Ceftriaxone (injection route)

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ceftriaxone in children. Because of ceftriaxone's toxicity, use in newborn and premature babies is not recommended.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ceftriaxone in the elderly.

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Calcium Acetate
• Calcium Chloride
• Calcium Gluceptate
• Calcium Gluconate
• Lactated Ringer's Solution
• Ringer's Solution

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Cholera Vaccine, Live
• Warfarin

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Anemia or
• Diarrhea or
• Gallbladder disease or
• Pancreatitis (inflammation of the pancreas) or
• Stomach or bowel disease (e.g., colitis), history of—Use with caution. May make these conditions worse.

• Hyperbilirubinemia (high bilirubin in the blood)—Should not be used in newborn (less than 28 days of age) and premature infants with this condition.

• Kidney disease or
• Liver disease—Use with caution. Effects may be increased because of slower removal of the medicine from the body.

• Liver disease, severe or
• Undernourished condition—May be worsened by ceftriaxone and you may need to take Vitamin K.

More common

• Black, tarry stools
• chest pain
• chills
• cough
• fever
• painful or difficult urination
• shortness of breath
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• swollen glands
• unusual bleeding or bruising
• unusual tiredness or weakness

Less common

• Diarrhea

Rare

• Abdominal or stomach cramps or tenderness
• back, leg, or stomach pains
• bleeding gums
• bloating
• blood in the urine or stools
• bloody nose
• bluish color
• changes in skin color
• clay-colored stools
• convulsions
• cough or hoarseness
• dark urine
• diarrhea, watery and severe, which may also be bloody
• difficulty with breathing
• difficulty with swallowing
• dizziness
• fast, irregular, pounding, or racing heartbeat or pulse
• feeling of discomfort
• feeling of warmth
• fever with or without chills
• general body swelling
• general feeling of tiredness or weakness
• headache
• hives
• increased sweating
• increased thirst
• inflammation of the joints
• itching
• loss of appetite
• lower back or side pain
• muscle aches
• nausea or vomiting
• noisy breathing
• nosebleeds
• pain
• pale skin
• pinpoint red spots on the skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• rash
• redness of the face, neck, arms, and occasionally, upper chest
• shortness of breath
• skin rash
• swelling of the foot or leg
• swollen lymph glands
• tenderness
• tightness in the chest
• troubled breathing with exertion
• unpleasant breath odor
• unusual weight loss
• vomiting of blood
• watery or bloody diarrhea
• wheezing
• yellowing of the eyes or skin

Incidence not known

• Blistering, peeling, or loosening of the skin
• chest pain
• coughing up blood
• decrease in the amount of urine
• excessive muscle tone
• increased menstrual flow or vaginal bleeding
• muscle stiffness, tension, or tightness
• nosebleeds
• paralysis
• prolonged bleeding from cuts
• red irritated eyes
• red or black, tarry stools
• red or dark brown urine
• red skin lesions, often with a purple center
• restlessness
• skin rash with a general disease
• swelling
• trouble sitting still
• unpleasant breath odor

Rare

• Acid or sour stomach
• belching
• bloated
• change in taste
• dizziness
• excess air or gas in the stomach or intestines
• full feeling
• headache
• heartburn
• indigestion
• itching of the vagina or genital area
• loss of taste
• pain during sexual intercourse
• passing gas
• stomach discomfort, upset, or pain
• thick, white vaginal discharge with no odor or with a mild odor

Incidence not known

• Hives or welts
• redness, swelling, or soreness of the tongue
• swelling or inflammation of the mouth