What you can expect By Mayo Clinic Staff Print Undergoing an autologous stem cell transplant involves: Taking medicines to raise the number of stem cells in your blood. You get medicines that cause you to have more stem cells. The medicines also move the cells out of your bone marrow and into your blood. From there, it's easy to harvest them. Harvesting stem cells from your blood. To get your stem cells, you have a needle put into a vein in your arm to draw blood. A machine filters out the stem cells. The rest of your blood goes back to your body. Your stem cells are then frozen and stored for later use. Getting high doses of cancer treatment. This is called conditioning. During this process, you get high doses of chemotherapy, radiation therapy or both to kill your cancer cells. The treatments you have depend on your condition. The cancer treatments used during the conditioning process carry a risk of side effects. Talk with your healthcare professional about what to expect from your treatment. Getting an infusion of stem cells. Your stem cells go back into your bloodstream through a vein. This is called an infusion. From your blood, the cells travel to your bone marrow. There, they begin making new blood cells. After your autologous stem cell transplant, you stay under close medical care. You meet with your care team often to watch for side effects and check your body's response to the transplant. Request an appointment Doctors & Departments Aug. 19, 2026 Print Show references Blood and marrow stem cell transplantation guide. Blood Cancer United. https://bloodcancerunited.org/resources/educational-resources/publications. Accessed May 7, 2026. Holmberg LA, et al. Determining eligibility for autologous hematopoietic cell transplantation. https://www.uptodate.come/contents/search. Accessed May 7, 2026. Blood cancer and diseases treated by transplants. National Marrow Donor Program. https://bethematch.org/transplant-basics/how-transplants-work/diseases-treatable-by-transplants. Accessed May 7, 2026. Stem cell therapy for MS. National Multiple Sclerosis Society. https://www.nationalmssociety.org/managing-ms/treating-ms/treatments-and-medications/ahsct. Accessed May 7, 2026. Types of stem cell or bone marrow transplant. American Cancer Society. https://www.cancer.org/cancer/managing-cancer/treatment-types/stem-cell-transplant/types-of-transplants.html. Accessed May 11, 2026. Autologous stem cell transplantAboutDoctors&Departments Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship Policy Opportunities Ad Choices Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. NEW: Mayo Clinic Guide to Better Sleep Listen to Health Matters Podcast Mayo Clinic on Incontinence The Essential Diabetes Book FREE Mayo Clinic Diet Assessment Mayo Clinic Health Letter - FREE book PRC-20202302 Tests & Procedures Autologous stem cell transplant