With aging, senescent cells accumulate in the bone microenvironment where they promote osteoclastogenesis and inhibit osteoblastogenesis. Senolytic therapy alleviates these effects by eliminating senescent cells, which in turn reduces bone resorption and either maintains (trabecular sites) or enhances (cortical sites) bone formation due to uncoupling between osteoclasts and osteoblasts. Based on Nature Medicine.
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