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Search Results 1-10 of 34 for Somatic
Special emphasis is on discovery and analysis of somatic variants — those originating in human cells during their life span — as they can cause cancer and various diseases.
Specifically, raw somatic variants were quality filtered based on the allelic and overall depth of coverage (6), fraction of alternative allele (0.1), base quality (20), average mapping quality (20), proximity to homopolymer runs (8)...
These studies allow us to see how combinations of the somatic mutations in AL proteins drive amyloidogenicity.
Recently, somatic mutations in the histone H3 genes have been identified in the majority of high-grade pediatric glioma cases including DIPG; the predominant mutation leads to an amino acid change at lysine (K) 27 residue of H3.3 to ...
All CRCs in the Catalog of Somatic Mutations in Cancer (COSMIC) database were queried.
These studies contribute to an improved understanding of the mechanisms that underlie the development of physical morbidity and disability in those with somatic symptom disorders.
Furthermore, iPSCs are generated using somatic cells from individual patients; they can be used for stem cell therapy with lower risks of rejection reactions.
From a detailed analysis of the breakpoints, it is clear that the translocations are frequently mediated by aberrant activity of B cell-specific mechanisms: somatic hypermutation and isotype switch recombination.
Additional drivers of lymphomagenesis include chromosomal copy number alterations (amplifications and deletions) and somatic mutations.
Focus areas Discovering inherited and somatic disease-causing structural mutations in AD and ALS.
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