Streptokinase (intravenous route, intracoronary route)

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies have not been performed on the relationship of age to the effects of streptokinase in the pediatric population. Safety and efficacy have not been established .

No information is available on the relationship of age to the effects of streptokinase in geriatric patients .

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Defibrotide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acenocoumarol
• Alteplase, Recombinant
• Anistreplase
• Apixaban
• Ardeparin
• Argatroban
• Bemiparin
• Betrixaban
• Bivalirudin
• Certoparin
• Dabigatran Etexilate
• Dalteparin
• Danaparoid
• Desirudin
• Dipyridamole
• Edoxaban
• Enoxaparin
• Fondaparinux
• Heparin
• Lepirudin
• Nadroparin
• Parnaparin
• Pentosan Polysulfate Sodium
• Phenindione
• Phenprocoumon
• Protein C
• Reteplase, Recombinant
• Reviparin
• Rivaroxaban
• Tenecteplase
• Ticagrelor
• Tinzaparin
• Urokinase
• Warfarin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aspirin

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Bleeding problems or a history of bleeding in any part of the body or
• Blood clotting disorder, uncontrolled or
• Brain disease or tumor or
• High blood pressure, uncontrolled or
• Stroke, recent (within two months) or
• Surgery or injury to the brain or spine, recent (within two months)—This medicine should NOT be used in these conditions .

• Catheter (tube) infection or
• Diabetes mellitus, uncontrolled or
• Eye problems from diabetes (e.g., hemorrhagic retinopathy) or high blood pressure or
• Heart disease or infections (e.g., mitral stenosis or endocarditis) or
• Injections into a blood vessel or
• Kidney disease, severe or
• Liver disease, severe or
• Lung disease (e.g., tuberculosis or severe bronchitis) or
• Pancreatitis or
• Placement of any tube into the body or
• Surgery or injury of any kind, major and recent—The chance of serious bleeding may be increased .

• Heart rhythm problems or
• Hypotension—These conditions may get worse .

• Streptococcal infection, recent (within 6 months) (e.g., sore throat, rheumatic fever)—This medicine may not be effective .

More common

• Blurred vision
• confusion
• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• fever
• sweating
• unusual tiredness or weakness

Less common

• Blood in stool
• blood in urine
• nose bleeds
• red or purple spots on skin
• unusual bruising
• vomiting blood

Rare

• Abdominal pain or swelling
• back pain or backaches
• black, tarry stools
• burning, itching, redness, or soreness of skin
• cloudy urine
• cold clammy skin
• constipation
• cough
• coughing up blood
• difficulty with breathing
• difficulty with swallowing
• dizziness
• fast heartbeat
• fast, weak pulse
• feeling of warmth
• greatly decreased frequency of urination or amount of urine
• headaches
• hives or welts
• large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• lightheadedness
• muscle or bone pain
• nausea and vomiting
• noisy breathing
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• redness of the face, neck, arms, and occasionally, upper chest
• shortness of breath
• skin rash
• tightness in chest
• wheezing