Undifferentiated pleomorphic sarcoma care at Mayo Clinic

Mayo Clinic medical oncologists, pathologists and many other specialists work together for undifferentiated pleomorphic sarcoma care.

A wide range of sarcoma specialists working as a coordinated team

At Mayo Clinic, medical oncologists, pathologists, surgical oncologists, radiation oncologists, musculoskeletal radiologists, interventional radiologists and plastic surgeons work as a multidisciplinary team to care for people with undifferentiated pleomorphic sarcoma. Other departmental specialists collaborate as needed: gynecologic oncologists, ear, nose and throat (ENT) specialists (otorhinolaryngologists), urologic oncologists, and others. Other professionals, such as rehabilitation specialists, are included as needed.

Comprehensive, specialized expertise

Undifferentiated pleomorphic sarcoma is rare, and it can be difficult to diagnose and treat. Mayo Clinic doctors care for more than 2,000 people with soft tissue sarcomas each year, including very rare types. This means your care team is prepared with the knowledge and resources to provide you with exactly the care you need.

A Mayo Clinic doctor explains and discusses undifferentiated pleomorphic sarcoma treatment options.

Full range of treatment options

Mayo Clinic doctors will work with you to review all of your treatment options and choose the treatment that best suits your needs and goals. The range of possible treatments for people with undifferentiated pleomorphic sarcoma includes several types of surgery — including minimally invasive surgery and limb-sparing surgery — as well as the latest radiation therapy techniques, including intensity-modulated radiation therapy, proton beam therapy, brachytherapy and intraoperative radiation therapy (IORT). A full range of systemic therapies, including chemotherapy and biological therapy also are available.

Expertise and rankings

A doctor converses with a woman about undifferentiated pleomorphic sarcoma

Mayo Clinic doctors have the knowledge and resources to provide comprehensive care for people with rare cancers, including undifferentiated pleomorphic sarcoma. At Mayo Clinic, you can expect:

  • Personalized care. At Mayo Clinic, medical oncologists, pathologists, surgical oncologists, radiation oncologists, musculoskeletal radiologists, interventional radiologists and plastic surgeons work as a team to make sure all of your individual needs are addressed in your care plan. Other experts are included as needed.
  • Experience you can trust. Mayo Clinic doctors have extensive experience caring for people with soft tissue sarcoma, including rare types. Each year, Mayo Clinic doctors care for more than 2,000 people with soft tissue sarcoma.
  • Nationally recognized expertise. Mayo Clinic Comprehensive Cancer Center meets the strict standards for a National Cancer Institute comprehensive cancer center, which recognize scientific excellence and a multispecialty approach focused on cancer prevention, diagnosis and treatment.

Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Jacksonville, Florida, and Mayo Clinic in Phoenix/Scottsdale, Arizona, are ranked among the Best Hospitals for cancer by U.S. News & World Report.

Locations, travel and lodging

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

For more information on visiting Mayo Clinic, choose your location below:

Costs and insurance

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.

In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Learn more about appointments at Mayo Clinic.

Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.

Get Mayo Clinic cancer expertise delivered to your inbox.

Subscribe for free and receive an in-depth guide to coping with cancer, plus helpful information on how to get a second opinion. You can unsubscribe at any time. Click here for an email preview.

I would like to learn more about

To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. If you are a Mayo Clinic patient, this could include protected health information. If we combine this information with your protected health information, we will treat all of that information as protected health information and will only use or disclose that information as set forth in our notice of privacy practices. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail.

More information about billing and insurance:

Mayo Clinic in Arizona, Florida and Minnesota

Mayo Clinic Health System

Dec. 30, 2023

Living with undifferentiated pleomorphic sarcoma?

Connect with others like you for support and answers to your questions in the Sarcoma support group on Mayo Clinic Connect, a patient community.

Sarcoma Discussions

Colleen Young, Connect Director
Diagnosed with sarcoma? Let's share

812 Replies Tue, Jul 09, 2024

Undifferentiated Pleomorphic Sarcoma

59 Replies Fri, Jun 21, 2024

See more discussions