Argatroban (intravenous route)

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies have not been performed on the relationship of age to the effects of argatroban in the pediatric population. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of argatroban in the elderly. However, elderly patients are more likely to have age-related liver problems, which may require an adjustment of dosage in patients receiving argatroban.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Defibrotide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abciximab
• Aceclofenac
• Acemetacin
• Acenocoumarol
• Alipogene Tiparvovec
• Alteplase, Recombinant
• Amtolmetin Guacil
• Anagrelide
• Anistreplase
• Apixaban
• Aspirin
• Bemiparin
• Betrixaban
• Bivalirudin
• Bromfenac
• Bufexamac
• Cangrelor
• Caplacizumab-yhdp
• Celecoxib
• Choline Salicylate
• Cilostazol
• Citalopram
• Clonixin
• Clopidogrel
• Collagenase, Clostridium histolyticum
• Curcumin
• Dabigatran Etexilate
• Dalteparin
• Danaparoid
• Desvenlafaxine
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Diflunisal
• Dipyridamole
• Dipyrone
• Doxycycline
• Drotrecogin Alfa
• Droxicam
• Edoxaban

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Vitamin A

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Bleeding, active—Should not be used in patients with this condition.

• Blood disease or bleeding problems or
• High blood pressure, severe or
• Major surgery (e.g., eye, brain, or spine surgery) or
• Spinal anesthesia or lumbar puncture or
• Stomach or intestinal ulcer—Use with caution. The risk of bleeding may be increased.

• Liver disease—Effects may be increased because of slower removal of the medicine from the body.

More common

• Bleeding from the bladder
• blood in the urine
• blurred vision
• chest pain
• confusion
• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• fever
• no blood pressure or pulse
• stopping of heart
• sweating
• unconsciousness
• unusual tiredness or weakness

Less common

• Arm, back, or jaw pain
• bloody or black, tarry stools
• chest tightness or heaviness
• constipation
• cough or hoarseness
• coughing or spitting up blood
• fast, slow, or irregular heartbeat
• fast, pounding, or irregular heartbeat or pulse
• lower back or side pain
• nausea
• pain or discomfort in the arms, jaw, back, or neck
• painful or difficult urination
• palpitations
• severe stomach pain
• shortness of breath
• sweating
• vomiting
• vomiting of blood or material that looks like coffee grounds

Rare

• Abdominal pain or swelling
• back pain or backaches
• blue lips and fingernails
• changes in skin color
• cold hands and feet
• coughing that sometimes produces a pink frothy sputum
• diarrhea
• difficult, fast, noisy breathing, sometimes with wheezing
• increased sweating
• indigestion
• loss of appetite
• pain, redness, or swelling in the arm or leg
• pains in the chest, groin, or legs, especially calves of the legs
• pale skin
• passing of gas
• severe headaches of sudden onset
• stomach pain, fullness, or discomfort
• sudden loss of coordination
• sudden onset of shortness of breath for no apparent reason
• sudden onset of slurred speech
• sudden vision changes
• swelling in the legs and ankles