耳鼻喉科 (ENT) /头颈外科

以下为当前的临床试验。

按院区、状态和其他条件筛选该研究列表。

1. A Study to Examine Proteins from Chronic Otitis Media Fluid Samples in Patients undergoing Myringotomy and Possibly a Tube Insertion Procedure

   Scottsdale/Phoenix, Ariz., Rochester, Minn.

   During myringotomy and possibly a tube insertion procedure a small amount of fluid that is being removed from the middle ear (whether or not you participate in the study) will be examined for different proteins or it may be saved and used for future research studies.

2. A Study to Evaluate Electrophysiological Measurements in Cochlear Implant Patients

   Rochester, Minn.

   The purpose of this study is to perform electrophysiological (inner ear) measurements to assess hearing function in cochlear implant patients.

    

    

3. A Study to Develop a Vestibular and Balance Function Measure (VBFM) Tool

   Rochester, Minn.

   The purpose of this study is develop a tool called the Vestibular and Balance Function Measure (VBFM) to evaluate vertigo, dizziness, or balance problems that affect patients; ability to perform tasks and participate in activities.

4. A Study of Factors That Predispose, Promote, and Perpetuate Post-Traumatic Dizziness

   Rochester, Minn.

   The purpose of this study is to investigate whether recent, groundbreaking discoveries about key pathophysiologic processes that drive chronic dizziness in patients without traumatic brain injury (TBI9,10) are applicable to patients with post-mTBI vestibular disability. We expect the results of this project to have practical clinical and research applications, providing novel data for two future steps:

5. A Study to Evaluate Endoscopic Endonasal Skull Base Surgery and Pituitary Surgery Quality of Life

   Rochester, Minn.

   The objectives of this study are to:

   • • Measure the short and long-term overall and nasal-specific quality of life (QOL) impact of patients undergoing Endoscopic Endonasal Skull Base Surgery (EESBS) for pituitary and sellar lesions.
     • Determine the relative difference in QOL impact of EESBS for patients undergoing surgery for functional and nonfunctional pituitary adenomas.
     • Generate baseline data to development and validate a site-specific endoscopic-specific comprehensive QOL for EESBS.
     • Particular tumors of interest include pituitary tumors, Rathke’s cleft cysts, craniopharyngiomas, clival chordomas and chondrosarcomas.
     • Specific QOL aims focus on olfaction (sense of smell), gustation (sense of taste) and nasal function.

    

    

6. Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Evidence of Antitumor Activity of JAB-3312 Based Combination Therapies in Adult Patients with Advanced Solid Tumors

   Jacksonville, Fla., Rochester, Minn., Scottsdale/Phoenix, Ariz.

   The purpose of this study is to demonstrate the safety and tolerability of JAB-3312 in combination with anti-PD-1 mAb or MEKi or KRASi or EGFR-TKI in patients with advanced solid tumors.

7. Randomized Phase II/III Trial of Adjuvant Radiation Therapy with Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck

   Rochester, Minn.

   This randomized phase II/III trial studies how well radiation therapy works when given together with cisplatin compared to docetaxel or cetuximab and docetaxel after surgery in treating patients with stage III-IV squamous cell head and neck cancer. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or transmit tumor killing molecules to them. It is not yet known whether radiation therapy is more effective when given with cisplatin, docetaxel, or cetuximab and docetaxel.

8. A Study to Evaluate the Otonexus Ultrasound Otoscope

   Rochester, Minn.

   The purpose of this study is to evaluate usability of the OtoNexus device when used in pediatric and adult patients in a clinical setting to detect middle ear effusion, and to determine if it is viral, bacterial, or mucoid.

    

    

9. Study of the Preceptis Medical Inc. Hummingbird™ Tympanostomy Tube System in the Otolaryngology Clinic

   Rochester, Minn.

   The objective of this study is to evaluate the safety and performance of the H-TTS for the placement of ear tubes in patients undergoing tympanostomy tube placement in an otolaryngology clinic using local anesthetic.

10. Neurological Diseases Co-existing in Patients with Spasmotic Dsyphonia (SD)

    Jacksonville, Fla.

    The purpose of this study is to investigate if spasmotic dsyphonia (SD) patients have neurological diseases like dystonia, cervical dystonia, Parkinson’s disease more than normal population