Calprotectin fecal test

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Mayo Clinic healthcare professionals and scientists study ways to improve care for people with digestive system conditions. This research includes inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. Researchers in the Enteric Neuroscience Program at each Mayo Clinic campus study how the nerves and muscles of the gastrointestinal tract work.

Mayo Clinic research teams work with specialists in oncology, pediatric hematology/oncology, and gastroenterology and hepatology. This team-based research helps support care for people who have calprotectin testing as part of diagnosis, treatment planning, monitoring or follow-up.

Publications

See a list of publications on the calprotectin test by Mayo Clinic authors on PubMed, a service of the National Library of Medicine.

Research Profiles

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By Mayo Clinic Staff
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Aug. 21, 2026
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  1. Calprotectin, feces (CALPR). Mayo Clinic Laboratories. https://www.mayocliniclabs.com/test-catalog/overview/63016. Accessed Aug. 10, 2026.
  2. Suttichaimongkol T, et al. Diagnostic performance of a fecal calprotectin assay as a biomarker for Mayo Endoscopic Subscore in ulcerative colitis: Result from a tertiary referral center. Inflammatory Bowel Diseases. 2024; doi:10.1093/ibd/izae005.
  3. Lacy BE, et al. ACG clinical guideline: Management of irritable bowel syndrome. American Journal of Gastroenterology. 2021; doi:10.14309/ajg.0000000000001036.
  4. AskMayoExpert. Diarrhea (adult). Mayo Clinic; 2025.
  5. Kozuch M, et al. The changes of fecal calprotectin and lactoferrin during Clostridioides difficile infection. Anaerobe. 2026; doi:10.1016/j.anaerobe.2026.103039.
  6. Chung RT, et al., eds. Colonic polyps and polyposis syndromes. In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 12th ed. Elsevier; 2026. https://www.clinicalkey.com. Accessed Aug. 10, 2026.
  7. Diarrhea. Merck Manual Professional Version. https://www.merckmanuals.com/professional/gastrointestinal-disorders/symptoms-of-gastrointestinal-disorders/diarrhea. Accessed Aug. 10, 2026.
  8. Health Education & Content Services. MC1335-07: Timed stool collection instructions for shipping returns. Mayo Clinic; 2026.
  9. Vasant DH, et al. British Society of Gastroenterology guidelines on the management of irritable bowel syndrome. Gut. 2021; doi:10.1136/gutjnl-2021-324598.
  10. Koninckx CR, et al. The use of fecal calprotectin testing in paediatric disorders: A position paper of the European Society for Paediatric Gastroenterology and Nutrition Gastroenterology Committee. Journal of Pediatric Gastroenterology and Nutrition. 2021; doi:10.1097/MPG.0000000000003046.
  11. Roca M, et al. Fecal calprotectin and eosinophil-derived neurotoxin in healthy children between 0 and 12 years. Journal of Pediatric Gastroenterology and Nutrition. 2017; doi:10.1097/MPG.0000000000001542.

Calprotectin fecal test