Search Results 591-600 of 37895 for Two-phase

  1. A Study to Assess the Safety and Tolerability of CFT8634 in Locally Advanced or Metastatic SMARCB1-Perturbed Cancers, Including Synovial Sarcoma and SMARCB1-Null Tumors - Mayo Clinic

    Phase 2 only: To assess preliminary antitumor activity by overall response rate (ORR) as measured by Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 ...

  2. A Study Of BH-30643 In Subjects With Locally Advanced Or Metastatic NSCLC Harboring EGFR And/or HER2 Mutations - Mayo Clinic

    Phase 2 will further evaluate the antitumor efficacy and safety in specified cohorts determined by EGFR/HER2 mutation subtypes and/or treatment history at the ...

  3. Breast Cancer Clinical Trials - Mayo Clinic Research

    The purpose of this study is to determine the recommended Phase 2 dose twice weekly of berzosertib administered concurrently with conventionally ...

  4. PF-04449913 Single-Agent In Patients with Myelofibrosis Previously Treated with a Janus Kinase Inhibitor - Mayo Clinic

    Following the lead-in, a phase 2, randomized, double blind, 2 arm study of oral single agent PF 04449913 versus placebo will be tested in patients resistant or ...

  5. A Study to Evaluate the Safety, Pharmacokinetics, and Preliminary Effectiveness of Isatuximab in Patients Awaiting Kidney Transplantation - Mayo Clinic

    The primary purpose of this study in Phase 2 is to evaluate the effectiveness of isatuximab in desensitization of patients awaiting kidney transplantation.

  6. Epicardial Delivery Of XC001 Gene Therapy To Promote Angiogenesis In CAD Patients Undergoing Treatment With CABG - Mayo Clinic

    This is a 26-week (with a 26-week extension) multicenter, randomized, double-blind, placebo-controlled Phase 2 study of XC001 versus placebo. Approximately ...

  7. Publications - Yixiu Kang, Ph.D. - Mayo Clinic

    ... phase 2 trial. Lancet Oncol. 2023 Oct; 24 (10):1083-1093 Epub 2023 Sept 08 ... Technical Note: Comprehensive evaluation and implementation of two independent ...

  8. A Study of JNJ-69086420, an Actinium-225-Labeled Antibody Targeting Human Kallikrein-2 (hK2) for Advanced Prostate Cancer - Mayo Clinic

    The purpose of this study is to determine the recommended Phase 2 dose(s) (RP2D\[s\]) of JNJ-69086420 in Part 1 (Dose Escalation) and to determine safety and ...

  9. Hodgkin Lymphoma (Hodgkin Disease) Clinical Trials - Mayo Clinic Research

    It is an open-label, 2-stage study designed to determine the recommended dose level of bendamustine in combination with brentuximab vedotin. The study will ...

  10. Phase ll Study of Pirfenidone in Patients With RAILD - Mayo Clinic

    Study phase. 2. During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase ...