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Search Results 1-10 of 17 for Somatic
Special emphasis is on discovery and analysis of somatic variants — those originating in human cells during their life span — as they can cause cancer and various diseases.
These studies contribute to an improved understanding of the mechanisms that underlie the development of physical morbidity and disability in those with somatic symptom disorders.
Furthermore, iPSCs are generated using somatic cells from individual patients; they can be used for stem cell therapy with lower risks of rejection reactions.
From a detailed analysis of the breakpoints, it is clear that the translocations are frequently mediated by aberrant activity of B cell-specific mechanisms: somatic hypermutation and isotype switch recombination.
Additional drivers of lymphomagenesis include chromosomal copy number alterations (amplifications and deletions) and somatic mutations.
Focus areas Discovering inherited and somatic disease-causing structural mutations in AD and ALS.
Nowakowski is researching somatic mutations of BCL2, with the goal of selecting the appropriate therapies for specific patients.
Somatic mutation, copy number variation, epigenetic alteration and aberrant RNA splicing are common in human cancers.
Hickey and colleagues have pioneered the use of gene targeting and somatic cell nuclear transfer to develop large models of inborn errors of metabolism, including the first genetically engineered model of a liver disease — tyro...
., include the development of molecular genetic assays for the diagnosis, prognosis and treatment of solid tumors; clinical next-generation sequencing (NGS) technology for hereditary and somatic diseases; and molecular cytology and c...
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