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Search Results 1-9 of 9 for Proto-oncogene
Oncogene dysregulation in lymphoma.
Specifically, we are interested in the role of epidermal growth factor receptor (EGFR), a frequently mutated oncogene in gliomas, and its effect on the expression of effector molecules (integrins and proteinases) that drive tumor inv...
Current studies are focused on developing genetically engineered preclinical models of PKCι-driven cancer in order to define the specific molecular mechanisms by which this oncogene drives tumorigenesis, and to evaluate novel th...
A current focus is on the MYC oncogene that appears in some patients to cause the progression of MGUS to myeloma.
In pancreatic cancer, the oncogene KRas contributes to a metabolic rewiring of tumor cells.
Discoveries from the Copland laboratory include RhoB, transforming growth factor receptor 3 (TBR3) and GATA3 as tumor suppressor genes in addition to FOXO3a, stearoyl CoA desaturase 1 (SCD1), neuronal pentraxin 2 (NPTX2) and others as novel oncogenes...
Over-expression of MUC1 in the mouse mammary gland results in tumor formation, indicating that MUC1 is an oncogene.
A major subtype accounting for 30 percent of lung cancer diagnoses, LSCC is characterized by poor therapeutic response, a high relapse rate, poor prognosis and a lack of actionable oncogene targets.
Galardy's laboratory demonstrated that this enzyme is in fact an oncogene that drives the development of lung tumors and B-cell cancers (lymphoma and plasma cell tumors) and is required for the ongoing survival of cancers in which it...
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