of treatments offered includes external beam radiation therapy, stereotactic body radiotherapy (SBRT), proton therapy, hormone therapy, targeted therapy, immunotherapy and radiopharmaceutical treatments. Access to the latest in clinical trials. Mayo Clinic doctors participate in clinical trials studying the latest treatments and new ways to use existing treatments. Taking part in a clinical trial may give you access to new medicines for metastatic castration-resistant prostate cancer (mCRPC). Talk with your healthcare team about which trials might be a good fit for you. Expertise and rankingsMayo Clinic doctors are widely respected for their experience and expertise in caring for people with prostate cancer. When you seek care at Mayo Clinic, you can expect: Experience you can trust. Each year, more than 23,000 people with prostate cancer receive care at Mayo Clinic. This experience means your care team is prepared with knowledge and resources to provide you with exactly the care you need. Center of excellence for radiopharmaceutical treatments. The Society of Nuclear Medicine and Molecular Imaging has designated Mayo Clinic as a Comprehensive Radiopharmaceutical Therapy Center of Excellence. This honor extends to the Mayo Clinic campuses in Arizona, Florida and Minnesota. Nationally recognized expertise. Mayo Clinic Comprehensive Cancer Center meets the strict standards for a National Cancer Institute-designated comprehensive cancer center. These standards recognize scientific excellence and a multispecialty approach focused on cancer prevention, diagnosis and treatment. Mayo Clinic Comprehensive Cancer Center is the only National Cancer Institute-designated comprehensive cancer center with three locations in Arizona, Florida and Minnesota. Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Jacksonville, Florida, and Mayo Clinic in Phoenix/Scottsdale, Arizona, are ranked among the Best Hospitals for cancer by U.S. News & World Report. Mayo Clinic in Rochester, Minnesota, is ranked as the top hospital in Minnesota and Mayo Clinic in Phoenix/Scottsdale, Arizona, is ranked as the top hospital in Arizona. Mayo Clinic's campus in Arizona Mayo Clinic's campus in Florida Mayo Clinic's campus in Minnesota Mayo Clinic Health System Mayo Clinic Healthcare, located in London More information about billing and insurance: Mayo Clinic in Arizona, Florida and Minnesota Mayo Clinic Health System Request an appointment Doctors & Departments Jan. 28, 2026 PrintShow references Prostate cancer. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=2&id=1459. Accessed Dec. 10, 2025. Prostate cancer treatment (PDQ) – Health professional version. https://www.cancer.gov/types/prostate/hp/prostate-treatment-pdq. Accessed Dec. 10, 2025. Partin AW, et al., eds. Prostate cancer. In: Campbell Walsh Wein Handbook of Urology. Elsevier; 2022. https://www.clinicalkey.com. Accessed Dec. 10, 2025. Treating prostate cancer. American Cancer Society. https://www.cancer.org/cancer/types/prostate-cancer/treating.html. Accessed Dec. 10, 2025. Garje R, et al. Systemic therapy in patients with metastatic castration-resistant prostate cancer: ASCO guideline update. Journal of Clinical Oncology. 2025; doi:10.1200/JCO-25-00007. Hussain A, et al. Chemotherapy in advanced castration-resistant prostate cancer. https://www.uptodate.com/contents/search. Accessed Dec. 10, 2025. Dmochowski RR, et al., eds. Campbell-Walsh-Wein Urology. 13th ed. Elsevier; 2026. https://www.clinicalkey.com. Accessed Dec. 10, 2025. Chemotherapy. American Cancer Society. https://www.cancer.org/cancer/managing-cancer/treatment-types/chemotherapy.html. Accessed Dec. 10, 2025. Medical review (expert opinion). Mayo Clinic. Dec. 2, 2025. Choline C 11 injection (approval letter). New Drug Application 203155. U.S. Food and Drug Administration. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=203155. Accessed April 4, 2025. Harris KM. Allscripts EPSi. Mayo Clinic. April 23, 2024. Become a comprehensive radiopharmaceutical therapy center of excellence. Society of Nuclear Medicine and Molecular Imaging. https://snmmi.org/Web/Clinical-Practice/Radiopharmaceutical-Therapy-Centers-of-Excellence/Become-a-Comprehensive-Radiopharmaceutical-Therapy-Center-of-Excellence.aspx. Accessed July 29, 2025. Tai HY, et al. Efficacy of cryotherapy in the prevention of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Supportive Care in Cancer. 2024; doi:10.1007/s00520-024-08680-3. Related Metastatic (stage 4) prostate cancer Prostate cancer Prostate cancer recurrence Chemotherapy for prostate cancerAboutDoctors&DepartmentsCare atMayoClinic PRC-20592988 Tests & Procedures Chemotherapy for prostate cancer