Chlorothiazide (intravenous route)

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies have not been performed on the relationship of age to the effects of chlorothiazide in the pediatric population. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of chlorothiazide in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment in the dose for patients receiving chlorothiazide.

Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Isocarboxazid

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acarbose
• Aceclofenac
• Acemetacin
• Acetyldigoxin
• Albiglutide
• Albuterol
• Alogliptin
• Amphetamine
• Amtolmetin Guacil
• Arsenic Trioxide
• Aspirin
• Benzhydrocodone
• Benzphetamine
• Bepridil
• Bromfenac
• Bromocriptine
• Bufexamac
• Buprenorphine
• Canagliflozin
• Cefepime
• Celecoxib
• Chlorpropamide
• Choline Salicylate
• Clonixin
• Codeine
• Dapagliflozin
• Deslanoside
• Desmopressin
• Dexibuprofen
• Dexketoprofen
• Dextroamphetamine
• Diazoxide
• Diclofenac
• Diflunisal
• Digitalis
• Digitoxin
• Digoxin
• Dihydrocodeine
• Dipyrone
• Dofetilide

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aminolevulinic Acid
• Calcium
• Ginkgo
• Gossypol
• Licorice

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Anuria (not able to form urine)—Should not be used in patients with this condition.

• Asthma or
• Diabetes or
• Gout or
• Hypercalcemia (high calcium in the blood) or
• Hyperuricemia (high uric acid in the blood) or
• Hypochloremia (low chloride in the blood) or
• Hypokalemia (low potassium in the blood) or
• Hypomagnesemia (low magnesium in the blood) or
• Hyponatremia (low sodium in the blood) or
• Hypophosphatemia (low phosphorus in the blood) or
• Liver disease or
• Systemic lupus erythematosus—Use with caution. This medicine may make these conditions worse.

• Kidney disease—Use with caution. The effects of the medicine may be increased because of slower removal of the medicine from the body.

Incidence not known

• Abdominal or stomach pain
• back, leg, or stomach pains
• black, tarry stools
• bleeding gums
• blisters on skin
• blood in urine or stools
• bloody or cloudy urine
• blue lips and fingernails
• blurred vision
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• chest pain
• chills
• clay-colored stools
• cold sweats
• confusion
• constipation
• cough or hoarseness
• coughing that sometimes produces a pink frothy sputum
• coughing up blood
• darkened urine
• decrease in urine output or decrease in urine-concentrating ability
• decreased frequency or amount of urine
• diarrhea
• difficult, fast, or noisy breathing, sometimes with wheezing
• difficulty swallowing
• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• dry mouth
• fast heartbeat
• feeling of constant movement of self or surroundings
• fever
• flushed, dry skin
• fruit-like breath odor
• general feeling of discomfort or illness
• general feeling of tiredness or weakness
• headache
• hives
• increased blood pressure
• increased hunger
• increased sensitivity of skin to sunlight
• increased sweating
• increased thirst
• increased urination
• indigestion
• itching
• joint pain, stiffness, or swelling
• loss of appetite
• lower back or side pain
• muscle cramps or pain
• nausea
• nosebleeds
• numbness, tingling, pain, or weakness in hands or feet
• pain in joints or muscles
• painful or difficult urination
• pains in stomach, side, or abdomen, possibly radiating to the back
• pale skin
• pinpoint red spots on skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• redness or other discoloration of skin
• redness, soreness, or itching skin
• seizures
• sensation of spinning
• severe sunburn
• shortness of breath
• skin rash
• sores, ulcers, or white spots on lips or in mouth
• sores, welting, or blisters
• sugar in the urine
• sweating
• swelling in legs and ankles
• swelling of face, fingers, or lower legs
• swollen or painful glands
• tenderness of salivary glands
• thickening of bronchial secretions
• tightness in chest
• trembling
• troubled breathing
• unexplained weight loss
• unpleasant breath odor
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusual weight loss
• vomiting of blood
• weight gain
• yellow eyes or skin

Incidence not known

• Blistering, peeling, or loosening of skin
• cracks in the skin
• cramping
• decreased interest in sexual intercourse
• difficulty having a bowel movement (stool)
• hair loss, thinning of hair
• inability to have or keep an erection
• loss in sexual ability, desire, drive, or performance
• loss of heat from the body
• muscle spasm
• pinpoint red or purple spots on skin
• red, irritated eyes
• red, swollen skin
• restlessness
• scaly skin
• weakness