Survival rates By Mayo Clinic Staff The chance of surviving primary mediastinal large B-cell lymphoma (PMBCL) is different for every person. Factors include your overall health, the stage of your cancer, treatments you are receiving and how you respond to treatment. PMBCL carries the risk of the cancer coming back after treatment, known as a relapse. Most relapses happen within the first two years after treatment. The overall five-year survival rate for primary mediastinal large B-cell lymphoma typically exceeds 80%. This means that more than 80% of patients with a diagnosis of PMBCL are alive after five years from diagnosis. PrognosisThe cancer prognosis tells how likely it is that the cancer can be treated successfully. Your healthcare team can get a general sense of your outlook using your primary mediastinal large B-cell lymphoma (PMBCL) stage and your overall health. Talk with your healthcare team about your prognosis if you want to know what to expect. Members of your healthcare team can explain what they consider when thinking about your prognosis. Request an appointment StagesDoctors & departments March 07, 2026 Share on: FacebookTwitter Living with primary mediastinal large B-cell lymphoma? Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. Blood Cancers & Disorders Discussions Primary Myelofibrosis diagnosis in 40’s 14 Replies Sun, May 24, 2026 chevron-right Anyone have chronic lymphocytic leukemia (CLL)? 323 Replies Sun, May 24, 2026 chevron-right Essential thrombocythemia (ET): When to start hydroxyurea (HU)? 116 Replies Sun, May 24, 2026 chevron-right See more discussions Show references B-cell lymphomas. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1480. Accessed Dec. 17, 2025. Aster JC, et al. Primary mediastinal large B-cell lymphoma. https://www.uptodate.com/contents/search. Accessed Dec. 17, 2025. Brown JR, et al. Pathobiology of diffuse large B-cell lymphoma and primary mediastinal large B-cell lymphoma. https://www.uptodate.com/contents/search. Accessed Dec. 17, 2025. Hsi ED, et al., eds. Diffuse aggressive B-cell lymphomas. In: Hematopathology: Foundations in Diagnostic Pathology. 4th ed. Elsevier; 2026. https://www.clinicalkey.com. Accessed Dec. 17, 2025. Mediastinum. Dorland's Medical Dictionary Online. https://www.dorlandsonline.com. Accessed Dec. 17, 2025. Paulson CL. Allscripts EPSi. Mayo Clinic. July 15, 2025. Related Associated Procedures Biological therapy for cancer Bone marrow transplant CAR-T cell therapy Chemotherapy CT scan Positron emission tomography (PET) scan Radiation therapy Show more associated procedures Primary mediastinal large B-cell lymphomaSymptoms&causesDiagnosis&treatmentStagesSurvivalratesDoctors&departmentsCare atMayoClinic CON-20592493 Diseases & Conditions Primary mediastinal large B-cell lymphoma