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In these applications, the hydrophilic PEG molecule is cross-linked to a therapeutic agent to "shield" or reduce interactions of it with proteins and cells that would normally decrease the therapeutics' interactions with its target.
The pump is shown in the autoinhibited state, in which the calmodulin-binding domain (CaM-BD) binds to intramolecular sites on the first and second hydrophilic loops.
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