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Search Results 1-10 of 31 for Somatic
SomaticSniper: Identification of somatic point mutations in whole genome sequencing data.
Special emphasis is on discovery and analysis of somatic variants — those originating in human cells during their life span — as they can cause cancer and various diseases.
These studies allow us to see how combinations of the somatic mutations in AL proteins drive amyloidogenicity.
Recently, somatic mutations in the histone H3 genes have been identified in the majority of high-grade pediatric glioma cases including DIPG; the predominant mutation leads to an amino acid change at lysine (K) 27 residue of H3.3 to ...
Additional drivers of lymphomagenesis include chromosomal copy number alterations (amplifications and deletions) and somatic mutations.
From a detailed analysis of the breakpoints, it is clear that the translocations are frequently mediated by aberrant activity of B cell-specific mechanisms: somatic hypermutation and isotype switch recombination.
These studies contribute to an improved understanding of the mechanisms that underlie the development of physical morbidity and disability in those with somatic symptom disorders.
Hickey and colleagues have pioneered the use of gene targeting and somatic cell nuclear transfer to develop large models of inborn errors of metabolism, including the first genetically engineered model of a liver disease — tyro...
Nowakowski is researching somatic mutations of BCL2, with the goal of selecting the appropriate therapies for specific patients.
Providing consults and training on a variety of topics, including rodent and zebrafish transgenic and knockout model development support; viral delivery of siRNA; transposons for somatic genetic engineering; and in vivo imaging.
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