Morphine (injection route)


    Brand Name

    US Brand Name

    Astramorph PF

    Duramorph

    Infumorph


    Description

    Morphine injection is used to treat pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated. It may also be used before or during surgery with an anesthetic (medicine that puts you to sleep). Morphine belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain.

    When a narcotic medicine is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.

    This medicine is to be given only by or under the immediate supervision of your doctor.

    This product is available in the following dosage forms:

    • Solution

    Before Using

    In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

    Allergies

    Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

    Pediatric

    Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of morphine injection in children 1 month of age and older. Safety and efficacy in infants younger than 1 month of age have not been established.

    Appropriate studies have not been performed on the relationship of age to the effects of morphine injection in the pediatric population. Safety and efficacy have not been established. Use of morphine epidural injection is not recommended in children.

    Geriatric

    Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of morphine injection in the elderly. However, elderly patients are more likely to have age-related kidney, heart, liver, or lung problems, which may require caution and an adjustment in the dose for patients receiving morphine injection.

    Breastfeeding

    There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

    Drug Interactions

    Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

    Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

    • Isocarboxazid
    • Linezolid
    • Methylene Blue
    • Naltrexone
    • Ozanimod
    • Phenelzine
    • Procarbazine
    • Rasagiline
    • Safinamide
    • Samidorphan
    • Selegiline
    • Tranylcypromine

    Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

    • Abrocitinib
    • Acepromazine
    • Aclidinium
    • Adagrasib
    • Alfentanil
    • Almotriptan
    • Alogliptin
    • Alprazolam
    • Alvimopan
    • Amantadine
    • Amifampridine
    • Amiloride
    • Amineptine
    • Amiodarone
    • Amitriptyline
    • Amitriptylinoxide
    • Amobarbital
    • Amoxapine
    • Amphetamine
    • Anileridine
    • Aripiprazole
    • Aripiprazole Lauroxil
    • Asenapine
    • Asunaprevir
    • Atorvastatin
    • Atropine
    • Azithromycin
    • Baclofen
    • Belladonna
    • Bemetizide
    • Bendroflumethiazide
    • Benperidol
    • Bentazepam
    • Benzhydrocodone
    • Benzphetamine
    • Benzthiazide
    • Benztropine
    • Berotralstat
    • Biperiden
    • Boceprevir

    Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

    • Esmolol
    • Somatostatin
    • Yohimbine

    Other Interactions

    Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

    Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

    • Ethanol

    Other Medical Problems

    The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

    • Addison's disease (adrenal gland problem) or
    • Alcohol abuse, or history of or
    • Asthma, severe or
    • Brain tumor or
    • Breathing problems, severe (e.g., hypoxia) or
    • Chronic obstructive pulmonary disease (COPD) or
    • Cor pulmonale (serious heart condition) or
    • Drug dependence, especially with narcotics, or history of or
    • Enlarged prostate (BPH, prostatic hypertrophy) or
    • Gallbladder disease or gallstones or
    • Head injuries, history of or
    • Heart disease or
    • Hypothyroidism (an underactive thyroid) or
    • Hypovolemia (low blood volume) or
    • Increased pressure in the head or
    • Kyphoscoliosis (curvature of the spine with breathing problems) or
    • Problems with passing urine or
    • Respiratory depression (very slow breathing) or
    • Ulcerative colitis—Use with caution. May increase risk for more serious side effects.
    • Asthma, acute or severe or
    • Heart failure from lung disease or
    • Heart rhythm problems (eg, atrial flutter, tachycardia) or
    • Lung or breathing problems, severe or
    • Stomach or bowel blockage (eg, paralytic ileus)—Should not be used in patients with these conditions.
    • Heart attack or
    • Hypotension (low blood pressure) or
    • Seizures, history of—Use with caution. May make these conditions worse.
    • Kidney disease or
    • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

    Proper Use

    A nurse or other trained health professional will give you this medicine in a hospital. This medicine may be given as a shot under the skin, as a shot into one of your muscles, or through an IV catheter placed in one of your veins. It can also be given through a needle or catheter into your back.

    Your doctor will give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.


    Precautions

    It is very important that your doctor check the progress of you or your child while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it. Blood and urine tests may be needed to check for unwanted effects.

