Otorrinolaringología (ENT)/cirugía de cabeza y cuello

A continuación se enumeran ensayos clínicos actuales.

Filtrar esta lista de estudios según la ubicación, el estado del estudio y más.

1. A Study to Determine the Feasibility of Doppler Ultrasound of Large Arterial Systems of the Brain as Vascular Involvement Markers in Presbyacusis and Presbyvestibulopathy

   Jacksonville, Fla.

   The purpose of this study is to benchmark the feasibility of carotid artery biomechanical analysis and vertebral-basilar Transcranial Doppler (TCD) as markers of vascular involvement in presbyacusis and presbyvestibulopathy.

2. A Study to Examine Proteins from Chronic Otitis Media Fluid Samples in Patients undergoing Myringotomy and Possibly a Tube Insertion Procedure

   Scottsdale/Phoenix, Ariz., Rochester, Minn.

   During myringotomy and possibly a tube insertion procedure a small amount of fluid that is being removed from the middle ear (whether or not you participate in the study) will be examined for different proteins or it may be saved and used for future research studies.

3. A Study to Evaluate Electrophysiological Measurements in Cochlear Implant Patients

   Rochester, Minn.

   The purpose of this study is to perform electrophysiological (inner ear) measurements to assess hearing function in cochlear implant patients.

    

    

4. ESSBS Quality of Life

   Rochester, Minn.

   The purpose of this study is to:

   • Measure the short and long-term overall and nasal-specific quality of life (QOL) impact of patients undergoing Endoscopic Endonasal Skull Base Surgery (EESBS) for pituitary and sellar lesions
   • Determine the relative difference in QOL impact of EESBS for patients undergoing surgery for functional and nonfunctional pituitary adenomas
   • Generate baseline data to development and validate a sitespecific endoscopic-specific comprehensive QOL for EESBS

5. Randomized Phase II/III Trial of Adjuvant Radiation Therapy with Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck

   Rochester, Minn.

   This randomized phase II/III trial studies how well radiation therapy works when given together with cisplatin compared to docetaxel or cetuximab and docetaxel after surgery in treating patients with stage III-IV squamous cell head and neck cancer. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or transmit tumor killing molecules to them. It is not yet known whether radiation therapy is more effective when given with cisplatin, docetaxel, or cetuximab and docetaxel.

6. A Study Identifying Blood Serum Markers of the Immune System Affecting Different Features of Chronic Rhinosinusitis

   Rochester, Minn.

   The purpose of this study is to find out what immune system processes cause the chronic inflammation that happens with chronic rhinosinusitis (CRS) and if there are different immune system pathways involved among CRS patients.

7. Otorhinolaryngology Normal, Tumor Tissue, Saliva, Stool, and Blood Bank

   Rochester, Minn.

   The purpose of this study is to obtain tissue, blood, saliva, and stool specimens and informed consent from ENT patients in order to build a freezer archive of samples to support ongoing and future developmental studies.

8. A Trial to Evaluate the Safety of GEN1046 in Patients with Malignant Solid Tumors

   Scottsdale/Phoenix, Ariz., Rochester, Minn., Jacksonville, Fla.

   The purpose of this trial is to evaluate the safety of GEN1046 in patients with malignant solid tumors.

9. A Study of Pain Control Following Sinus Surgery

   Rochester, Minn.

   The purpose of this study is to determine the degree to which pain following ESS can be adequately controlled by non-opioid medications. It will also determine whether post-ESS narcotic use can be avoided entirely, or at least significantly limited.  The results of this study will help to develop a standardized approach to pain management in the post-ESS setting and help to clarify the role of non-opioid pain medications. The ultimate goal would be to positively affect opioid prescribing patterns among surgeons who perform ESS in order to significantly reduce the quantity of opioids prescribed to patients while continuing to adequately manage patients' pain.

    

    

10. Study of the Preceptis Medical Inc. Hummingbird™ Tympanostomy Tube System in the Otolaryngology Clinic

    Rochester, Minn.

    The objective of this study is to evaluate the safety and performance of the H-TTS for the placement of ear tubes in patients undergoing tympanostomy tube placement in an otolaryngology clinic using local anesthetic.