Terlipressin (intravenous route)

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies have not been performed on the relationship of age to the effects of terlipressin injection in the pediatric population. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of terlipressin injection in the elderly. However, elderly patients are more sensitive to the effects of this medicine than younger adults.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Heart attack or stroke, history of or
• Heart or blood vessel disease (eg, cardiac, peripheral, or mesenteric ischemia), or history of or
• Hypervolemia (fluid overload) or
• Hypoxia (low oxygen in the blood) or
• Liver disease (eg, acute on chronic liver failure), severe or
• Lung or breathing problems, worsening of—Should not be used in patients with these conditions.

• Liver transplant—This medicine may make you ineligible for liver transplant because of its side effects (eg, respiratory failure, ischemia). Talk to your doctor if you have concerns.

More common

• Blue lips, fingernails, or skin
• chest pain or discomfort
• chills
• confusion
• decrease in amount of urine
• difficult or trouble breathing
• fast heartbeat
• fever
• irregular, fast or slow, or shallow breathing
• lightheadedness, dizziness or fainting
• slow or irregular heartbeat
• swelling of the fingers, hands, feet, or lower legs
• unusual tiredness
• weight gain

Less common

• Constipation
• diarrhea
• headache
• itching skin
• nausea
• numbness and tingling of the face, fingers, or toes
• pain in the arms, legs, or lower back, especially pain in the calves or heels upon exertion
• pain or discomfort in the arms, jaw, back, or neck
• pale, bluish-colored, or cold hands or feet
• severe numbness, especially on one side of the face or body
• stomach pain, usually after eating a meal
• sweating
• vomiting
• weak or absent pulses in the legs

Incidence not known

• Blue-green to black skin discoloration
• coma
• decreased urine output
• increased thirst
• muscle pain or cramps
• pain, redness, or sloughing of the skin at the place of injection
• seizures
• sores on the skin, especially on the thighs, breasts, penis, or buttocks
• swelling of the face, ankles, or hands