    Do not use this medicine if you are using or have used an MAO inhibitor (MAOI) such as isocarboxazid [Marplan®], linezolid [Zyvox®], phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]) within the past 14 days.

    Check with your doctor before using this medicine with alcohol or other medicines that affect the central nervous system (CNS). The use of alcohol or other medicines may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping. Some examples of medicines that affect the CNS are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicines, medicine for depression, medicine for anxiety, prescription pain medicine or narcotics, medicine for attention deficit and hyperactivity disorder, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics.

    This medicine may cause sleep-related breathing problems (eg, sleep apnea, sleep-related hypoxemia). Your doctor may decrease your dose if you have sleep apnea while using this medicine.

    Using this medicine while you are pregnant may cause neonatal withdrawal syndrome in your newborn baby. Check with your doctor right away if your baby has an abnormal sleep pattern, diarrhea, a high-pitched cry, irritability, shakiness or tremors, weight loss, vomiting, or fails to gain weight. Tell your doctor right away if you think you are pregnant or if you plan to become pregnant while using this medicine.

    Call your doctor right away if you have worsening of pain, increased sensitivity to pain, or new pain after taking this medicine. These may be symptoms of opioid-induced hyperalgesia and allodynia.

    This medicine may be habit-forming. If you or your child feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.

    Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you or your child to take laxatives, drink a lot of fluids, or increase the amount of fiber in the diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.

    This medicine may cause adrenal gland problems. Check with your doctor right away if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting.

    Dizziness, lightheadedness, or fainting may occur when you or your child get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Also, lying down for a while may relieve the dizziness or lightheadedness.

    This medicine may make you dizzy, drowsy, confused, or disoriented. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

    Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you or your child are using this medicine. Serious unwanted effects can occur if certain medicines are given together with morphine injection.

    If you or your child have been using this medicine regularly for several weeks or longer, do not suddenly stop using it without checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent worsening of your condition and reduce the possibility of withdrawal symptoms, including stomach cramps, anxiety, fever, nausea, runny nose, sweating, tremors, or trouble with sleeping.

    Check with your doctor right away if you or your child have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body.

    Using too much of this medicine may cause infertility (unable to have children). Talk with your doctor before using this medicine if you plan to have children.

    Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.


    Side Effects

    Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

    Check with your doctor or nurse immediately if any of the following side effects occur:

    More common

    • Difficult or trouble breathing
    • irregular, fast or slow, or shallow breathing
    • pale or blue lips, fingernails, or skin
    • very slow breathing

    Incidence not known

    • Agitation
    • blurred vision
    • chest tightness
    • confusion
    • cough
    • darkening of the skin
    • decrease in frequency of urination
    • decrease in the amount of urine
    • diarrhea
    • difficulty in passing urine (dribbling)
    • difficulty swallowing
    • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    • fever
    • increased sensitivity to pain
    • loss of appetite
    • mental depression
    • nausea
    • overactive reflexes
    • painful urination
    • poor coordination
    • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    • seizures
    • shivering
    • sweating
    • talking or acting with excitement you cannot control
    • trembling or shaking
    • twitching
    • unusual tiredness or weakness
    • worsening of pain

    Get emergency help immediately if any of the following symptoms of overdose occur:

    Symptoms of overdose

    • Change in consciousness
    • decreased awareness or responsiveness
    • difficulty with breathing
    • irregular, fast or slow, or shallow breathing
    • lack of muscle tone
    • lightheadedness
    • loss of consciousness
    • pale or blue lips, fingernails, or skin
    • pinpointed pupils of the eyes
    • severe sleepiness
    • slow or irregular heartbeat
    • trouble breathing
    • unusual tiredness

    Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

    Incidence not known

    • Absent, missed, or irregular menstrual periods
    • anxiety
    • decreased interest in sexual intercourse
    • delusions
    • depersonalization
    • difficulty having a bowel movement (stool)
    • false or unusual sense of well-being
    • hallucinations
    • headache
    • inability to have or keep an erection
    • itching skin
    • loss in sexual ability, desire, drive, or performance
    • menstrual changes
    • stopping of menstrual bleeding

    Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

    Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.






    CON-XXXXXXXX

    Make an impact on medicine!

    At Mayo Clinic, our benefactors play a crucial role in our work. Make a gift today to discover more cures and save more lives.