Description and Brand Names

Drug information provided by: IBM Micromedex

US Brand Name

  1. Opdivo

Descriptions


Nivolumab injection is used alone or together with other medicines (eg, ipilimumab) to treat melanoma (skin cancer) that has spread throughout the body (metastatic) or that cannot be removed by surgery. It is also used to help prevent melanoma from coming back after it and lymph nodes that contain cancer have been removed by surgery.

Nivolumab injection is also used with ipilimumab as first-line treatment for metastatic (cancer that has already spread) non-small cell lung cancer (NSCLC) in patients whose tumors express PD-L1 and do not have an abnormal EGFR or ALK gene. Your doctor will perform a test to check for the PD-L1 tumor before you receive this medicine.

It is also used with ipilimumab and 2 cycles of medicines containing platinum as first-line treatment for non-small cell lung cancer that has come back or spread in patients whose tumors do not have an abnormal EGFR or ALK gene.

Nivolumab injection is also used to treat non-small cell lung cancer that has spread throughout the body and after other cancer medicines (eg, medicines containing platinum) have been tried but did not work well. It is given to patients whose tumors have an abnormal EGFR or ALK gene and have tried treatment for these tumors but did not work well.

This medicine is also used to treat small cell lung cancer that has spread throughout the body and after at least two different kinds of cancer medicines have been tried but did not work well.

Nivolumab injection is used alone to treat kidney cancer that has spread throughout the body in patients who have received other medicines. It is also used together with ipilimumab to treat kidney cancer that has spread throughout the body in patients who have not received other medicines.

It is also used to treat classical Hodgkin lymphoma (white blood cell cancer) that has come back or spread after autologous hematopoietic stem cell transplantation (HSCT) and used brentuximab vedotin after stem cell transplant, or after you received at least 3 kinds of treatment including autologous HSCT.

This medicine is also used to treat squamous cell cancer of the head and neck (SCCHN) that has come back or spread throughout the body after receiving medicines containing platinum but did not work well.

It is also used to treat patients with urothelial cancer (bladder cancer) that has spread or grown and have tried cancer medicines containing platinum but did not work well.

Nivolumab injection is also used alone or together with other medicines (eg, ipilimumab) to treat microsatellite instability high (MSI-H) or mismatch repair deficient (dMMR) colorectal cancer (cancer of the colon or rectum) that has spread. It is given to patients who have received other cancer treatments (eg, fluoropyrimidine, oxaliplatin, irinotecan) that did not work well.

Nivolumab injection is also used alone or together with other medicines (eg, ipilimumab) to treat hepatocellular cancer (liver cancer) in patients who have received other medicines (eg, sorafenib).

This medicine is also used to treat squamous cell carcinoma of the esophagus that has returned, spread, or cannot be removed by surgery in patients who have received other medicines (eg, fluoropyrimidine, platinum).

Nivolumab is a monoclonal antibody that affects the immune system and helps control the growth of cancer cells.

This medicine is to be given only by or under the supervision of your doctor.

This product is available in the following dosage forms:

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