Description
Fludarabine injection belongs to the group of medicines called antimetabolites. It is used to treat a type of cancer of the white blood cells called B-cell chronic lymphocytic leukemia (CLL). This medicine is used in patients with CLL who have already been treated with an alkylating agent (e.g., bendamustine) that did not work well. .
Fludarabine injection interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by fludarabine injection, other effects may also occur. Some of these may be serious and must be reported to your doctor. Other effects may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.
Before you begin treatment with fludarabine injection, you and your doctor should talk about the good this medicine will do as well as the risks of using it.
Fludarabine injection is to be administered only by or under the immediate supervision of your doctor.
This product is available in the following dosage forms:
- Powder for Solution
- Solution
Before Using
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of fludarabine injection in the pediatric population. Safety and efficacy have not been established.
Geriatric
No information is available on the relationship of age to the effects of fludarabine injection in geriatric patients.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Measles Virus Vaccine, Live
- Mumps Virus Vaccine, Live
- Rotavirus Vaccine, Live
- Rubella Virus Vaccine, Live
- Varicella Virus Vaccine, Live
- Zoster Vaccine, Live
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Adenovirus Vaccine Type 4, Live
- Adenovirus Vaccine Type 7, Live
- Bacillus of Calmette and Guerin Vaccine, Live
- Cholera Vaccine, Live
- Dengue Tetravalent Vaccine, Live
- Ebola Zaire Vaccine, Live
- Influenza Virus Vaccine, Live
- Pentostatin
- Poliovirus Vaccine, Live
- Smallpox Monkeypox Vaccine, Live Non-Replicating
- Smallpox Vaccine
- Typhoid Vaccine, Live
- Yellow Fever Vaccine
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Bone marrow problems (e.g., anemia, neutropenia, or thrombocytopenia)—Fludarabine injection may worsen these conditions.
- Chickenpox (including recent exposure) or
- Herpes zoster (shingles)—Risk of severe disease affecting other parts of the body.
- Gout (history of) or
- Kidney stones (history of)—Fludarabine may increase levels of uric acid in the body, which can cause gout or kidney stones.
- Infection—Fludarabine injection may decrease your body's ability to fight infection.
- Kidney disease—Use with caution. Effects of fludarabine injection may be increased because of slower removal of the medicine from the body.
- Transfusions—Non-irradiated blood transfusion may increase the risk of side effects of fludarabine injection.
Proper Use
This medicine may cause nausea and vomiting. However, it is very important that you continue to receive the medicine even if you begin to feel ill. Ask your doctor for ways to lessen these effects.
You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
This medicine is given through a needle placed in one of your veins. It is usually given every day for 5 days. This 5-day treatment is given again every 28 days until your body responds to the medicine. Each treatment usually takes about 30 minutes.
Precautions
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.
While you are being treated with fludarabine injection, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. Fludarabine injection may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid persons who have recently taken oral polio vaccine. Do not get close to them and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.
Fludarabine injection can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection (e.g. pneumonia). It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:
- If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you have fever or chills, cough or hoarseness, lower back or side pain, painful or difficult urination; shortness of breath; or unusual bleeding or bruising.
- Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in the urine or stools; or pinpoint red spots on your skin.
- Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.
- Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
- Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.
- Avoid contact sports or other situations where bruising or injury could occur.
You should not use this medicine if you are also taking pentostatin (Nipent®). Taking it together with this medicine may increase the chance of serious side effect.
This medicine may cause a serious type of reaction called tumor lysis syndrome. Your doctor may give you a medicine to help prevent this. Call your doctor right away if you have a decrease or change in urine amount; joint pain, stiffness, or swelling; lower back, side, or stomach pain; a rapid weight gain; swelling of the feet or lower legs; or unusual tiredness or weakness.
Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. You should not become pregnant while you are taking this medicine and for 6 months after stopping it. If you think you have become pregnant while using the medicine, tell your doctor right away.
This medicine may cause unusual weakness, trouble in thinking, or trouble in seeing clearly. Make sure you know how you react to this medicine before you drive, use machines, or do other jobs that require you to be alert, well-coordinated, or able to think or see well.
Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
- Arm, back, or jaw pain
- black, tarry stools
- blood in the urine or stools
- chest pain or discomfort
- chest tightness or heaviness
- constipation
- cough or hoarseness
- coughing or spitting up blood
- fast or irregular heartbeat
- fever or chills
- general feeling of discomfort or illness
- lower back or side pain
- nausea
- pain
- painful, burning, or difficult urination
- pale skin
- pinpoint red spots on the skin
- shortness of breath
- sneezing
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- stomach pain, severe
- sweating
- swelling
- tender, swollen glands in the neck
- thickening of bronchial secretions
- troubled breathing
- unusual bleeding or bruising
- unusual tiredness or weakness
- vomiting of blood or material that looks like coffee grounds
- wheezing
Less common
- Agitation
- aneurysm
- bleeding gums
- blurred vision
- confusion
- decreased urine output
- difficulty in breathing or swallowing
- dilated neck veins
- dizziness
- extreme fatigue
- fainting
- fast, pounding, or irregular heartbeat or pulse
- headache
- increased menstrual flow or vaginal bleeding
- irregular breathing
- loss of hearing
- nosebleeds
- numbness or tingling in the fingers, toes, or face
- pain, redness, or swelling in the arm or leg
- paralysis
- prolonged bleeding from cuts
- seizures
- slurred speech
- sudden and severe inability to speak
- temporary blindness
- weakness in the arm or leg on one side of the body, sudden and severe
- weight gain
Rare
- Blindness
- continuing vomiting
- dark-colored urine
- drowsiness
- frequent urination
- hives
- itching
- light-colored stools
- loss of appetite
- loss of consciousness
- lower abdominal cramping
- muscle tremors
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid, deep breathing
- restlessness
- skin rash
- stomach pain
- trouble speaking, thinking, or walking
- yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Abdominal pain
- bladder pain
- body aches or pain
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
- cloudy urine
- congestion
- diarrhea
- difficulty in moving
- dry mouth or throat
- flushed, dry skin
- frequent urge to urinate
- fruit-like breath odor
- increased hunger
- increased thirst
- increased urination
- joint pain
- muscle aching or cramping
- muscle pains or stiffness
- runny nose
- swollen joints
- trouble in swallowing
- voice changes
- weight loss
Less common
- Abdominal fullness
- bluish color of skin
- changes in skin color
- cracked lips
- dandruff
- decrease in height
- decreased urination
- difficulty in sleeping
- discouragement
- feeling sad or empty
- gaseous abdominal pain
- heartburn
- irritability
- loss of interest or pleasure
- lightheadedness
- oily skin
- pain or tenderness around the eyes and cheekbones
- rapid breathing
- recurrent fever
- stuffy nose
- sunken eye
- trouble concentrating
- wrinkled skin
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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