Undifferentiated pleomorphic sarcoma care at Mayo Clinic
A wide range of sarcoma specialists working as a coordinated team
At Mayo Clinic, medical oncologists, pathologists, surgical oncologists, radiation oncologists, musculoskeletal radiologists, interventional radiologists and plastic surgeons work as a multidisciplinary team to care for people with undifferentiated pleomorphic sarcoma. Other departmental specialists collaborate as needed: gynecologic oncologists, ear, nose and throat (ENT) specialists (otolaryngologists), urologic oncologists and others. Rehabilitation specialists and other professionals are included as needed.
Full range of treatment options
Intraoperative radiation therapy for sarcoma
Intraoperative radiation therapy for sarcoma
During intraoperative radiation therapy (IORT), radiation is directed through the surgical incision onto a specific site. The dose of IORT can be much higher than is possible with standard radiation therapy.
Mayo Clinic doctors work with you to review all your treatment options and choose the treatment that best suits your needs and goals. The range of possible treatments for people with undifferentiated pleomorphic sarcoma includes several types of surgery, such as minimally invasive surgery and limb-sparing surgery. Treatment also may include radiation therapy. Mayo Clinic offers the latest radiation therapy techniques, including intensity-modulated radiation therapy (IMRT), proton beam therapy, brachytherapy and intraoperative radiation therapy (IORT). A full range of systemic therapies, including chemotherapy and biological therapy, also are available.
Expertise and rankings
Mayo Clinic doctors have the knowledge and resources to provide comprehensive care for people with rare cancers, including undifferentiated pleomorphic sarcoma. At Mayo Clinic, you can expect:
- Personalized care. At Mayo Clinic, medical oncologists, pathologists, surgical oncologists, radiation oncologists, musculoskeletal radiologists, interventional radiologists and plastic surgeons work as a team to make sure all your individual needs are addressed in your care plan. Other experts are included as needed.
- Experience you can trust. Mayo Clinic doctors are respected for their experience in caring for people with all types of soft tissue sarcoma, including very rare types such as undifferentiated pleomorphic sarcoma. Each year, Mayo Clinic doctors care for more than 2,400 people with soft tissue sarcoma.
- Nationally recognized expertise. Mayo Clinic Comprehensive Cancer Center meets the strict standards for a National Cancer Institute comprehensive cancer center. These standards recognize scientific excellence and a multispecialty approach focused on cancer prevention, diagnosis and treatment.
Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Jacksonville, Florida, and Mayo Clinic in Phoenix/Scottsdale, Arizona, are ranked among the Best Hospitals for cancer by U.S. News & World Report.
Locations, travel and lodging
Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.
For more information on visiting Mayo Clinic, choose your location below:
Costs and insurance
Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.
In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.
Learn more about appointments at Mayo Clinic.
Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.
Aug. 12, 2026