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Search Results 1-10 of 12 for Paracrine
Recent evidence suggests that the beneficial effects of stem cells in suppressing inflammation are largely due to paracrine effects mediated by extracellular vesicles.
Researchers in the lab are interested in creating liver-on-chip devices to study paracrine signals being exchanged between liver cell compartments during injury.
She is interested in optimization of stem cell function using hypoxia preconditioning and further studying its effects on paracrine mechanisms of mesenchymal stem cell-derived extracellular vesicles.
This project focuses on understanding how epigenetic dysregulation in cholangiocytes leads to the release of paracrine molecules that subsequently activate myofibroblasts.
Additionally, interests include investigating local "paracrine effects" in the breast that may point to specific mechanisms in the hormonal-inflammatory axis and potentially can be inhibited with medications.
Functionally, IL-1beta has potent osteoclast activating factor activity, can increase the expression of adhesion molecules, and can induce paracrine IL-6 production.
Human mesenchymal cells have built-in mesodermal multipotency to induce cardiac regeneration by inducing paracrine signaling, differentiation into new cardiomyocytes and activation of endogenous cardiac stem cells.
Serotonin is an important neurotransmitter and paracrine messenger in the gastrointestinal tract that plays a critical role in regulating gastrointestinal physiology in health and disease.
When communication is permitted, the injured cellular compartment is allowed to exchange paracrine signals with uninjured cells.
Since it is increasingly apparent that stem cell benefit is likely due to a paracrine mechanism of action, rather than direct integration, acellular approaches are of increasing interest.
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