Iberdomide (oral route)

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Female patients should take necessary precautions to avoid pregnancy while taking iberdomide. Begin 2 forms of effective birth control together 4 weeks before starting treatment, during treatment, even if the dose is stopped for a short time, and for at least 4 weeks after your last dose. Talk to your doctor about the most effective forms of birth control for you and your partner. Call your doctor right away if you think you are pregnant.

Female patients who can get pregnant must have 2 negative pregnancy tests before starting treatment with this medicine. Pregnancy tests may be done weekly for the first month during treatment, and then every 2 weeks if your menstrual cycle is not regular or every 4 weeks if your menstrual cycle is regular.

Males who are sexually active must protect their female partner from getting pregnant. Iberdomide will appear in the semen of male patients. If you are sexually active, you must use a latex or synthetic condom every time you have sex with a female who could get pregnant. If you have had a vasectomy, you still have to use a latex condom during sex. You must continue to use a condom during treatment, even if the dose is stopped for a short time, and for at least 4 weeks after your last dose. Call your doctor right away if you think your sexual partner may be pregnant.

Do not donate blood, eggs, or sperm while you are taking this medicine and for at least 4 weeks after your last dose.

This medicine may increase your risk of having blood clots, a heart attack, or stroke. Check with your doctor right away if you have anxiety, chest pain, confusion, difficulty with speaking, dizziness or lightheadedness, double vision, fainting, fast heartbeat, inability to move the arms, legs, or facial muscles, leg pain or swelling, slow speech, or trouble breathing.

Iberdomide can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

• If you can, avoid people with infections. Check with your doctor right away if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
• Check with your doctor right away if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.
• Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.
• Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
• Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.
• Avoid contact sports or other situations where bruising or injury could occur.

This medicine may cause serious infections. Check with your doctor right away if you have fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.

This medicine may increase the risk of secondary cancers. Talk to your doctor if you have concerns about this.

Some men and women who use this medicine have become infertile (unable to have children). Talk with your doctor before using this medicine if you plan to have children.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.